Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats
Abstract
In intact, non-ovariectomized female rats in spontaneous behavioral estrus, the i.c.v. injection of oxytocin significantly increased lordosis quotient and lordosis duration, starting from a dose of 1 ng/rat. On the other hand, the oxytocin antagonist, d(CH2)5Tyr(Me)-[Orn]8-vasotocin, injected at the same doses and by the same route, decreased lordosis quotient and lordosis duration, and prevented the effect of oxytocin. These data further support the notion that oxytocin plays a physiological role in female sexual receptivity.
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Reductions in both lordosis duration and quotient are noted following injection of an oxytocin antagonist.
“Reductions in both lordosis duration and quotient are noted following injection of an oxytocin antagonist (Benelli et al., 1994).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Benelli et al., 1994
Injections of oxytocin ICV increase lordosis duration and lordosis quotient in female rodents.
“Injections of oxytocin ICV increase lordosis duration and lordosis quotient (ratio of lordosis responses to male mounts, with increases in this ratio reflecting increases in female receptivity; Benelli et al., 1994).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Benelli et al., 1994
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Withuhn, T. F. (2004) · University Libraries (University of Maryland)
- Authors
- Benelli, A., Poggioli, R., Luppi, P., Ruini, L., Bertolini, A., & Arletti, R.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Arletti, R.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 1994-10
- Volume
- 27
- Issue
- 4
- Pages
- 245-250
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2018533048
- Cited by
- 39
- References
- 39
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, sexual receptivity, lordosis, arginine vasotocin, oxytocin antagonist, female sexual behavior, estrus, intracerebroventricular administration
- MeSH terms
- Animals, Female, Oxytocin, Posture, Sexual Behavior, Animal, Rats, Wistar, Statistics, Nonparametric, Rats
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