Cited by 51Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesCytokine Signaling Pathways and Interactions

Expression of mRNA for 55-kDa and 75-kDa tumor necrosis factor (TNF) receptors in mouse cerebrovascular endothelium: effects of interleukin-1β, Interferon-γ and TNF-α on cultured cells

Bebo, Bruce F., Linthicum, D.Scott·1995·Journal of Neuroimmunology

Abstract

The interactions between tumor necrosis factor-alpha (TNF-alpha) and its receptors have been implicated to play an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). The effects of cytokines on the steady state levels of TNF receptor (TNFr) mRNA in cerebrovascular endothelial cells (CVE) cultured from EAE-susceptible (SJL/J) and EAE-resistant (BALB/c) mice were examined. Interferon-gamma and interleukin-1 beta up-regulated the levels of both the 55-kDa and 75-kDa TNFr mRNA, while TNF-alpha had no effect. No differences were observed in cytokine-induced TNFr mRNA levels between BALB/c and SJL/J CVE that might explain differences in EAE susceptibility.

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Crossref · 10.1016/0165-5728(95)00113-5

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  • BBB endothelial cells express key cytokine receptors (IL-1R1, IL-6, TNF receptor), and binding of these receptors leads to transport or secretion of additional proinflammatory cytokines and secondary mediators (prostaglandins) that propagate inflammatory signaling into the CNS.

    “For instance, BBB endothelial cells express key cytokine receptors (IL-1R1, IL-6, TNF receptor), and binding of these receptors leads to transport or secretion of additional proinflammatory cytokines and secondary mediators (prostaglandins) that propagate inflammatory signaling into the CNS (Bebo and Linthicum, 1995;Ericsson et al, 1995;Vallieres and Rivest, 1999).”

    From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Bebo and Linthicum, 1995

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Authors
Bebo, B. F., & Linthicum, D. S.
Affiliations
Texas A&M University (US)
Corresponding author
Linthicum, D.Scott
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
1995-11
Volume
62
Issue
2
Pages
161-167
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2091405947
Cited by
51
References
42
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
TNF receptor, cerebrovascular endothelium, mRNA expression, interferon-gamma, IL-1β, TNF-α, experimental autoimmune encephalomyelitis, SJL/J mice, BALB/c mice
MeSH terms
Animals, Brain, Cells, Cultured, Endothelium, Vascular, Interferon-gamma, Interleukin-1, Mice, Inbred BALB C, Molecular Weight, RNA, Messenger, Tumor Necrosis Factor-alpha, Receptors, Tumor Necrosis Factor, Mice

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