Gonadal steroids regulate oxytocin receptors but not vasopressin receptors in the brain of male and female rats. An autoradiographical study
Abstract
The distribution and the amount of [3H]oxytocin binding were studied in the brain of adult rats of either sex, as well as in male and female castrates, some of which received injections of estradiol or testosterone. Intact males were treated with an aromatase inhibitor. Castration and inhibition of aromatase activity reduced, whereas estradiol and testosterone increased oxytocin binding, particularly in regions of the brain assumed to be involved in reproductive functions, such as the ventrolateral part of the hypothalamic ventromedial nucleus and the islands of Calleja and neighbouring cell groups. Binding of oxytocin to the uterus was also estrogen-dependent. In the same animals, we also studied the distribution of [3H]vasopressin binding sites present in the brain. It was similar in males and females, and was not affected by experimentally manipulating gonadal hormone levels. In immunocytochemical studies we noticed, as others had previously, that the vasopressin content of certain areas of the rat brain was affected by castration, whereas the oxytocin innervation was not. These results are discussed in relation to the possible functions of oxytocin in the brain and of the lack of correspondence between the immunocytochemical and the autoradiographic data.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gonadal steroids play a significant role in regulating oxytocin activity.
“It is well established that gonadal steroids play a significant role in regulating Oxt activity (68–71).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [71]
Cites
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494 · see citing works
The vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522 · see citing works
Molecular cloning and charcterization of rat estrogen receptor cDNA
Koike, S., Sakai, M., & Muramatsu, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.6.2499 · Cited by 489 · see citing works
Pfaff, D. W., & Sakuma, Y. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012690 · Cited by 465 · see citing works
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442 · see citing works
Self-citationDistribution and regulation of aromatase activity in the rat hypothalamus and limbic system
ROSELLI, C. E., HORTON, L. E., & RESKO, J. A. (1985) · Endocrinology · doi:10.1210/endo-117-6-2471 · Cited by 415 · see citing works
Pfaff, D. W., & Sakuma, Y. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012691 · Cited by 350 · see citing works
Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000124125 · Cited by 322 · see citing works
De Vries, G. J., Buds, R. M., & Swaab, D. F. (1981) · Brain Research · doi:10.1016/0006-8993(81)90989-6 · Cited by 319 · see citing works
van Leengoed, E., Kerker, E., & Swanson, H. H. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1120275 · Cited by 300 · see citing works
Hughes, J. T. (1978) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.41.1.96 · Cited by 269 · see citing works
Fuchs, A., Periyasamy, S., Alexandrová, M., & Soloff, M. S. (1983) · Endocrinology · doi:10.1210/endo-113-2-742 · Cited by 251 · see citing works
Vasopressin : principles and properties
Gash, D. M., & Boer, G. J. (1987) · Plenum Press eBooks · Cited by 250 · see citing works
van Leeuwen, F. W., Caffe, A. R., & Vries, G. J. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90348-8 · Cited by 248 · see citing works
Regulation of Brain Aromatase Activity in Rats*
Roselli, C. E., Ellinwood, W. E., & Resko, J. A. (1984) · Endocrinology · doi:10.1210/endo-114-1-192 · Cited by 233 · see citing works
Oxytocin facilitates the sexual receptivity of estrogen-treated female rats
Caldwell, J. D., Prange, A. J., & Pedersen, C. A. (1986) · Neuropeptides · doi:10.1016/0143-4179(86)90093-4 · Cited by 229 · see citing works
Tribollet, E., Charpak, S., Schmidt, A., Dubois-Dauphin, M., & Dreifuss, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01764.1989 · Cited by 228 · see citing works
Self-citationEstradiol Modulates Density of Putative Oxytocin Receptors’ in Discrete Rat Brain Regions
de Kloet, R., Voorhuis, D. A. M., Boschma, Y., & Elands, J. (2008) · Neuroendocrinology · doi:10.1159/000124680 · Cited by 198 · see citing works
