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Cited by 376Stress Responses and CortisolNeuropeptides and Animal PhysiologyAnimal Behavior and Welfare Studies

The DOI matches its Crossref record; 321 of the 327 references it cites were found in a registry or an index.

Restraint stress in biomedical research: A review

Paré, William P., Glavin, Gary B.·1986·Neuroscience & Biobehavioral Reviews
DOI 10.1016/0149-7634(86)90017-5
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Abstract

The use of restraint or immobilization for investigations of animal physiology, pathology and pharmacology has an extensive history. The major use of this technique has been as a "stressor" for the induction of stress response syndromes in animals. Many such syndromes have been characterized from the behavioral level to the neurochemical concomitants of stress. As a consequence of this particular use of the restraint procedure, much information concerning drug effects on stress response syndromes has been obtained. Indeed, many researchers in the area of gastrointestinal drugs routinely screen their new compounds in a restraint model of gastric stress ulcer. The purpose of this review is to present for researchers, a summary of the methods for, the parameters of, and known drug effects on, restraint-induced pathology. In our experience, this technique has proven to be a very useful one for the examination of both central and peripheral mechanisms of stress-related disorders, as well as for studying drug effects upon these disorders.

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Research works printed but not linked: 25

  1. Ader, 1959, The effects of early experience on subsequent emotionality and resistance to stress, Psychol Monogr, 73, 1
  2. Arcai, 1969, Restraint induced gastric ulcer in the golden hamster, Pharmacology, 20, 73
  3. Baldwin, 1971, Effect of black pepper on restraint-induced mucosal ulcers in the rat, Gastroenterology, 60, 638
  4. Bonfils, 1959, L'ulcere experimental de constrainte du rat blanc. Analyse des principaux facteurs determinants, Arch Med Appet Dig, 48, 449
  5. Bonfils, 1959, Ulcere experimental de contrainte du rat blanc. II. Anatomopathologie des lesions gastriques et de differentes lesions viscerales. Evolution des ulcerations apres cessation du la contrainte, Rev Fr Etudes Clin Biol, 4, 888
  6. Bonta, 1961, Study of the effects of some glucocorticoids and ACTH on artificially induced gastric ulcers of the rat, Arch Int Pharmacodyn, 132, 147
  7. Brodie, 1961, The effect of restraint stress on gastric secretion in the chronic gastric fistula rat, Physiologist, 4, 14
  8. Buchel, 1967, Ulcere de contrainte chez le rat. 1. Influence, sur la frequence des ulceres, du jeune et de la temperature de l'environment associes a des immobilisations de durees variables, Arch Sci Physiol, 21, 527
  9. Chiu, 1984, Effects of a gastric antisecretory cytoprotectant 2-methyl-8(phenylmethoxy)imidiazo[1,2-a]pyridine-3-acetonitrile(Sch 28 080) on cysteamine, reserpine, and stress ulcers, Arzneimittelforsch, 34, 83
  10. Cosen, 1971, Les ulceres gastrigues produits par l'association de medicaments ulcerogenes et du la contrainte, Biol Gastroenterol, 4, 345
  11. Cunat, 1963, The prevention of gastric ulcers through graded exposure to restraint, Dissert Abstr Int, 24, 1251
  12. Dai, 1975, The effect of metiamide on gastric secretion and stress ulceration in the rat, Eur J Pharmacol, 33, 277, 10.1016/0014-2999(75)90171-5 · DOI
  13. Doss, 1960, The protective effect of ascorbic acid on experimental ulcer protection in rats, J Egypt Vet Med Assoc, 20, 173
  14. Glavin, 1983, Effects of altered brain noradrenaline levels on acute stress pathology in rats, Pavlov J Biol Sci, 18, 109
  15. Glavin, 1983, Ascorbic acid and cold restraint ulcer in rats: Dose response relationship, Nutr Rep Int, 28, 705
  16. Mangler, 1982, The influence of magnesium deficiency on the development of gastric stress ulcers in rats, Magnesium Bull, 4, 9
  17. Messmer, 1981, Inhibition of stress reactions by magnesium, Arzneimittelforsch, 31, 389
  18. Murison, 1980, The effect of pre-shock on adrenocortical and somatic responses to subsequent restraint stress, IRCS Med Sci, 8, 888
  19. Nagase, 1979, Experimental studies on mechanism of formation in stress ulcer—mainly on activities of amines in the brains and the gastric mucosa, J Jpn Surg Soc, 80, 902
  20. Pfeiffer, 1967, The physiological effects of restricted activity in the rat: Stress effects of chronic restraint, Exp Med Surg, 25, 201
  21. Presley, 1974, The effect of chlorpromazine, atropine, morphine, and pentobarbital on induced gastric ulceration in rats, Dissert Abstr Int, 35, 1432-B
  22. Rossi, 1956, Technique nouvelle pour produire des ulcerations gastriques chez le Rat blanc: l'ulcere de contrainte, C R Soc Biol (Paris), 150, 2124
  23. Sibilly, 1973, Prevention locale de l'ulcere gastrique experimental, J Chir, 106, 521
  24. Skolnick, 1980, Susceptibility to gastric erosions in rats as influenced by the early experience of their mothers, Dissert Abstr Int, 40, 5832-P
  25. Wilson, 1969, Stress induced oral and gastric ulcer, Br J Pharmacol, 37, 543

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Metadata

Authors
Paré, W. P., & Glavin, G. B.
Affiliations
  • United States Department of Veterans Affairs (US)
  • University of Manitoba (CA)
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1986-09
Volume
10
Issue
3
Pages
339-370
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/0149-7634(86)90017-5
OpenAlex
W1982596294
Cited by
376
References
327
Citations by year
2026: 8 · 2025: 1 · 2024: 11 · 2023: 18 · 2022: 14 · 2021: 11 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 6 · 2014: 11 · 2013: 11 · 2012: 15
FWCI
5.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
Keywords
restraint stress, immobilization, stress response syndromes, gastric stress ulcer, stress-related disorders, animal models of stress
MeSH terms
Animals, Haplorhini, Cricetinae, Restraint, Physical, Stress, Physiological, Mice, Rats

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