Cited by 4,742Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsCardiovascular Function and Risk Factors

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Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

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Celermajer, D.S., Sorensen, K.E., Gooch, V.M., Spiegelhalter, D.J., Miller, O.I., Sullivan, I.D., Lloyd, J.K., Deanfield, J.E.·1992·The Lancet

DOI 10.1016/0140-6736(92)93147-f

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Abstract

Endothelial dysfunction is an early event in experimental studies of atherogenesis, preceding formation of plaques. We have devised a non-invasive method for testing endothelial function, to find out whether abnormalities are present in symptom-free children and young adults at high risk of atherosclerosis. With high-resolution ultrasound, we measured the diameter of the superficial femoral and brachial arteries at rest, during reactive hyperaemia (with increased flow causing endothelium-dependent dilatation), and after sublingual glyceryl trinitrate (GTN; causing endothelium-independent dilatation) in 100 subjects--50 controls without vascular risk factors (aged 8-57 years), 20 cigarette smokers (aged 17-62 years), 10 children with familial hypercholesterolaemia (FH; aged 8-16 years), and 20 patients with established coronary artery disease (CAD). Adequate scans were obtained in all but 6 cases. Flow-mediated dilatation was observed in arteries from all control subjects. Dilatation was inversely related to baseline vessel diameter (r = -0.81, p < 0.0001); in arteries of 6.0 mm or less, mean dilatation was 10 (SE 2)%. In smokers, FH children, and adults with CAD, flow-mediated dilatation was much reduced or absent (p < 0.001 for comparison with each relevant control group). Dilatation in response to GTN was present in all groups. Endothelial dysfunction is present in children and adults with risk factors for atherosclerosis, such as smoking and hypercholesterolaemia, before anatomical evidence of plaque formation in the arteries studied. This may be an important early event in atherogenesis.

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The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
The Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,885
Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422
Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
Brown, G., Albers, J. J., Fisher, L. D., Schaefer, S. M., Lin, J.-T., Kaplan, C., Zhao, X.-Q., Bisson, B. D., Fitzpatrick, V. F., & Dodge, H. T. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011083231901 · Cited by 2,159
Flow-induced release of endothelium-derived relaxing factor
Rubanyi, G. M., Romero, J. C., & Vanhoutte, P. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.6.h1145 · Cited by 1,373
Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
Vita, J. A., Treasure, C. B., Nabel, E. G., McLenachan, J. M., Fish, R. D., Yeung, A. C., Vekshtein, V. I., Selwyn, A. P., & Ganz, P. (1990) · Circulation · doi:10.1161/01.cir.81.2.491 · Cited by 1,172
Cholesterol and Mortality
Anderson, K. M. (1987) · JAMA · doi:10.1001/jama.257.16.2176 · Cited by 1,071
Crucial role of endothelium in the vasodilator response to increased flow in vivo.
Pohl, U., Holtz, J., Busse, R., & Bassenge, E. (1986) · Hypertension · doi:10.1161/01.hyp.8.1.37 · Cited by 984
CORONARY DISEASE AMONG UNITED STATES SOLDIERS KILLED IN ACTION IN KOREA
Enos, W. F. (1953) · JAMA · doi:10.1001/jama.1953.03690120006002 · Cited by 891

