Oxytocin: Parallel Processing in the Social Brain?
Open accessAbstract
Early studies attempting to disentangle the network complexity of the brain exploited the accessibility of sensory receptive fields to reveal circuits made up of synapses connected both in series and in parallel. More recently, extension of this organisational principle beyond the sensory systems has been made possible by the advent of modern molecular, viral and optogenetic approaches. Here, evidence supporting parallel processing of social behaviours mediated by oxytocin is reviewed. Understanding oxytocinergic signalling from this perspective has significant implications for the design of oxytocin‐based therapeutic interventions aimed at disorders such as autism, where disrupted social function is a core clinical feature. Moreover, identification of opportunities for novel technology development will require a better appreciation of the complexity of the circuit‐level organisation of the social brain.
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Oxytocin is important for maternal physiology and childcare, including parturition and milk ejection during nursing.
“Oxytocin is a neuropeptide that is important for maternal physiology and childcare, including parturition and milk ejection during nursing1–6.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [6]
Central oxytocin release is involved in behaviours including reproduction, parental care and pair bonding.
“whereas oxytocin release in the central nervous system is involved in a wide range of behaviours including reproduction, parental care and pair bonding5,6.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [6]
Suckling triggers the release of oxytocin.
“Suckling triggers the release of oxytocin, but other sensory cues—specifically, infant cries—can increase the levels of oxytocin in new human mothers7”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [6]
Peripheral oxytocin is important for milk ejection during nursing and uterine contractions during labour.
“Peripheral oxytocin is important for milk ejection during nursing and uterine contractions during labour”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [6]
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Choleris, E., Little, S. R., Mong, J. A., Puram, S. V., Langer, R., & Pfaff, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700670104 · Cited by 183 · see citing works
Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Kawakubo, Y., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3181 · Cited by 183 · see citing works
Serotonin Receptors Involved in Vasopressin and Oxytocin Secretion
Jørgensen, H., Riis, M., Knigge, U., Kjær, A., & Warberg, J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00978.x · Cited by 182 · see citing works
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Oxytocin-dependent reopening of a social reward learning critical period with MDMA
Nardou, R., Lewis, E. M., Rothhaas, R., Xu, R., Yang, A., Boyden, E., & Dölen, G. (2019) · Nature · doi:10.1038/s41586-019-1075-9 · Cited by 334 · see citing works
Self-citationNeural circuitry for maternal oxytocin release induced by infant cries
Valtcheva, S., Issa, H. A., Bair-Marshall, C. J., Martin, K. A., Jung, K., Zhang, Y., Kwon, H.-B., & Froemke, R. C. (2023) · Nature · doi:10.1038/s41586-023-06540-4 · Cited by 115 · see citing works
Parallel social information processing circuits are differentially impacted in autism
Lewis, E. M., Stein-O’Brien, G. L., Patino, A. V., Nardou, R., Grossman, C. D., Brown, M., Bangamwabo, B., Ndiaye, N., Giovinazzo, D., Dardani, I., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.10.002 · Cited by 72 · see citing works
Self-citationWinokur, S. B., Caslin, A. Y., Davis, F. M., & Froemke, R. C. (2025) · Current Biology · doi:10.1016/j.cub.2025.08.059 · Cited by 7 · see citing works
- Authors
- Dölen, G.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Dölen, Gül
- ORCID
- Dölen, Gül
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2015-05-26
- Volume
- 27
- Issue
- 6
- Pages
- 516-535
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1980183526
- Semantic Scholar
- 80fd100735b42c0085f83bb1baa28e909cd9100d
- Cited by
- 65
- References
- 346
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 20 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 3 · 2013: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroendocrinology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Hartwell Foundation
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- oxytocin, parallel computing, social brain, social behavior, neural circuits, autism spectrum disorder, social dysfunction, therapeutic interventions, optogenetics, viral tracing
- MeSH terms
- Adolescent, Adult, Brain, Child, Humans, Male, Memory, Oxytocin, Social Behavior, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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