Freund-Mercier, M. J., Stoeckel, M. E., Palacios, J. M., Pazos, A., Reichhart, J. M., Porte, A., & Richard, P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90113-8 · Cited by 192 · see citing works
Oxytocin-induced penile erection and yawning: site of action in the brain
Melis, M. R., Argiolas, A., & Gessa, G. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)91485-x · Cited by 190 · see citing works
Jansson, J., Ekberg, S., Isaksson, O. G. P., & Edén, S. (1984) · Endocrinology · doi:10.1210/endo-114-4-1287 · Cited by 184 · see citing works
Uterine receptor for oxytocin: Effects of estrogen
Soloff, M. S. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(75)80080-5 · Cited by 183 · see citing works
Oxytocin stimulates lordosis behavior in female rats
Arletti, R., & Bertolini, A. (1985) · Neuropeptides · doi:10.1016/0143-4179(85)90095-2 · Cited by 179 · see citing works
Oxytocin and sexual behaviour in the male rat and rabbit
Stoneham, M. D., Everitt, B. J., Hansen, S., Lightman, S. L., & Todd, K. (1985) · Journal of Endocrinology · doi:10.1677/joe.0.1070097 · Cited by 160 · see citing works
Audigier, S., & Barberis, C. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03794.x · Cited by 156 · see citing works
Self-citationOxytocin in the central nervous system and sexual behaviour in male rats
Hughes, A. M., Everitt, B. J., Lightman, S. L., & Todd, K. (1987) · Brain Research · doi:10.1016/0006-8993(87)91333-3 · Cited by 140 · see citing works
The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats
Argiolas, A., Collu, M., Gessa, G. L., Melis, M. R., & Serra, G. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90675-9 · Cited by 125 · see citing works
Oxytocin: an extremely potent inducer of penile erection and yawning in male rats
Argiolas, A., Melis, M. R., & Gessa, G. L. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90277-3 · Cited by 124 · see citing works
Postpartum Increases in Brain Oxytocin Binding
Insel, T. R. (2008) · Neuroendocrinology · doi:10.1159/000124694 · Cited by 116 · see citing works
Estradiol induces oxytocin binding sites in rat hypothalamic ventromedial nucleus
de Kloet, E. R., Voorhuis, T. A. M., & Elands, J. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90679-x · Cited by 116 · see citing works
Estradiol influences oxytocin-immunoreactive brain systems
Jirikowski, G. F., Caldwell, J. D., Pedersen, C. A., & Stumpf, W. E. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90022-x · Cited by 111 · see citing works
Regional Specificity of Gamma-Aminobutyric Acid Receptor Regulation by Estradiol
O’Connor, L. H., Nock, B. L., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000124958 · Cited by 110 · see citing works
Characterization of a uterine-type oxytocin receptor in the rat hippocampus.
Mühlethaler, M., Sawyer, W. H., Manning, M., & Dreifuss, J. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.21.6713 · Cited by 106 · see citing works
Self-citationBuijs, R. M., Pévet, P., Masson‐Pévet, M., Pool, C. W., Vries, G. J. D., Canguilheim, B., & VIVIEN‐ROELS, B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90829-2 · Cited by 106 · see citing works
Regulation of high-affinity GABAA receptors in the dorsal hippocampus by estradiol and progesterone
Schumacher, M., Coirini, H., & McEwen, B. S. (1989) · Brain Research · doi:10.1016/0006-8993(89)90955-4 · Cited by 103 · see citing works
Shewey, L. M., & Dorsa, D. M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-05-01671.1988 · Cited by 101 · see citing works
Maggi, M., Malozowski, S., Kassis, S., Guardabasso, V., & Rodbard, D. (1987) · Endocrinology · doi:10.1210/endo-120-3-986 · Cited by 100 · see citing works
Akaishi, T., & Sakuma, Y. (1985) · Brain Research · doi:10.1016/0006-8993(85)90481-0 · Cited by 99 · see citing works
Regulation of oxytocin receptor concentration in rat uterine explants by estrogen and progesterone
Soloff, M. S., Fernström, M. A., Periyasamy, S., Soloff, S. L., Baldwin, S., & Wieder, M. (1983) · Canadian Journal of Biochemistry and Cell Biology · doi:10.1139/o83-078 · Cited by 98 · see citing works
Oxytocin-induced facilitation of lordosis behaviour in rats is progesterone-dependent
Gorzalka, B. B. (1987) · Neuropeptides · doi:10.1016/0143-4179(87)90089-8 · Cited by 97 · see citing works
Regulation of neuronal oxytocin mRNA by ovarian steroids in the mature and developing hypothalamus.