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Orth, S. R., Ritz, E., & Schrier, R. W. (1997) · Kidney International · doi:10.1038/ki.1997.232 · Cited by 210
Central Role of eNOS in the Maintenance of Endothelial Homeostasis
Heiß, C., Rodriguez‐Mateos, A., & Kelm, M. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6158 · Cited by 212
Endothelial dysfunction in insulin resistance and type 2 diabetes
Jansson, P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01830.x · Cited by 203
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Kapiotis, S., Holzer, G., Schaller, G., Haumer, M., Widhalm, H., Weghuber, D., Jilma, B., Röggla, G., Wolzt, M., Widhalm, K., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000245795.08139.70 · Cited by 205
Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: Pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging
Schroeder, S., Enderle, M. D., Ossen, R., Meisner, C., Baumbach, A., Pfohl, M., Herdeg, C., Oberhoff, M., Haering, H. U., & Karsch, K. R. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70189-4 · Cited by 204
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Desouza, C. V., Parulkar, A., Lumpkin, D., Akers, D. L., & Fonseca, V. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1336 · Cited by 204
Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis
Balci, D., Balcı, A., Karazincir, S., Ucar, E., İyigün, U., Yalçın, F., Seyfeli, E., İnandı, T., & Eğilmez, E. (2008) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.02936.x · Cited by 203
Risk Factors and Segment-Specific Carotid Arterial Enlargement in the Atherosclerosis Risk in Communities (ARIC) Cohort
Crouse, J. R., Goldbourt, U., Evans, G., Pinsky, J. L., Sharrett, A. R., Sorlie, P. D., Riley, W. A., & HEISS, G. M. (1996) · Stroke · doi:10.1161/01.str.27.1.69 · Cited by 203
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Williams, M. J. A., Sutherland, W. H. F., McCormick, M. P., de Jong, S. A., Walker, R. J., & WILKINS, G. T. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00681-0 · Cited by 202
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Atkinson, G., Batterham, A. M., Thijssen, D. H. J., & GREEN, D. J. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835b8164 · Cited by 200
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Nishizaka, M., Zaman, M. A., Green, S. A., Renfroe, K. Y., & Calhoun, D. A. (2004) · Circulation · doi:10.1161/01.cir.0000129307.26791.8e · Cited by 201
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de Divitiis, M., Pilla, C. B., Kattenhorn, M., Donald, A. E., Zadinello, M., Wallace, S. M. L., Redington, A. N., & Deanfield, J. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00480-7 · Cited by 200
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Sympathetic Control of the Cerebral Vasculature in Humans
Hamner, J. W., Tan, C. O., Lee, K., Cohen, M. A., & Taylor, J. A. (2009) · Stroke · doi:10.1161/strokeaha.109.557132 · Cited by 198
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Fathi, R. B., Haluska, B. A., Isbel, N. M., Short, L., & Marwick, T. H. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.09.042 · Cited by 198
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Oxidized Low-Density Lipoprotein and Atherosclerosis Implications in Antioxidant Therapy
Mitra, S., Deshmukh, A. J., Sachdeva, R., Lü, J., & Mehta, J. L. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318224a147 · Cited by 197
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Lazdam, M., de la Horra, A., Pitcher, A., Mannie, Z. N., Diesch, J., Trevitt, C., Kylintireas, I., Contractor, H., Singhal, A., Lucas, A., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.150235 · Cited by 193
Effects of exercise on vascular function, structure, and health in humans
Green, D. J., & Smith, K. J. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029819 · Cited by 197
Brugada syndrome: 1992–2002
Antzelevitch, C. N., Brugada, P., Brugada, J., Brugada, R., Towbin, J. A., & Nademanee, K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00310-3 · Cited by 193
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Gavin, K. M., Seals, D. R., Silver, A., & Moreau, K. L. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0278 · Cited by 202
Explorations in statistics: the analysis of ratios and normalized data
Curran‐Everett, D. (2013) · AJP Advances in Physiology Education · doi:10.1152/advan.00053.2013 · Cited by 193
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Gaeta, G. B., Michele, M. D., Cuomo, S., Guarini, P., Foglia, M. C., Bond, M. G., & Trevisan, M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431203 · Cited by 195
Induction and Decay of Short-Term Heat Acclimation in Moderately and Highly Trained Athletes
Garrett, A. T., Rehrer, N. J., & Patterson, M. J. (2011) · Sports Medicine · doi:10.2165/11587320-000000000-00000 · Cited by 209
Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men
Franzoni, F., Ghiadoni, L., Galetta, F., PLANTINGA, Y., Lubrano, V., Huang, Y., Salvetti, G., Regoli, F., Taddei, S., & Santoro, G. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.006 · Cited by 192
Endothelial Dysfunction: From Molecular Mechanisms to Measurement, Clinical Implications, and Therapeutic Opportunities
Brocq, M. L. L., Leslie, S. J., Milliken, P. H., & Megson, I. L. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.2013 · Cited by 196
Is the Association Between Flow-Mediated Dilation and Cardiovascular Risk Limited to Low-Risk Populations?
Witte, D. R., Westerink, J., de Koning, E. J. P., van der Graaf, Y., Grobbee, D. E., & Bots, M. L. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.073 · Cited by 191
Endothelial dysfunction in MELAS improved by l-arginine supplementation
Koga, Y., Akita, Y., Junko, N., Yatsuga, S., Povalko, N., Fukiyama, R., Ishii, M., & Matsuishi, T. (2006) · Neurology · doi:10.1212/01.wnl.0000220197.36849.1e · Cited by 190
Vascular adaptation in athletes: is there an ‘athlete's artery’?
GREEN, D. J., Spence, A. L., Rowley, N., Thijssen, D. H. J., & Naylor, L. H. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.058826 · Cited by 189
Predictors of Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome
Kravariti, M., Naka, K. Κ., Kalantaridou, S., Kazakos, N., Katsouras, C. S., Makrigiannakis, A., Paraskevaidis, E. A., Chrousos, G. P., Tsatsoulis, A. A., & Michalis, L. K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0151 · Cited by 188

Authors: Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E.
Affiliations: Great Ormond Street Hospital (GB)
ORCID: Celermajer, D.S.
Spiegelhalter, D.J.
Miller, O.I.
Deanfield, J.E.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1992-11
Volume: 340
Issue: 8828
Pages: 1111-1115
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/0140-6736(92)93147-f
OpenAlex: W2063506869
Cited by: 4,742
References: 32
Citations by year: 2026: 40 · 2025: 74 · 2024: 77 · 2023: 105 · 2022: 96 · 2021: 118 · 2020: 133 · 2019: 117 · 2018: 145 · 2017: 144 · 2016: 183 · 2015: 158 · 2014: 198 · 2013: 210 · 2012: 224
FWCI: 23.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Hjerteforeningen
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: endothelial dysfunction, atherosclerosis, flow-mediated dilation, reactive hyperemia, nitroglycerin, superficial femoral artery, brachial artery, high-resolution ultrasound, familial hypercholesterolemia, smoking, coronary artery disease, children, atherogenesis, vascular risk factors
MeSH terms: Adolescent, Adult, Aged, Arteriosclerosis, Blood Flow Velocity, Brachial Artery, Child, Coronary Disease, Endothelium, Vascular, Female, Femoral Artery, Humans, Hyperlipoproteinemia Type II, Male, Middle Aged, Risk Factors, Smoking, Ultrasonography, Reproducibility of Results

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Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

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