Cited by 626Inflammatory Bowel DiseaseGastrointestinal motility and disordersOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Intestinal permeability and the prediction of relapse in Crohn's disease

Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., Lochs, H.·1993·The Lancet

Open this paper in CoChat — free account

Abstract

To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p < 0.001). The sensitivity of the permeability test as a predictor for relapse was 81%. A significant correlation was found between the value of the permeability index and the probability of relapse (p < 0.01). These results show that increases in intestinal permeability precede clinical relapses in Crohn's disease and so are an indicator of subclinical disease. The measurement of intestinal permeability may lead to a better understanding of the pathogenesis of Crohn's disease.

Integrity signals

Registry

Crossref · 10.1016/0140-6736(93)90882-h

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Applied logistic regression
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Evaluation of survival data and two new rank order statistics arising in its consideration.
Mantel, N. (1966) · PubMed · Cited by 7,516
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147
The Analysis of Binary Data.
Plackett, R. L., & Cox, D. R. (1971) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2344247 · Cited by 2,274
European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment
Malchow, H. A., Ewe, K., Brandes, J. W., Goebell, H., Ehms, H., Sommer, H., & Jesdinsky, H. J. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90409-8 · Cited by 931
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
Groß, V., Andus, T., Caesar, I., Roth, M., & Schölmerich, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90098-j · Cited by 293
A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease
Brignola, C., Campieri, M., Bazzocchi, G., Farruggia, P., Tragnone, A., & Lanfranchi, G. A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90206-4 · Cited by 159