Miller, F. D., Ozimek, G., Milner, R. J., & Bloom, F. E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2468 · Cited by 95 · see citing works
Johnson, A. E., Coirini, H., Ball, G. F., & McEwen, B. S. (1989) · Endocrinology · doi:10.1210/endo-124-1-207 · Cited by 94 · see citing works
[3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors
Elands, J., Barberis, C., & Jard, S. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.1.e31 · Cited by 88 · see citing works
Estrogen‐Induced Up‐Regulation of γ‐Aminobutyric Acid Receptors in the CNS of Rodents
Maggi, A. C., & Pérez, J. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb13090.x · Cited by 82 · see citing works
Dreifuss, J. J., Raggenbass, M., Charpak, S., Dubois‐Dauphin, M., & Tribollet, E. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90089-5 · Cited by 76 · see citing works
Self-citationCaldwell, J. D., Jirikowski, G. F., Greer, E. R., Stumpf, W. E., & Pedersen, C. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90882-7 · Cited by 76 · see citing works
Vasopressin Localization and Putative Functions in the Brain
Buijs, R. M. (1987) · Springer eBooks · doi:10.1007/978-1-4615-8129-1_2 · Cited by 70 · see citing works
Raggenbass, M., Tribollet, E., Dubois‐Dauphin, M., & Dreifuss, J. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03929.1989 · Cited by 61 · see citing works
Self-citationRaggenbass, M., Tribollet, E., Dubois‐Dauphin, M., & Dreifuss, J. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.750 · Cited by 59 · see citing works
Self-citationEstrogen treatment increases the density of D1 dopamine receptors in the rat striatum
Hruska, R. E., & Nowak, M. W. (1988) · Brain Research · doi:10.1016/0006-8993(88)91523-5 · Cited by 59 · see citing works
Direct excitatory action of vasopressin in the lateral septum of the rat brain
Raggenbass, M., Dubois‐Dauphin, M., Tribollet, E., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)90286-7 · Cited by 57 · see citing works
Self-citationSnijdewint, F. G. M., van Leeuwen, F. W. B., & Gj, B. (1989) · PubMed · Cited by 56 · see citing works
Vasopressin excites ventromedial hypothalamic glucose-responsive neurons In vitro
Kow, L.-W., & Pfaff, D. W. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90398-7 · Cited by 54 · see citing works
Estrogen Alters the Diurnal Rhythm of α1-Adrenergic Receptor Densities in Selected Brain Regions*
Weiland, N. G., & Wise, P. M. (1987) · Endocrinology · doi:10.1210/endo-121-5-1751 · Cited by 51 · see citing works
Dubois‐Dauphin, M., Tribollet, E., & Dreifuss, J. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)91051-2 · Cited by 50 · see citing works
Self-citationDistribution and synaptic release of oxytocin in the central nervous system
Buijs, R. M., Vries, G. J. D., & van Leeuwen, F. W. (1985) · Data Archiving and Networked Services (DANS) · Cited by 50 · see citing works
Olsen, K. L., Edwards, E., Schechter, N., & Whalen, R. E. (1988) · Brain Research · doi:10.1016/0006-8993(88)91259-0 · Cited by 49 · see citing works
Presence of a Neural Mechanism for the Expression of Female Sexual Behaviors in the Male Rat Brain
Yamanouchi, K., & Arai, Y. (2008) · Neuroendocrinology · doi:10.1159/000124104 · Cited by 39 · see citing works
Freund‐Mercier, M. J., Dietl, M. M., Stoeckel, M. E., Palacios, J. M., & Richard, P. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90144-3 · Cited by 38 · see citing works
Modulation of hippocampal LHRH receptors by sex steroids in the rat
Badr, M., Marchetti, B., & Pelletier, G. (1988) · Peptides · doi:10.1016/0196-9781(88)90283-5 · Cited by 37 · see citing works
Johnson, A. E., Nock, B. L., McEwen, B. S., & Feder, H. H. (1988) · Brain Research · doi:10.1016/0006-8993(88)91505-3 · Cited by 32 · see citing works
Dubois‐Dauphin, M., & Zakarian, S. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90046-7 · Cited by 28 · see citing works
Self-citationPeripheral aromatization: Studies on controlling factors
Longcope, C. (1987) · Steroids · doi:10.1016/0039-128x(83)90076-4 · Cited by 26 · see citing works
The effects of estradiol and mestranol on alpha-adrenoceptors in select regions of the rat brain
Shackelford, D. P., McConnaughey, M. M., & Iams, S. G. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90249-3 · Cited by 17 · see citing works
Mapping and Analysis of Receptors for Neurohypophyseal Peptides Present in the Brain
