The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Intestinal permeability and the prediction of relapse in Crohn's disease
Abstract
To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p < 0.001). The sensitivity of the permeability test as a predictor for relapse was 81%. A significant correlation was found between the value of the permeability index and the probability of relapse (p < 0.01). These results show that increases in intestinal permeability precede clinical relapses in Crohn's disease and so are an indicator of subclinical disease. The measurement of intestinal permeability may lead to a better understanding of the pathogenesis of Crohn's disease.
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“Other objective measures associated with disease activity for IBD such as fecal calprotectin 31 , gut permeability 32 or gut lavage fluid protein have high sensitivity for presence or absence of active disease 33 .”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [32]
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Evaluation of survival data and two new rank order statistics arising in its consideration.
Mantel, N. (1966) · PubMed · Cited by 7,516
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147
Plackett, R. L., & Cox, D. R. (1971) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2344247 · Cited by 2,274
European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment
Malchow, H. A., Ewe, K., Brandes, J. W., Goebell, H., Ehms, H., Sommer, H., & Jesdinsky, H. J. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90409-8 · Cited by 931
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
Groß, V., Andus, T., Caesar, I., Roth, M., & Schölmerich, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90098-j · Cited by 293
A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease
Brignola, C., Campieri, M., Bazzocchi, G., Farruggia, P., Tragnone, A., & Lanfranchi, G. A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90206-4 · Cited by 159
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Metadata
- Authors
- Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H.
- Corresponding author
- Lochs, H.
- ORCID
- Waldhoer, T.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 341
- Issue
- 8858
- Pages
- 1437-1439
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2080195364
- Cited by
- 626
- References
- 16
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 12 · 2023: 15 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 22 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 17 · 2012: 26
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- Crohn's disease, intestinal permeability, recurrence prediction, lactulose/mannitol test, permeability index, subclinical disease, pathogenesis, inflammatory bowel disease
- MeSH terms
- Adult, Crohn Disease, Female, Humans, Intestinal Mucosa, Lactulose, Male, Mannitol, Permeability, Predictive Value of Tests, Recurrence
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