Show all 16 references

Sorted by citations

Items 101–200 of 619

Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn's disease: Results from a randomised double‐blind placebo‐controlled study
Raftery, T. C., Martineau, A. R., Greiller, C. L., Ghosh, S. K., McNamara, D. A., Bennett, K., Meddings, J. B., & OʼSullivan, M. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615572176 · Cited by 181
Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner
Šrůtková, D., Schwarzer, M., Hudcovic, T., Zakostelska, Z. J., Dráb, V., Španová, A., Rittich, B., Kozáková, H., & Schabussová, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134050 · Cited by 172
The primary defect in experimental ileitis originates from a nonhematopoietic source
Olson, T. S., Reuter, B. K., Scott, K. G. –., MORRIS, M. A., Wang, X.-M., Hancock, L. N., Burcin, T. L., Cohn, S. M., Ernst, P. B., Cominelli, F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050407 · Cited by 172
Amelioration of IFN-γ and TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Berberine via Suppression of MLCK-MLC Phosphorylation Signaling Pathway
Cao, M., Wang, P., Sun, C., He, W., & Wang, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061944 · Cited by 168
Modulation of Intestinal Epithelial Permeability by Plasma from Patients with Crohn’s Disease in a Three-dimensional Cell Culture Model
Xu, P., Elamin, E. E., Elizalde, M., Bours, P. H. A., Pierik, M. J., Masclee, A., & Jonkers, D. M. A. E. (2019) · Scientific Reports · doi:10.1038/s41598-018-38322-8 · Cited by 168
Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction
Demaude, J. (2006) · Gut · doi:10.1136/gut.2005.078675 · Cited by 167
Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection
Burge, K. Y., Gunasekaran, A., Eckert, J. V., & Chaaban, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081912 · Cited by 173
Non-invasive investigation of inflammatory bowel disease
Tibble, J. A. (2001) · World Journal of Gastroenterology · doi:10.3748/wjg.v7.i4.460 · Cited by 167
Genetics of ulcerative colitis
Thompson, A., & Lees, C. W. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21375 · Cited by 171
Vitamin D, vitamin D receptor and tissue barriers
Zhang, Y., Wu, S., & Sun, J. (2013) · Tissue Barriers · doi:10.4161/tisb.23118 · Cited by 164
IBD Candidate Genes and Intestinal Barrier Regulation
McCole, D. F. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000090 · Cited by 162
Molecular Ecological Analysis of the Succession and Diversity of Sulfate-Reducing Bacteria in the Mouse Gastrointestinal Tract
Deplancke, B., Hristova, K. R., Oakley, H. A., McCracken, V. J., Aminov, R. I., Mackie, R. I., & Gaskins, H. R. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.5.2166-2174.2000 · Cited by 159
Enteric glial cells and their role in the intestinal epithelial barrier
Yu, Y. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11273 · Cited by 158
Resistin-like molecule β regulates innate colonic function: Barrier integrity and inflammation susceptibility
Hogan, S. P., Seidu, L., Blanchard, C., Groschwitz, K. R., Mishra, A., Karow, M. L., Ahrens, R., Artis, D., Murphy, A. J., Valenzuela, D. M., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.039 · Cited by 158
Modulation of colonic barrier function by the composition of the commensal flora in the rat
Garcia-Lafuente, A. M., Antolı́n, M., Guarner, F., Crespo, E., & Malagelada, J. R. (2001) · Gut · doi:10.1136/gut.48.4.503 · Cited by 156
Polymorphisms in E-cadherin ( CDH1 ) result in a mis-localised cytoplasmic protein that is associated with Crohn’s disease
Muise, A. M., Walters, T. D., Glowacka, W. K., Griffiths, A. M., Ngan, B., Lan, H., Xu, W., Silverberg, M. S., & Rotin, D. (2009) · Gut · doi:10.1136/gut.2008.175117 · Cited by 165
The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease
Vanuytsel, T., Vermeire, S., & Cleynen, I. (2013) · Tissue Barriers · doi:10.4161/tisb.27321 · Cited by 152
Clinical relevance of serum interleukin-6 in Crohn’s disease: single point measurements, therapy monitoring, and prediction of clinical relapse
Reinisch, W., Gasché, C., Tillinger, W., Wyatt, J., Lichtenberger, C., Willheim, M., Dejaco, C., Waldhör, T., Bakos, S., Vogelsang, H., et al. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01288.x · Cited by 150
Self-citation
Mechanisms and Functional Implications of Intestinal Barrier Defects
Shen, L., Su, L., & Turner, J. R. (2009) · Digestive Diseases · doi:10.1159/000233282 · Cited by 149
Zinc and gastrointestinal disease
Skrovanek, S. M. (2014) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v5.i4.496 · Cited by 148
Use of the Lactulose to Mannitol Ratio to Evaluate Childhood Environmental Enteric Dysfunction: A Systematic Review