Tribollet, E., Barberis, C., Jard, S., Elands, J., Dubois‐Dauphin, M., Marguerat, A., & Dreifuss, J. J. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5502-1_10 · Cited by 13 · see citing works
Self-citationEleftheriou, B. E. (2008) · Neuroendocrinology · doi:10.1159/000121921 · Cited by 2 · see citing works
Flagged first, then by citations
2 of the 69 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Neuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“In further support, we found sex differences in areas that may not be sensitive to gonadal steroids (Tribollet et al., 1990), such as the cortex, caudate putamen and hippocampal CA1 (Dumais et al., 2013).”
BackgroundInfluentialInsel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487 · see citing works
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00776.x · Cited by 415 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
Self-citationNeumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285 · see citing works
Activity-dependent neuronal-glial and synaptic plasticity in the adult mammalian hypothalamus
Theodosis, D. T., & Poulain, D. A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90002-w · Cited by 273 · see citing works
Engelmann, M., Wotjak, C. T., Neumann, I. D., Ludwig, M., & Landgraf, R. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00059-3 · Cited by 267 · see citing works
Young, L. J., Winslow, J., Nilsen, R., & Insel, T. R. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.3.599 · Cited by 235 · see citing works
Testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus
Delville, Y., Mansour, K. M., & Ferris, C. F. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02246-5 · Cited by 218 · see citing works
Oxytocin and Vasopressin Receptors and Species-Typical Social Behaviors
Young, L. J. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1548 · Cited by 211 · see citing works
Insel, T. R., Gelhard, R., & Shapiro, L. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90321-e · Cited by 209 · see citing works
Sexual dimorphism in the mammalian limbic system
Madeira, M. D., & Lieberman, A. R. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00052-j · Cited by 202 · see citing works
Dumais, K. M., Bredewold, R., Mayer, T. E., & Veenema, A. H. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.08.012 · Cited by 201 · see citing works
Albers, H. E. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.07.001 · Cited by 200 · see citing works
Uvnäs‐Moberg, K., & Petersson, M. (2005) · Zeitschrift für psychosomatische Medizin und Psychotherapie · doi:10.13109/zptm.2005.51.1.57 · Cited by 200 · see citing works
Gossen, A., Hahn, A., Westphal, L., Prinz, S., Schultz, R. T., Gründer, G., & Spreckelmeyer, K. N. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.07.001 · Cited by 189 · see citing works
Central administration of oxytocin modulates the infant rats response to social isolation
Insel, T. R., & Winslow, J. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90806-2 · Cited by 185 · see citing works
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
Chapter 1.1 Anatomy and function of extrahypothalamic vasopressin systems in the brain
Vries, G. J. D., & MILLER, M. A. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61558-7 · Cited by 183 · see citing works
Developmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 177 · see citing works
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Oxytocin administration, salivary testosterone, and father–infant social behavior
Weisman, O., Zagoory‐Sharon, O., & Feldman, R. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.006 · Cited by 160 · see citing works
Endogenous oxytocin is involved in short-term olfactory memory in female rats
Engelmann, M., Ebner, K., Wotjak, C. T., & Landgraf, R. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00084-3 · Cited by 156 · see citing works
TRIBOLLET, E., DUBOIS‐DAUPHIN, M., DREIFUSS, J. J., BARBERIS, C., & JARD, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34343.x · Cited by 156 · see citing works
Self-citationSmith, C. J. W., Poehlmann, M. L., Li, S., Ratnaseelan, A. M., Bredewold, R., & Veenema, A. H. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1260-7 · Cited by 143 · see citing works
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 140 · see citing works
