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Cited by 113Immunotoxicology and immune responsesStress Responses and CortisolT-cell and B-cell Immunology

Stimulation of in vivo antibody production and concanavalin-A-induced mouse spleen cell mitogenesis by prolactin

Spangelo, Bryan L., Hall, Nicholas R.S., Ross, Philip C., Goldstein, Allan L.·1987·Immunopharmacology
DOI 10.1016/0162-3109(87)90004-x
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Abstract

Regulation of the immune system by neuroendocrine hormones is receiving increased attention. Prolactin, a hormone normally associated with lactation, has been shown recently to reconstitute immunosuppressed hypophysectomized rats. The present studies demonstrate that prolactin administration to normal mice results in a biphasic stimulation of antibody production to sheep red blood cells. While 100 and 200 micrograms bovine prolactin/animal stimulated antibody production, 400 micrograms had no effect. Potentiation of lectin-induced T-cell mitogenesis by prolactin was also biphasic. As the concentration of prolactin increased the incorporation of [3H]thymidine into the cells first increased and then decreased. Decreasing serum prolactin levels with the dopaminergic agonist bromocriptine resulted in a reduction of antibody titers to sheep erythrocytes and a modulation of thymic weight. These data show that prolactin can stimulate the immune system in a biphasic manner and that a reduction in the basal levels of this hormone results in an attenuated immune response.

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Crossref · 10.1016/0162-3109(87)90004-x

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  • Changes in self-reported sleep duration were also evident in the incubation phase of the illness, before symptom development.

    “changes in self-reported sleep duration were also evident in the incubation phase of the illness, before symptom development (for review, see Ref. 517).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [517]

  • Experimentally induced influenza A and B and rhinovirus-induced common colds in healthy participants led to an increase of self-reported sleep duration in the symptomatic phase of the illness.

    “experimentally induced influenza A and B and rhinovirus-induced common colds in healthy participants led to an increase of self-reported sleep duration in the symptomatic phase of the illness (517).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [517]

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Authors
Spangelo, B. L., Hall, N. R. S., Ross, P. C., & Goldstein, A. L.
Affiliations
George Washington University (US)
Corresponding author
Hall, Nicholas R.S.
ORCID
Goldstein, Allan L.
Venue
Immunopharmacology
Publisher
Elsevier BV
Published
1987-09
Volume
14
Issue
1
Pages
11-20
ISSN
0162-3109 (ISSN-L)
DOI
10.1016/0162-3109(87)90004-x
OpenAlex
W2054696207
Cited by
113
References
25
Citations by year
2025: 1 · 2023: 1 · 2022: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2013: 1 · 2012: 1
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH 00648)
  • National Cancer Institute (CA-24974)
  • National Institute of Neurological Disorders and Stroke (NS 21210)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
prolactin, antibody production, concanavalin A, T cell mitogenesis, sheep red blood cells, bromocriptine, dopamine agonists, thymidine incorporation, thymus weight, neuroendocrine-immune regulation, immunosuppression, hypophysectomy
MeSH terms
Animals, Antibody Formation, Bromocriptine, Concanavalin A, Dose-Response Relationship, Drug, Erythrocytes, Lymphocyte Activation, Male, Mice, Inbred C57BL, Prolactin, Receptors, Prolactin, Spleen, Mice

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