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Fetal nutrition and cardiovascular disease in adult life
Open accessAbstract
Babies who are small at birth or during infancy have increased rates of cardiovascular disease and non-insulin-dependent diabetes as adults. Some of these babies have low birthweights, some are small in relation to the size of their placentas, some are thin at birth, and some are short at birth and fail to gain weight in infancy. This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth. The fetuses' adaptations to undernutrition are associated with changes in the concentrations of fetal and placental hormones. Persisting changes in the levels of hormone secretion, and in the sensitivity of tissues to them, may link fetal undernutrition with abnormal structure, function, and disease in adult life.
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“Barker’s foundational work identified associations between undernutrition during gestation, low birth weight and higher rates of ischemic heart and coronary artery disease mortality in adulthood in British children born in the 1920s [38,39,40,41].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [41]
In the citing paper
“Thus, the DOHaD theory proposed that nutrient restriction during specific periods of development (e.g., conception, gestation and the first few years of life), when tissues and organs are particularly sensitive to environmental exposures, as a consequence influence the susceptibility for cardiovascular and metabolic diseases in adulthood [41,42,43].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [41]
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Metadata
- Authors
- Barker, D. J. P., Godfrey, K. M., Gluckman, P. D., Harding, J. E., Owens, J. A., & Robinson, J. S.
- Affiliations
- Southampton General Hospital (GB)
- University of Auckland (NZ)
- The University of Adelaide (AU)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1993-04
- Volume
- 341
- Issue
- 8850
- Pages
- 938-941
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2096601431
- Cited by
- 2,753
- References
- 53
- Citations by year
- 2026: 39 · 2025: 47 · 2024: 68 · 2023: 81 · 2022: 108 · 2021: 103 · 2020: 113 · 2019: 98 · 2018: 142 · 2017: 121 · 2016: 111 · 2015: 115 · 2014: 126 · 2013: 100 · 2012: 107
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- fetal malnutrition, fetal programming, cardiovascular disease, type 2 diabetes, low birth weight, small for gestational age, placental hormones, fetal growth, developmental origins of health and disease, hormone sensitivity
- MeSH terms
- Adult, Birth Weight, Body Height, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Fetal Growth Retardation, Humans, Hydrocortisone, Infant Nutrition Disorders, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, Nutrition Disorders, Pregnancy, Pregnancy Complications, Risk Factors
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