Gould, B. R., & Zingg, H. H. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00283-5 · Cited by 138 · see citing works
Wang, Z., Young, L. J., Liu, Y., & Insel, T. R. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970224)378:4 · Cited by 135 · see citing works
Differential lateral septal vasopressin innervation in aggressive and nonaggressive male mice
Compaan, J. C., Buijs, R. M., Pool, C. W., De Ruiter, A. J. H., & koolhaas, J. M. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90032-7 · Cited by 135 · see citing works
Endocrine induced changes in brain function during pregnancy
Brunton, P. J., & Russell, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.062 · Cited by 134 · see citing works
Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity
Ochedalski, T., Subburaju, S., Wynn, P. C., & Aguilera, G. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01525.x · Cited by 133 · see citing works
The role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., et al. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90021-3 · Cited by 133 · see citing works
Vasudevan, N., Ogawa, S., & Pfaff, D. (2002) · Physiological Reviews · doi:10.1152/physrev.00014.2002 · Cited by 129 · see citing works
The Neurobiology of Social Affiliation and Pair Bonding
Carter, C. S., & Keverne, E. B. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00004-8 · Cited by 128 · see citing works
Beech, A. R., & Mitchell, I. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.10.002 · Cited by 127 · see citing works
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
Veening, J. G., A, T. R. D. J., & Barendregt, H. P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.05.004 · Cited by 126 · see citing works
Sexually dimorphic expression of oxytocin binding sites in forebrain and spinal cord of the rat
Uhl-Bronner, S., Waltisperger, E., Martínez-Lorenzana, G., Condes Lara, M., & Freund-Mercier, M. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.025 · Cited by 123 · see citing works
Oxytocin and the social brain: Neural mechanisms and perspectives in human research
Kanat, M., Heinrichs, M., & Domes, G. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.003 · Cited by 122 · see citing works
Toward a Neurobiology of Attachment
Insel, T. R. (2000) · Review of General Psychology · doi:10.1037/1089-2680.4.2.176 · Cited by 122 · see citing works
Cloning, Novel Promoter Sequence, and Estrogen Regulation of a Rat Oxytocin Receptor Gene
Bale, T. L., & Dorsa, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.3.4998 · Cited by 118 · see citing works
Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis
Borland, J. M., Rilling, J. K., Frantz, K. J., & Albers, H. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0129-2 · Cited by 116 · see citing works
Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion
Mecenas, C. A., Giussani, D. A., Owiny, J. R., Jenkins, S. L., Wu, W. X., Honnebier, B. O., Lockwood, C. J., Kong, L., Guller, S. M., & Nathanielsz, P. W. (1996) · Nature Medicine · doi:10.1038/nm0496-443 · Cited by 114 · see citing works
Gonadal steroids have paradoxical effects on brain oxytocin receptors
Insel, T. R., Young, L., Witt, D. M., & Crews, D. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00531.x · Cited by 113 · see citing works
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113 · see citing works
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113 · see citing works
Oxytocin and Vasopressin: Genetics and Behavioral Implications
Caldwell, H. K., & Young, W. S. (2006) · Springer eBooks · doi:10.1007/0-387-30395-2_25 · Cited by 113 · see citing works
The Neurobiology of Social Affiliation and Pair Bonding
Carter, C. S., & Keverne, E. B. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50006-8 · Cited by 109 · see citing works
Gi/o-Protein Coupled Receptors in the Aging Brain
de Oliveira, P. G., Ramos, M. L., Amaro, A. J. M., Dias, R. A., & Vieira, S. I. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00089 · Cited by 106 · see citing works
Wang, H., Ward, A., & Morris, J. F. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00186-m · Cited by 106 · see citing works
Bale, T. L. (1995) · Endocrinology · doi:10.1210/en.136.1.27 · Cited by 102 · see citing works
Differential Lateral Septal Vasopressin in Wild-type Rats: Correlation with Aggression
