Estradiol Modulates Density of Putative Oxytocin Receptors’ in Discrete Rat Brain Regions

de Kloet, Ronald; Voorhuis, Door A.M.; Boschma, Ypie; Elands, Jack

doi:10.1159/000124680

Cited by 199Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

Estradiol Modulates Density of Putative Oxytocin Receptors’ in Discrete Rat Brain Regions

de Kloet, Ronald, Voorhuis, Door A.M., Boschma, Ypie, Elands, Jack·2008·Neuroendocrinology

DOI 10.1159/000124680

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Abstract

Previous studies have provided evidence for a discrete localization of two types of vasopressin (AVP)-labeled binding sites in the rat brain, i.e., regions labeled preferentially with AVP (putative AVP receptors) and regions labeled with AVP as well as oxytocin (OT). The latter binding sites are considered here as putative OT receptors. In the present study the effect of estradiol on the number of these putative receptor sites for OT and AVP was investigated in rat brain after daily subcutaneous administration of the steroid (10 µg/100 g body weight) to ovariectomized rats. Specific binding of [3H]-OT and [3H]-AVP was determined after in vitro incubation of frozen brain sections, autoradiography and quantitation of the images with computer-assisted densitometry. Estradiol increased the number of OT receptors at least 4-fold in the ventromedial nucleus of the hypothalamus, regions of the olfactory tubercle, the nucleus accumbens and occasionally in the organum vasculosum laminae terminalis. A smaller increase (two-fold) was noted in the central amygdala, while a tendency to a decrease in OT receptor number was noted in the olfactory nucleus and the ventral subiculum. Estradiol treatment permitted an estimation of binding constants of [3H]-OT-binding to a membrane fraction of microdissected ventromedial hypothalamic region {Kd: 1.3 nM, Bmax: 19.9 fmol/mg protein). The number of putative AVP receptors in the lateral septum and in the nucleus tractus solitarii was not affected by estradiol. In conclusion, the OT receptor system is subject to modulation by estradiol in some discrete brain regions, but not in others. One of the principal sites of this interaction is located in the ventromedial nucleus, which is a hypothalamic region known to contain a high density of estradiol receptors and to respond to estrogens by changes in ultrastructure, protein synthesis, electrophysiology and sexual behavior. The results show that estradiol may sensitize these processes to OT and AVP by increasing the number of putative OT receptors.

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Androgens and progesterone modulate oxytocin and oxytocin receptor expression, while estrogens seem to have the greatest impact on the oxytocin system.
“While androgens and progesterone modulate Oxt and Oxtr expression (72–75), it is the estrogens that seem to have the greatest impact on the Oxt system (68, 70, 74, 76–78).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [76]

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Authors: de Kloet, R., Voorhuis, D. A. M., Boschma, Y., & Elands, J.
Affiliations: Utrecht University (NL)
ORCID: Elands, Jack
Venue: Neuroendocrinology
Publisher: S. Karger AG
Published: 2008-04-01
Volume: 44
Issue: 4
Pages: 415-421
ISSN: 0028-3835 (ISSN-L)
1423-0194
DOI: 10.1159/000124680
OpenAlex: W2065807821
Cited by: 198
References: 0
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 1 · 2013: 9 · 2012: 2
FWCI: 8.02
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: estradiol, oxytocin receptor, vasopressin receptor, receptor density, ventromedial hypothalamus, olfactory tubercle, nucleus accumbens, organum vasculosum of the lamina terminalis, central amygdala, ventral subiculum, lateral septum, nucleus tractus solitarius, binding constant, ovariectomized rats
MeSH terms: Animals, Arginine Vasopressin, Brain Chemistry, Estradiol, Female, Neurosecretory Systems, Olfactory Bulb, Ovariectomy, Oxytocin, Rats, Inbred Strains, Receptors, Angiotensin, Ventromedial Hypothalamic Nucleus, Receptors, Oxytocin, Rats

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Estradiol Modulates Density of Putative Oxytocin Receptors’ in Discrete Rat Brain Regions

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