Cited by 626Inflammatory Bowel DiseaseGastrointestinal motility and disordersOcular Diseases and Behçet’s Syndrome

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Intestinal permeability and the prediction of relapse in Crohn's disease

Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., Lochs, H.·1993·The Lancet

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Abstract

To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p < 0.001). The sensitivity of the permeability test as a predictor for relapse was 81%. A significant correlation was found between the value of the permeability index and the probability of relapse (p < 0.01). These results show that increases in intestinal permeability precede clinical relapses in Crohn's disease and so are an indicator of subclinical disease. The measurement of intestinal permeability may lead to a better understanding of the pathogenesis of Crohn's disease.

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Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Applied logistic regression
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Evaluation of survival data and two new rank order statistics arising in its consideration.
Mantel, N. (1966) · PubMed · Cited by 7,516
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147
The Analysis of Binary Data.
Plackett, R. L., & Cox, D. R. (1971) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2344247 · Cited by 2,274
European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment
Malchow, H. A., Ewe, K., Brandes, J. W., Goebell, H., Ehms, H., Sommer, H., & Jesdinsky, H. J. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90409-8 · Cited by 931
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
Groß, V., Andus, T., Caesar, I., Roth, M., & Schölmerich, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90098-j · Cited by 293
A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease
Brignola, C., Campieri, M., Bazzocchi, G., Farruggia, P., Tragnone, A., & Lanfranchi, G. A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90206-4 · Cited by 159