Denno, D. M., VanBuskirk, K., Nelson, Z. C., Musser, C. A., Burgess, D. C. H., & Tarr, P. I. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu541 · Cited by 146
How to predict clinical relapse in inflammatory bowel disease patients
Liverani, E. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i3.1017 · Cited by 146
Intestinal permeability in patients with adverse reactions to food
Ventura, M. T., Polimeno, L., Amoruso, A., Gatti, F. L., Annoscia, E., Marinaro, M., Leo, E. D., Matino, M., Buquicchio, R., Bonini, S., et al. (2006) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.06.012 · Cited by 144
Mechanism of glucocorticoid regulation of the intestinal tight junction barrier
Boivin, M. A., Ye, D., Kennedy, J. C., Al–Sadi, R., Shepela, C., & Ma, T. Y. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00252.2006 · Cited by 142
Screening of sulfate-reducing bacteria in colonoscopy samples from healthy and colitic human gut mucosa
Zinkevich, V., & Beech, I. B. (2000) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2000.tb00764.x · Cited by 142
Systematic review: nutritional therapy in paediatric Crohn’s disease
Day, A. S., Whitten, K. E., Sidler, M. A., & Lemberg, D. A. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03578.x · Cited by 141
Commensal and Probiotic Bacteria Influence Intestinal Barrier Function and Susceptibility to Colitis in Nod1−/−;Nod2−/− Mice
Natividad, J. M. M., Petit, V., Huang, X., de Palma, G., Jury, J., Sanz, Y., Philpott, D., Garcia Rodenas, C. L., McCoy, K. D., & Verdu, E. F. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22848 · Cited by 139
Molecular pathogenesis of inflammatory bowel disease: Genotypes, phenotypes and personalized medicine
Goyette, P., Labbé, C., Trinh, T. T., Xavier, R. J., & Rioux, J. D. (2007) · Annals of Medicine · doi:10.1080/07853890701197615 · Cited by 141
Mechanisms of initiation and perpetuation of gut inflammation by stress
Hart, A., & Kamm, M. A. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01359.x · Cited by 138
The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guidelines: The use of tumor necrosis factor-alpha antagonist therapy in Inflammatory Bowel Disease☆
Orlando, A., Armuzzi, A., Papi, C., Annese, V., Ardizzone, S., Biancone, L., Bortoli, A., Castiglione, F., Renata D'Incà, & Gionchetti, P. (2010) · Digestive and Liver Disease · doi:10.1016/j.dld.2010.07.010 · Cited by 138
S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn”
Hoffmann, J., Preiß, J., Autschbach, F., Buhr, H. J., Häuser, W., Herrlinger, K. R., Höhne, W., Koletzko, S., Krieglstein, C. F., Kruis, W., et al. (2008) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2008-1027796 · Cited by 134
The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases
Jin, Y., & Blikslager, A. T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103550 · Cited by 139
Intestinal barrier healing is superior to endoscopic and histologic remission for predicting major adverse outcomes in inflammatory bowel disease: the prospective ERIca trial
Rath, T., Atreya, R., Bodenschatz, J., Uter, W., Geppert, C. E., Vitali, F., Fischer, S., Waldner, M. J., Colombel, J.-F., Hartmann, A., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2022.10.014 · Cited by 133
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli
Shawki, A., & McCole, D. F. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.10.004 · Cited by 142
Preventing postoperative recurrence of Crohn's disease
Borley, N. R., Mortensen, N. J. M., & Jewell, D. P. (1997) · British journal of surgery · doi:10.1002/bjs.1800841104 · Cited by 133
Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis
Nighot, P. K., Al–Sadi, R., Rawat, M., Guo, S., Watterson, D. M., & Ma, T. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00256.2015 · Cited by 132
Intestinal Barrier Dysfunction in Inflammatory Bowel Disease: Underpinning Pathogenesis and Therapeutics
Dunleavy, K. A., Raffals, L. E., & Camilleri, M. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-08122-w · Cited by 145
Inflammatory bowel disease: is it really just another break in the wall?: Figure 1
Weber, C. R., & Turner, J. R. (2006) · Gut · doi:10.1136/gut.2006.104182 · Cited by 132
Review article: new insights into the pathogenesis of radiation‐induced intestinal dysfunction
Macnaughton (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00745.x · Cited by 131
Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take “toll”
Lakatos, P. L. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i12.1829 · Cited by 131
Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease
Henderson, P., Limbergen, J. V., Schwarze, J., & Wilson, D. C. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21379 · Cited by 134
Stress impairs murine intestinal barrier function: improvement by glucagon-like peptide-2
