The DOI matches its Crossref record; 321 of the 327 references it cites were found in a registry or an index.
Restraint stress in biomedical research: A review
Abstract
The use of restraint or immobilization for investigations of animal physiology, pathology and pharmacology has an extensive history. The major use of this technique has been as a "stressor" for the induction of stress response syndromes in animals. Many such syndromes have been characterized from the behavioral level to the neurochemical concomitants of stress. As a consequence of this particular use of the restraint procedure, much information concerning drug effects on stress response syndromes has been obtained. Indeed, many researchers in the area of gastrointestinal drugs routinely screen their new compounds in a restraint model of gastric stress ulcer. The purpose of this review is to present for researchers, a summary of the methods for, the parameters of, and known drug effects on, restraint-induced pathology. In our experience, this technique has proven to be a very useful one for the examination of both central and peripheral mechanisms of stress-related disorders, as well as for studying drug effects upon these disorders.
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“Our study shows that rodents behave pro-socially when they perceive a conspecific experiencing non-painful psychological restraint stress (8, 9), acting to end that distress through deliberate action.”
From Empathy and pro-social behavior in rats (2011) · cites this paper as [9]
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Cited by
Sorted by citations
Empathy and pro-social behavior in rats
Bartal, I. B.-A., Decety, J., & Mason, P. (2011) · Science · doi:10.1126/science.1210789 · Cited by 934
Gong, S., Miao, Y.-L., Jiao, G.-Z., Sun, M.-J., Li, H., Lin, J., Luo, M.-J., & Tan, J.-H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117503 · Cited by 460
Restraint stress in biobehavioral research: Recent developments
Buynitsky, T., & Mostofsky, D. I. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.004 · Cited by 426
Restraint stress in biomedical research: An update
Glavin, G. B., Paré, W. P., Sandbak, T., Bakke, H.-K., & Murison, R. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90027-2 · Cited by 304
Self-citationVentral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265
Metadata
- Authors
- Paré, W. P., & Glavin, G. B.
- Affiliations
- United States Department of Veterans Affairs (US)
- University of Manitoba (CA)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 1986-09
- Volume
- 10
- Issue
- 3
- Pages
- 339-370
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1982596294
- Cited by
- 376
- References
- 327
- Citations by year
- 2026: 8 · 2025: 1 · 2024: 11 · 2023: 18 · 2022: 14 · 2021: 11 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 6 · 2014: 11 · 2013: 11 · 2012: 15
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
- Keywords
- restraint stress, immobilization, stress response syndromes, gastric stress ulcer, stress-related disorders, animal models of stress
- MeSH terms
- Animals, Haplorhini, Cricetinae, Restraint, Physical, Stress, Physiological, Mice, Rats
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