Show all 16 references

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Panés, J. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00905.x · Cited by 26
Catholic Bridging Efforts with China
Leung, B. K. F. (2000) · Religion State & Society · doi:10.1080/08923970600815048 · Cited by 25
Gas chromatography applied to the lactulose—mannitol intestinal permeability test
Dumas, F., Aussel, C., Pernet, P., Martin, C., & GIBOUDEAU, J. (1994) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(94)00041-7 · Cited by 25
Significance of increased human colonic permeability in response to corticotrophin-releasing hormone (CRH)
Ferrier, L. (2007) · Gut · doi:10.1136/gut.2007.129841 · Cited by 25
Lactulose/Mannitol Test Has High Efficacy for Excluding Organic Causes of Chronic Diarrhea
Leo, V. D., Renata D'Incà, Diaz-Granado, N., Fries, W., Venturi, C., D’Odorico, A., Martines, D., & Sturniolo, G. C. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07697.x · Cited by 25
Assessing intestinal permeability in Crohn’s disease patients using orally administered 52Cr-EDTA
von Martels, J. Z. H., Bourgonje, A. R., Harmsen, H. J. M., Faber, K. N., & Dijkstra, G. D. H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211973 · Cited by 24
Functional Food Components, Intestinal Permeability and Inflammatory Markers in Patients with Inflammatory Bowel Disease
Lacerda, J. D. H. L. F., Lagos, A. C., Carolino, E., Silva-Herdade, A. S., Silva, M., & Guerreiro, C. S. (2021) · Nutrients · doi:10.3390/nu13020642 · Cited by 27
Adaptation of Intestinal Nutrient Transport in Health and Disease (Part II)
Thomson, A. B. R., & Wild, G. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018874404762 · Cited by 24
Assessment of Intestinal Permeability with a Two-Hour Urine Collection
Akram, S., Mourani, S., Ou, C., Rognerud, C. L., Sadiq, R., & Goodgame, R. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018826307489 · Cited by 24
Towards an understanding of the role of NOD2/CARD15 in the pathogenesis of Crohn's disease
Philpott, D. J., & Viala, J. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2003.12.004 · Cited by 24
Bacteria-Derived Compatible Solutes Ectoine and 5α-Hydroxyectoine Act as Intestinal Barrier Stabilizers to Ameliorate Experimental Inflammatory Bowel Disease
Abdel-Aziz, H., Wadie, W., Scherner, O., Efferth, T., & Khayyal, M. T. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00115 · Cited by 23
Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn’s Disease
Guo, C., & Shen, J. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08795-5 · Cited by 23
S3-Leitlinie der Deutschen Gesellschaft fur Ernährungsmedizin (DGEM) in Zusammenarbeit mit der Gesellschaft für klinische Ernährung der Schweiz (GESKES), der Österreichischen Arbeitsgemeinschaft fur klinische Ernährung (AKE) und der Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)
Bischoff, S., Koletzko, B. V., Lochs, H. H., Meier, R., & Arends, J. (2014) · Aktuelle Ernährungsmedizin · doi:10.1055/s-0034-1370084 · Cited by 23
Self-citation
Is an Increased Intestinal Permeability a Valid Predictor of Relapse in Crohn Disease?
Jørgensen, P. J. R. J., Ranløv, P. J., Bjerrum, P. J., Diemer, H., Bisgaard, K., & Elsborg, L. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520118812 · Cited by 23
Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease
Schulte, L.-A., Hohwieler, M., Müller, M., & Klaus, J. (2019) · Stem Cells International · doi:10.1155/2019/8010645 · Cited by 22
The association of zonulin-related proteins with prevalent and incident inflammatory bowel disease
Wang, X., Memon, A. A., Palmér, K., Hedelius, A., Sundquist, J., & Sundquist, K. (2022) · BMC Gastroenterology · doi:10.1186/s12876-021-02075-y · Cited by 22
Tight junction regulation, intestinal permeability, and mucosal immunity in gastrointestinal health and disease
Saha, K., Zhou, Y., & Turner, J. R. (2024) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000001066 · Cited by 21
Food as Treatment of Inflammatory Bowel Diseases
Maldonado‐Contreras, A. (2022) · Infection and Immunity · doi:10.1128/iai.00583-21 · Cited by 24
The Correlation between Endotoxin, D-Lactate, and Diamine Oxidase with Endoscopic Activity in Inflammatory Bowel Disease
Zhang, Q., Gao, X., Jixiong, W., & Chen, M. (2022) · Disease Markers · doi:10.1155/2022/9171436 · Cited by 21
Adrenomedullin improves intestinal epithelial barrier function by downregulating myosin light chain phosphorylation in ulcerative colitis rats
Yi, Z.-F., Fan, H., Liu, X., TANG, Q., ZUO, D., & Yang, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3887 · Cited by 21
Alterations in intestinal permeability following the intensified polydrug-chemotherapy IFADIC (ifosfamide, Adriamycin, dacarbazine)
Fazeny-Dörner, B., Veitl, M., Wenzel, C., Brodowicz, T., Zielinski, C. C., Muhm, M., Vogelsang, H., & Marosi, C. (2002) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-001-0414-2 · Cited by 21
Self-citation
Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats
Schepens, M. A. A., Rijnierse, A., Schonewille, A. J., Vink, C., Brummer, R. J., Willemsen, L. E. M., van der Meer, R., & Bovee-Oudenhoven, I. M. J. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002990 · Cited by 21
In Vitro Production of Endomysial Antibodies in Cultured Duodenal Mucosa From Patients With Celiac Disease
Vogelsang, H., Schwarzenhofer, M., Granditsch, G., & Oberhuber, G. (1999) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00069-6 · Cited by 21
Self-citation
Barrier Dysfunction and Crohn's Disease
Meddings, J. B. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05261.x · Cited by 21
Follow-up of adult celiac patients: which noninvasive test reflects mucosal status most reliably?
Vécsei, A., Graf, U., & Vogelsang, H. (2009) · Endoscopy · doi:10.1055/s-0028-1103484 · Cited by 21
Self-citation
Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for ‘leaky-gut’ in inflammatory bowel disease
Wasinger, V. C., Lu, K., Yau, Y. Y., Nash, J., Lee, J., Chang, J., Paramsothy, S., Kaakoush, N. O., Mitchell, H. M., & Leong, R. W. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-69746-w · Cited by 20

Authors: Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H.
Corresponding author: Lochs, H.
ORCID: Waldhoer, T.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1993-06
Volume: 341
Issue: 8858
Pages: 1437-1439
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/0140-6736(93)90882-h
OpenAlex: W2080195364
Cited by: 626
References: 16
Citations by year: 2026: 6 · 2025: 19 · 2024: 12 · 2023: 15 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 22 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 17 · 2012: 26
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: Crohn's disease, intestinal permeability, recurrence prediction, lactulose/mannitol test, permeability index, subclinical disease, pathogenesis, inflammatory bowel disease
MeSH terms: Adult, Crohn Disease, Female, Humans, Intestinal Mucosa, Lactulose, Male, Mannitol, Permeability, Predictive Value of Tests, Recurrence

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Intestinal permeability and the prediction of relapse in Crohn's disease

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