Cameron, H. L., & Perdue, M. H. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085373 · Cited by 128
Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease
Abraham, C., Abreu, M. T., & Turner, J. R. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.12.288 · Cited by 129
Effect of zinc supplementation on intestinal permeability in experimental colitis
Sturniolo, G. C., Fries, W., Mazzon, E., Leo, V. D., Barollo, M., & Renata D'Incà (2002) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2002.123624 · Cited by 127
Interferon-γ and tumor necrosis factor-α disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction
Li, Q., Zhang, Q., Wang, M., Zhao, S., Ma, J., Luo, N., Li, N., Li, Y., Xu, G., & Li, J. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.08.017 · Cited by 126
Serum zonulin in patients with inflammatory bowel disease: a pilot study
Caviglia, G. P., Dughera, F., Ribaldone, D. G., Rosso, C., Abate, M. L., Pellicano, R., Bresso, F., Smedile, A., Saracco, G. M., & Astegiano, M. (2019) · Minerva Medica · doi:10.23736/s0026-4806.18.05787-7 · Cited by 124
Effect of Long‐Term Oral Glutamine Supplements on Small Intestinal Permeability in Patients With Crohn's Disease
Hond, E. D., Hiele, M. I., Peeters, M., Ghoos, Y. F., & Rutgeerts, P. J. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300107 · Cited by 124
Differential Effects of Flavonoids on Barrier Integrity in Human Intestinal Caco-2 Cells
Noda, S., Tanabe, S., & Suzuki, T. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300382h · Cited by 124
Gut Permeability, Intestinal Morphology, and Nutritional Depletion
van der Hulst, R. R. W. J., MEYENFELDT, M. F. V., KREEL, B. K. V., Thunnissen, E., Brummer, R. J., Arends, J., & Soeters, P. B. (1998) · Nutrition · doi:10.1016/s0899-9007(97)00385-7 · Cited by 122
Clinical significance of serum diamine oxidase activity in inflammatory bowel disease
Honzawa, Y., Nakase, H., Matsuura, M., & Chiba, T. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21588 · Cited by 121
The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity
Clara, I., Lix, L. M., Walker, J. R., Graff, L. A., Miller, N., Rogala, L., Rawsthorne, P., & Bernstein, C. N. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.197 · Cited by 119
The Clinical Importance of Campylobacter concisus and Other Human Hosted Campylobacter Species
Liu, F., Ma, R., Wang, Y., & Zhang, L. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00243 · Cited by 125
TNF‐α–induced intestinal epithelial cell shedding: implications for intestinal barrier function
Watson, A. J. M., & Hughes, K. R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06523.x · Cited by 119
MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions
Cichon, C., Sabharwal, H., Rüter, C., & Schmidt, M. A. (2014) · Tissue Barriers · doi:10.4161/21688362.2014.944446 · Cited by 118
Potential Benefits of Dietary Fibre Intervention in Inflammatory Bowel Disease
Wong, C., Harris, P., & Ferguson, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060919 · Cited by 116
Stress and animal models of inflammatory bowel disease—An update on the role of the hypothalamo–pituitary–adrenal axis
Reber, S. O. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.014 · Cited by 116
Glial‐derived neurotrophic factor regulates intestinal epithelial barrier function and inflammation and is therapeutic for murine colitis
Zhang, D. K., He, F. Q., Li, T., Pang, X. H., Cui, D. J., Xie, Q., Huang, X. L., & Gan, H. T. (2010) · The Journal of Pathology · doi:10.1002/path.2749 · Cited by 114
Microbial imbalance and intestinal pathologies: connections and contributions
Yang, Y., & Jobin, C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.016428 · Cited by 118
Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease
Noguchi, M., Hiwatashi, N., Liu, Z., & Toyota, T. (1998) · Gut · doi:10.1136/gut.43.2.203 · Cited by 112
Evaluation of inflammatory activity in Crohn’s disease and ulcerative colitis
Vilela, E. G. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i9.872 · Cited by 110
Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways
Priya, A., Saha, K., & Nighot, P. K. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae232 · Cited by 115
Abnormal intestinal permeability in Crohn's disease pathogenesis
Teshima, C., Dieleman, L. A., & Meddings, J. B. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06612.x · Cited by 108
Intestinal Barrier Permeability in Allergic Diseases
Niewiem, M., & Grzybowska‐Chlebowczyk, U. (2022) · Nutrients · doi:10.3390/nu14091893 · Cited by 107
The role of calprotectin in predicting endoscopic post-surgical recurrence in asymptomatic Crohn's disease: a comparison with ultrasound.
Orlando, A., Modesto, I., Castiglione, F., Scala, L., Scimeca, D., Rispo, A., Teresi, S., Mocciaro, F., Criscuoli, V. V., Marrone, C., et al. (2006) · PubMed · Cited by 106
Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease
Mehta, S. J., Nijhuis, A. M., Kumagai, T., Lindsay, J. O., & Silver, A. R. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1994-6 · Cited by 105
Mechanism of Interleukin-1β Induced-Increase in Mouse Intestinal Permeability In Vivo
Al–Sadi, R., Guo, S., Dokładny, K., Smith, M. A., Ye, D., Kaza, A., Watterson, D. M., & Ma, T. Y. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0031 · Cited by 105
The role of innate signaling in the homeostasis of tolerance and immunity in the intestine
Wells, J. M., Loonen, L. M. P., & Karczewski, J. M. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.08.008 · Cited by 105
Molecular Pathophysiology of Epithelial Barrier Dysfunction in Inflammatory Bowel Diseases
Lee, J., Wasinger, V. C., Yau, Y. Y., Chuang, E., Yajnik, V., & Leong, R. W. L. (2018) · Proteomes · doi:10.3390/proteomes6020017 · Cited by 102
Use of Probiotics in the Treatment of Inflammatory Bowel Disease
Hart, A. L., Stagg, A. J., & Kamm, M. A. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200302000-00005 · Cited by 102
A high serum concentration of interleukin-6 is predictive of relapse in quiescent Crohn??s disease
Louis, E. J., Bélaïche, J., Kemseke, C. V., Franchimont, D. P., Groote, D. D., Gueenen, V., & Mary, J. (1997) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199710000-00004 · Cited by 101
Bifidobacterium bifidum Ameliorates DSS-Induced Colitis in Mice by Regulating AHR/NRF2/NLRP3 Inflammasome Pathways through Indole-3-lactic Acid Production
Cui, Q., Zhang, Z., Tian, X., Liang, X., Lü, Y., Shi, Y., Kuerman, M., Wang, R., zhou, Y., Gong, P., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06894 · Cited by 103
Intestinal Barrier Function and Secretion in Methotrexate-Induced Rat Intestinal Mucositis
Carneiro‐Filho, B. A., Lima, I. P. F., Araujo, D., Cavalcante, M. C. M., Carvalho, G. H. P., Brito, G. A. D. C., Lima, V., Monteiro, S. M. N., Santos, F. N., Ribeiro, R. A., et al. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000011604.45531.2c · Cited by 100
Adherent-Invasive Escherichia coli Induce Claudin-2 Expression and Barrier Defect in CEABAC10 Mice and Crohnʼs Disease Patients§
Denizot, J., Sivignon, A., Barreau, F., Darcha, C., Chan, C. H. F., Stanners, C. P., Hofman, P. M., Darfeuille–Michaud, A., & Barnich, N. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21787 · Cited by 99
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M. (2006) · Retrovirology · doi:10.1186/1742-4690-3-s1-s98 · Cited by 98
Review article: Intestinal permeability in Crohn's disease
Meddings, J. B. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1997.tb00808.x · Cited by 98
Role of bacteria in experimental colitis
Guarner, F., & Malagelada, J. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00068-4 · Cited by 96
Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease
Renata D'Incà, Annese, V., Leo, V. D., Latiano, A., Quaino, V., Abazia, C., Vettorato, M. G., & Sturniolo, G. C. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02916.x · Cited by 95
Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy
Chen, K., Yang, M., Yue, N., Zhang, Y., Tian, C., Wei, D., Shi, R., Yao, J., Wang, L., & Li, D. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s470520 · Cited by 97
Leaky Gut in Patients with Diarrhea-Predominant Irritable Bowel Syndrome and Inactive Ulcerative Colitis
Gecse, K., Roka, R., Séra, T., Rosztóczy, A., Annaházi, A., Izbéki, F., Nagy, F., Molnár, T., Szepes, Z., Pávics, L., et al. (2011) · Digestion · doi:10.1159/000333083 · Cited by 88
The immunopathogenesis of Crohn's disease: a three-stage model
Sewell, G. W., Marks, D. J., & Segal, A. W. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.06.003 · Cited by 96
Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis
Nighot, M., Ganapathy, A. S., Saha, K., Suchanec, E., Castillo, E. F., Gregory, A. D., Shapiro, S. D., Ma, T., & Nighot, P. K. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab064 · Cited by 91
MicroRNA‐21 regulates intestinal epithelial tight junction permeability
Zhang, L., Shen, J., Cheng, J., & Fan, X. (2015) · Cell Biochemistry and Function · doi:10.1002/cbf.3109 · Cited by 90
Glucocorticoids regulate barrier function and claudin expression in intestinal epithelial cells via MKP-1
Fischer, A., Gluth, M., Weege, F., Pape, U., Wiedenmann, B., Baumgart, D. C., & Theuring, F. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00095.2013 · Cited by 92
Chasing a ghost? – Issues with the determination of circulating levels of endotoxin in human blood
Gnauck, A., Lentle, R. G., & Kruger, M. C. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1123215 · Cited by 91
Clinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87
The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy?
Pochard, C., Coquenlorge, S., Freyssinet, M., Naveilhan, P., Bourreille, A., Neunlist, M., & Rolli‐Derkinderen, M. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00016.2018 · Cited by 89
Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2
Maharshak, N., Huh, E. Y., Paiboonrungruang, C., Shanahan, M., Thurlow, L., Herzog, J., Djukic, Z., Orlando, R., Pawlinski, R., Ellermann, M., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00425-15 · Cited by 86
Tumor Necrosis Factor Alpha and Inflammation Disrupt the Polarity Complex in Intestinal Epithelial Cells by a Posttranslational Mechanism
Mashukova, A., Wald, F. A., & Salas, P. J. I. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00811-10 · Cited by 84
Contributions of intestinal epithelial barriers to health and disease
Choi, W., Yeruva, S., & Turner, J. R. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.036 · Cited by 84
Cellular and molecular mechanism of interleukin-1β modulation of Caco-2 intestinal epithelial tight junction barrier
Al–Sadi, R., Ye, D., Said, H. M., & Ma, T. Y. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01065.x · Cited by 83
Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism
Groschwitz, K. R., Wu, D. X.-Y., Osterfeld, H., Ahrens, R., & Hogan, S. P. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00186.2012 · Cited by 83
Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
Wine, E., Ossa, J. C., Gray‐Owen, S. D., & Sherman, P. M. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-180 · Cited by 83
Pregnane X receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibiting cytokine-induced myosin light-chain kinase expression and c-Jun N-terminal kinase 1/2 activation
Garg, A., Zhao, A., Erickson, S. L., Mukherjee, S., Lau, A. J., Alston, L., Chang, T. K. H., Mani, S., & Hirota, S. A. (2016) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.234096 · Cited by 82
Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model
Sturgeon, C., Lan, J., & Fasano, A. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13343 · Cited by 82
Salmonella Infection Upregulates the Leaky Protein Claudin-2 in Intestinal Epithelial Cells
Zhang, Y.-G., Wu, S., Xia, Y., & Sun, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058606 · Cited by 82
Increased small intestinal permeability in ulcerative colitis: Rather genetic than environmental and a risk factor for extensive disease?
Büning, C., Geissler, N., Prager, M., Sturm, A., Baumgart, D. C., Büttner, J., Bühner, S., Haas, V. K., & Lochs, H. H. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22909 · Cited by 82
Self-citation
Neuro‐glial crosstalk in inflammatory bowel disease
Neunlist, M., Landeghem, L. V., Bourreille, A., & Savidge, T. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01963.x · Cited by 82
The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions
Spalinger, M. R., Sayoc-Becerra, A., Ordookhanian, C., Canale, V., Santos, A. N., King, S. J., Krishnan, M., Nair, M. G., Scharl, M. M., & McCole, D. F. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa182 · Cited by 81
CCR6 Regulation of the Actin Cytoskeleton Orchestrates Human Beta Defensin-2- and CCL20-mediated Restitution of Colonic Epithelial Cells
Vongsa, R. A., Zimmerman, N. P., & Dwinell, M. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805289200 · Cited by 81
Mesenteric Blood Flow Is Related to Disease Activity and Risk of Relapse in Crohn's Disease: A Prospective Follow-Up Study
Ludwig, D., Wiener, S., Brüning, A., Schwarting, K., Jantschek, G., & Stange, E. F. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01442.x · Cited by 79

Authors: Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H.
Corresponding author: Lochs, H.
ORCID: Waldhoer, T.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1993-06
Volume: 341
Issue: 8858
Pages: 1437-1439
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/0140-6736(93)90882-h
OpenAlex: W2080195364
Cited by: 626
References: 16
Citations by year: 2026: 6 · 2025: 19 · 2024: 12 · 2023: 15 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 22 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 17 · 2012: 26
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: Crohn's disease, intestinal permeability, recurrence prediction, lactulose/mannitol test, permeability index, subclinical disease, pathogenesis, inflammatory bowel disease
MeSH terms: Adult, Crohn Disease, Female, Humans, Intestinal Mucosa, Lactulose, Male, Mannitol, Permeability, Predictive Value of Tests, Recurrence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intestinal permeability and the prediction of relapse in Crohn's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks