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Cited by 82High Altitude and HypoxiaReproductive Physiology in LivestockPregnancy and preeclampsia studies

Ovine placentome morphology: Effect of high altitude, long-term hypoxia

Penninga, L., Longo, L.D.·1998·Placenta
DOI 10.1016/s0143-4004(98)90008-x
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Abstract

The effect of high altitude, long-term hypoxaemia on placentome morphology in the sheep was examined using singleton and twin pregnant ewes. Normoxic twins had lower fetal and placental weights (3.7+/-0.2 kg and 215+/-26 g, respectively) than normoxic singleton fetuses (4.3+/-0.2 kg and 336+/-17 g, respectively). Fetal and placental weights were similar in normoxic singleton and high altitude (3820 m) hypoxic singleton fetuses (4.3+/-0.2 and 4.4+/-0.4 kg, 336+/-17 and 342+/-62 g, respectively). The distribution of placentome types was classified into four major categories (A-D) and for normoxic singletons was as follows: A=76+/-4, B=22+/-3, C=1+/-2, and D=1+/-1. Normoxic twins tended to have more type B (type A=63+/-10, B=33+/-8, C=2+/-1, and D=2+/-1). High altitude hypoxic singletons had significantly fewer type A (33+/-4) and more type B (50+/-3), C (10+/-7), D (7+/-1) placentomes than normoxic singletons. In addition, in the sea-level control group, five animals were found to be spontaneously hypoxic with a placentome distribution similar to that of the high altitude hypoxic fetuses. In conclusion, both high altitude, long-term hypoxia and low altitude spontaneous hypoxia lead to a significant change in placentome distribution with less type A and increases in types B, C and D. Physiologically, the change in the several placentome types with high altitude hypoxia suggests an acclimatization response to optimize transplacental exchange efficiency.

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  • In pregnant sheep at high altitude, the luminal cross sectional area, but not the number, of maternal vessels in the placentomes is increased, which results in a greater percentage area of maternal blood vessels and normal fetal growth.

    “In pregnant sheep at high altitude, the luminal cross sectional area, but not the number, of maternal vessels in the placentomes is increased, which results in a greater percentage area of maternal blood vessels and normal fetal growth (317, 437).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [437]

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Authors
Penninga, L., & Longo, L. D.
Affiliations
  • Loma Linda University Medical Center (US)
  • Loma Linda University (US)
Corresponding author
Longo, L.D.
ORCID
Penninga, L.
Venue
Placenta
Publisher
Elsevier BV
Published
1998-03
Volume
19
Issue
2-3
Pages
187-193
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/s0143-4004(98)90008-x
OpenAlex
W2006120988
Cited by
82
References
55
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 2
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-03807, HD-13226, R01HD003807)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
high altitude, hypoxia, sheep, twin pregnancy, fetal weight, placental weight, acclimatization, placental histology
MeSH terms
Altitude, Animals, Hypoxia, Body Weight, Female, Gestational Age, Litter Size, Organ Size, Placenta, Pregnancy, Sheep

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