Synthesis and characterization of pH-sensitive poly(organophosphazene) hydrogels
Abstract
A new class of pH-sensitive hydrogels has been designed and synthesized. These are novel polyphosphazenes that bear various ratios of sodium oxybenzoate and methoxyethoxyethoxy side groups. These water-soluble macromolecules were cross-linked by 60Co gamma irradiation and the products were allowed to absorb water to form hydrogels. The hydrogels had higher equilibrium degrees of swelling in basic than in acidic buffer solutions, and polymers with a higher loading of the ionic side group showed higher swellability than those with a lower loading of this side group. The effects of ionic strength, cation charge and radiation dose on the degree of swelling were also studied. A study of the diffusion of the dye Biebrich Scarlet from the hydrogels showed complete release of the dye in 4-12 h in pH 7.4 buffer solution but significantly lower release at pH 2 even after 48 h. The release rate also varied as the side-group ratios were changed. The prehydrogel polymers were synthesized via the macromolecular substitution reactions of poly(dichlorophosphazene) with sodium methoxyethoxyethoxide and the sodium salt of propyl 4-hydroxybenzoate, followed by ester hydrolysis to yield the sodium carboxylate. The hydrogels are of interest for possible use as pH-sensitive membranes and for a number of potential biomedical applications.
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Polyphosphazenes with ethylene oxy side groups can be crosslinked with γ-rays to give hydrogels, which have been investigated as controlled drug release agents.
“Polyphosphazenes with ethylene oxy side groups can be crosslinked with γ -rays to give hydrogels, which have been investigated as controlled drug release agents [181 -185].”
From Ring-Opening Polymerization—An Introductory Review (2013) · cites this paper as [185]
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- Authors
- Allcock, H.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Allcock, H
- ORCID
- Allcock, H
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 1996
- Volume
- 17
- Issue
- 23
- Pages
- 2295-2302
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1974302740
- Cited by
- 80
- References
- 18
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 7 · 2012: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Army Research Office
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- polyphosphazenes, pH-responsive hydrogels, gamma irradiation crosslinking, swelling behavior, ionic strength effects, cationic charge, dye release, poly(dichlorophosphazene), pH-responsive membranes, biomedical applications
- MeSH terms
- Azo Compounds, Biocompatible Materials, Cations, Delayed-Action Preparations, Diffusion, Drug Carriers, Gamma Rays, Gels, Hydrogen-Ion Concentration, Hydrolysis, Materials Testing, Naphthols, Magnetic Resonance Spectroscopy, Organophosphorus Compounds, Osmolar Concentration, Polymers, Structure-Activity Relationship
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