Everts, H. G. J., de Ruiter, A. J. H., & Koolhaas, J. M. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1375 · Cited by 102 · see citing works
Broad, K. D., Lévy, F., Evans, G., Kimura, T., Keverne, E. B., & Kendrick, K. M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00782.x · Cited by 100 · see citing works
Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle
Bale, T., Dorsa, D. M., & Johnston, C. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05058.1995 · Cited by 98 · see citing works
Zuloaga, D. G., Heck, A., Guzman, R. M. D., & Handa, R. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00319-2 · Cited by 96 · see citing works
Oxytocin-induced excitation of neurones in the rat central and medial amygdaloid nuclei
Terenzi, M. G., & Ingram, C. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.004 · Cited by 91 · see citing works
Oxytocin Receptor Binding in Female Prairie Voles: Endogenous and Exogenous Oestradiol Stimulation
Witt, D. M., Carter, C. S., & Lnsel, T. R. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00258.x · Cited by 91 · see citing works
Windle, R. J., Gamble, L. E., Kershaw, Y. M., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2006) · Endocrinology · doi:10.1210/en.2005-1079 · Cited by 90 · see citing works
Crowley, R. S., Insel, T. R., O’Keefe, J. A., Kim, N. B., & Amico, J. A. (1995) · Endocrinology · doi:10.1210/endo.136.1.7828535 · Cited by 89 · see citing works
Young, L. J., Wang, Z., Cooper, T. T., & Albers, H. E. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00573.x · Cited by 88 · see citing works
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 82 · see citing works
Krémarik, P., Freund‐Mercier, M. J., & Stoeckel, M. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330304 · Cited by 80 · see citing works
Crowley, R. S., & Amico, J. A. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243294 · Cited by 79 · see citing works
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79 · see citing works
Husarova, V. M., Lakatošová, S., Pivovarciova, A., Babinská, K., Bakoš, J., Durdiaková, J., Kubranská, A., Ondrejka, I., & Ostatníková, D. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.2.174 · Cited by 78 · see citing works
Expression and Region-Specific Regulation of the Oxytocin Receptor Gene in Rat Brain
Breton, C., & Zingg, H. H. (1997) · Endocrinology · doi:10.1210/endo.138.5.5127 · Cited by 78 · see citing works
Johnson, A. E., Audigier, S., Rossi, F., Jard, S., Tribollet, E., & Barberis, C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90795-o · Cited by 77 · see citing works
Self-citationPatchev, V. K., Schlosser, S. F., Hassan, A. H., & Almeida, O. F. X. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90003-x · Cited by 77 · see citing works
Tribollet, E., Barberis, C., & Arsenijévic, Y. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00591-x · Cited by 76 · see citing works
Self-citationWang, Z., Toloczko, D., Young, L. J., Moody, K., Newman, J. D., & Insel, T. R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00636-7 · Cited by 75 · see citing works
Testosterone, oxytocin, and the development of human parental care
Gordon, I., Pratt, M., Bergunde, K., Zagoory‐Sharon, O., & Feldman, R. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.05.016 · Cited by 75 · see citing works
Oxytocin receptor expression patterns in the human brain across development
Rokicki, J., Kaufmann, T., de Lange, A. G., van der Meer, D., Bahrami, S., Sartorius, A. M., Haukvik, U. K., Steen, N. E., Schwarz, E., Stein, D. J., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01305-5 · Cited by 74 · see citing works
Olazábal, D. E., & Alsina‐Llanes, M. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.04.006 · Cited by 72 · see citing works
Oxytocin alleviates hepatic ischemia–reperfusion injury in rats
Düşünceli, F., İşeri, S. Ö., Ercan, F., Gedik, N., Yeğen, C., & Yeğen, B. Ç. (2008) · Peptides · doi:10.1016/j.peptides.2008.02.010 · Cited by 70 · see citing works
Hormonal Processes in the Development and Expression of Aggressive Behavior
Simon, N. G. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50007-x · Cited by 69 · see citing works
Differential expression of oxytocin receptor mRNA in the developing rat brain
YOSHIMURA, R., Kimura, T., Watanabe, D., & Kiyama, H. (1996) · Neuroscience Research · doi:10.1016/0168-0102(95)01003-3 · Cited by 68 · see citing works
Vasopressin interactions with oxytocin in the control of female sexual behavior
Pedersen, C. A., & Boccia, M. L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.002 · Cited by 68 · see citing works
Oxytocin Involvement in Male and Female Sexual Behavior
Arletti, R., Benelli, A., & Bertolini, A. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34354.x · Cited by 66 · see citing works
Bale, T. L., & Dorsa, D. M. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588251 · Cited by 65 · see citing works
Vasudevan, N., Davidkova, G., Zhu, Y., Koibuchi, N., Chin, W. W., & Pfaff, D. W. (2001) · Neuroendocrinology · doi:10.1159/000054698 · Cited by 65 · see citing works
Oxytocin and rodent sociosexual responses: from behavior to gene expression
M.Witt, D. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00006-z · Cited by 64 · see citing works
Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys
Cavanaugh, J., Carp, S. B., Rock, C. M., & French, J. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.027 · Cited by 64 · see citing works
Oxytocin-induced inhibition of feeding and drinking: No sexual dimorphism in rats
Benelli, A., Bertolini, A., & Arletti, R. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90040-p · Cited by 61 · see citing works
Weisman, O., Pelphrey, K. A., Leckman, J. F., Feldman, R., Lu, Y., Chong, A., Chen, Y., Monakhov, M. V., Chew, S. H., & Ebstein, R. P. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.007 · Cited by 60 · see citing works
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
Tribollet, E., Barberis, C., Dubois‐Dauphin, M., & Dreifuss, J. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91156-9 · Cited by 58 · see citing works
Self-citationDubois-Dauphin, M., Barberis, C., & de Bilbao, F. (1996) · Brain Research · doi:10.1016/s0006-8993(96)01019-0 · Cited by 57 · see citing works
Self-citationINSEL, T. R., YOUNG, L., & WANG, Z. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51928.x · Cited by 56 · see citing works
The interplay of oxytocin and sex hormones
Quintana, D. S., Glaser, B. D., Kang, H., Kildal, E. S.-M., Audunsdottir, K., Sartorius, A. M., & Barth, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105765 · Cited by 54 · see citing works
Wang, Z., & Young, L. J. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00138-7 · Cited by 54 · see citing works
Oxytocin receptor binding in the hypothalamus during gestation in rats
Bealer, S. L., Lipschitz, D. L., Ramoz, G., & Crowley, W. R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00766.2005 · Cited by 54 · see citing works
Baracz, S. J., Everett, N. A., & Cornish, J. L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.014 · Cited by 52 · see citing works
Ehret, G., & Buckenmaier, J. (1994) · Journal of Physiology-Paris · doi:10.1016/0928-4257(94)90012-4 · Cited by 51 · see citing works
Mittaud, P., Labourdette, G., Zingg, H. H., & Guénot, D. (2001) · Glia · doi:10.1002/glia.10029 · Cited by 49 · see citing works
Aged rats are still responsive to the antidepressant and memory-improving effects of oxytocin
Arletti, R., Benelli, A., Poggioli, R., Luppi, P., Menozzi, B., & Bertolini, A. (1995) · Neuropeptides · doi:10.1016/0143-4179(95)90021-7 · Cited by 48 · see citing works
Role of oxytocin in parental behaviour
Olazábal, D. E. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12594 · Cited by 47 · see citing works
- Authors
- Tribollet, E., Audigier, S., Dubois-Dauphin, M., & Dreifuss, J. J.
- Affiliations
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Tribollet, Eliane
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-03
- Volume
- 511
- Issue
- 1
- Pages
- 129-140
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1970879453
- Cited by
- 203
- References
- 69
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 29.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin receptor, vasopressin receptor, sex steroids, estradiol, testosterone, aromatase inhibition, castration, sex differences, ventromedial hypothalamus, islands of Calleja, uterus, reproductive function
- MeSH terms
- Animals, Arginine Vasopressin, Autoradiography, Brain, Estradiol, Female, Male, Oxytocin, Rats, Inbred Strains, Receptors, Angiotensin, Testosterone, Receptors, Vasopressin, Receptors, Oxytocin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review