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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

NFβA, a factor required for maximal interleukin-1β gene expression is identical to the ets family member PU.1. Evidence for structural alteration following LPS activation

Buras, Jon A., Reenstra, Wende R., Fenton, Matthew J.·1995·Molecular Immunology
DOI 10.1016/0161-5890(95)00018-a
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Abstract

We have previously identified and characterized the macrophage-, neutrophil- and B cell-specific nuclear factor beta A (NF beta A), which is involved in transcriptional regulation of the interleukin-1 beta (IL-1 beta) gene. NF beta A binds to a highly conserved sequence element located 6 bp upstream of the TATA motif within the IL-1 beta promoter and is required for maximal expression of the IL-1 beta gene. Here we show that NF beta A is identical to the previously identified ets gene family member PU.1. The NF beta A binding element shares 100% sequence identity with a novel PU.1 binding element recently found in the immunoglobulin J-chain promoter. Methylation interference DNA footprinting data demonstrated that NF beta A and PU.1 make identical protein/DNA contacts. In vitro synthesized PU.1 possesses a mobility and binding specificity identical to NF beta A as determined by electrophoretic mobility shift analysis (EMSA). Antisera directed against amino acids 39-55 of PU.1 recognizes NF beta A in a manner indistinguishable from PU.1 in EMSA 'supershift' studies. NF beta A and PU.1 also possess similar protein structure as determined by proteolytic clipping bandshift analysis. Furthermore, we show that PU.1 is able to transactivate an NF beta A-dependent promoter when co-transfected into HeLa cells which lack PU.1/NF beta A. EMSA studies using recombinant TATA binding protein (TBP) and PU.1 suggest that PU.1 may induce assembly of a distinct TBP-dependent complex on the IL-…

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Crossref · 10.1016/0161-5890(95)00018-a

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Research works printed but not linked: 27

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Metadata

Authors
Buras, J. A., Reenstra, W. R., & Fenton, M. J.
Venue
Molecular Immunology
Publisher
Elsevier BV
Published
1995-06
Volume
32
Issue
8
Pages
541-554
ISSN
0161-5890
DOI
10.1016/0161-5890(95)00018-a
Cited by
23
References
8
Language
en
Licence

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