Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

Gould, Thomas J.

doi:10.1385/mn:34:2:93

Cited by 61Memory and Neural MechanismsNicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

Open access

Gould, Thomas J.·2006·Molecular Neurobiology

DOI 10.1385/mn:34:2:93PMC PMC2716133

Open this paper in CoChat — free account

Abstract

Addiction is a complex disorder because many factors contribute to the development and maintenance of addiction. One factor is learning. For example, drug-context associations that develop during drug use could facilitate drug craving upon re-exposure to contexts previously associated with drugs. Additionally, deficits in cognitive processes associated with withdrawal could precipitate relapse in attempts to ameliorate those deficits. Because addiction and learning involve common neural areas and cell signaling cascades, addiction-related changes in processes underlying plasticity may contribute to addiction. This article examines similarities between addiction and learning at the behavioral, neural, and cellular levels, with emphasis on the neural substrates underlying the effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on hippocampus-dependent contextual learning.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1385/mn:34:2:93

Cites

168 of 168 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cigarette smoke has been shown to affect the autonomic nervous system via its influence on fear learning.
“cigarette smoke (CS) has been shown to affect the ANS via its influence on fear learning (Gould, 2006).”
From Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke (2017) · cites this paper as Gould, 2006

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757 · see citing works
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
Bechara, A. (2005) · Nature Neuroscience · doi:10.1038/nn1584 · Cited by 2,149 · cited 1× · see citing works
“Furthermore, Bechara (30) proposed that the amygdala may become hypersensitive to reward during addiction, and this overactivation of the amygdala may lead to altered regulation of ventromedial prefrontal cortical activity involved in decision making.”
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070 · see citing works
Neurobiology of Pavlovian Fear Conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,805 · see citing works
CREB AND MEMORY
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462 · see citing works
The many faces of CREB
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308 · see citing works
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217 · see citing works
The MAPK cascade is required for mammalian associative learning
Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083 · see citing works
Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005) · Nature Neuroscience · doi:10.1038/nn1583 · Cited by 1,024 · see citing works
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works
Schizophrenia, sensory gating, and nicotinic receptors
Adler, L. E., Olincy, A., Waldo, M., Harris, J. G., Griffith, J., Stevens, K., Flach, K., Nagamoto, H., Bickford, P., Leonard, S., et al. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033320 · Cited by 690 · see citing works
Molecular mechanisms of memory acquisition, consolidation and retrieval
Abel, T. G., & Lattal, K. M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00194-x · Cited by 689 · see citing works
Dramatic decreases in brain reward function during nicotine withdrawal
Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., & Markou, A. (1998) · Nature · doi:10.1038/30001 · Cited by 674 · see citing works
Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning
Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08177.2000 · Cited by 674 · see citing works
Mortality from smoking worldwide
Peto, R., Lopez, A. D., Boreham, J., Thun, M., Heath, C., & Doll, R. (1996) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011519 · Cited by 638 · see citing works
Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory
Adams, J. P., & Sweatt, J. D. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.145401 · Cited by 588 · see citing works
Declarative memory consolidation in humans: A prospective functional magnetic resonance imaging study
Takashima, A., Petersson, K. M., Rutters, F., Tendolkar, I., Jensen, O., Zwarts, M. J., McNaughton, B. L., & Fernández, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507774103 · Cited by 557 · see citing works
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Cornish, J. L., & Kalivas, P. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0006.2000 · Cited by 546 · see citing works
The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats
Fuchs, R. A., Evans, K. A., Ledford, C. C., Parker, M. P., Case, J. M., Mehta, R. H., & See, R. E. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300579 · Cited by 517 · see citing works
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
Orr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494 · see citing works
Relapse to cocaine-seeking after hippocampal theta burst stimulation
Vorel, S. R., Liu, X., Hayes, R. J., Spector, J. A., & Gardner, E. L. (2001) · Science · doi:10.1126/science.1058043 · Cited by 486 · see citing works
Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory
Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 464 · see citing works
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
Lu, L., Hope, B., Dempsey, J., Liu, S. Y., Bossert, J., & Shaham, Y. (2005) · Nature Neuroscience · doi:10.1038/nn1383 · Cited by 453 · see citing works
Symptoms of Tobacco Withdrawal: A Replication and Extension
Hughes, J. R. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810250054007 · Cited by 449 · see citing works
Addictive drugs as reinforcers: multiple partial actions on memory systems
White, N. M. (1996) · Addiction · doi:10.1046/j.1360-0443.1996.9179212.x · Cited by 436 · see citing works
Addictive and non‐addictive drugs induce distinct and specific patterns of ERK activation in mouse brain
Valjent, E., Pagès, C., Hervé, D., Girault, J., & Caboche, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03278.x · Cited by 434 · see citing works
Cue dependency of nicotine self-administration and smoking
Caggiula, A. R., Donny, E. C., White, A. R., Chaudhri, N., Booth, S., Gharib, M. A., Hoffman, A., Perkins, K. A., & Sved, A. F. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00676-1 · Cited by 425 · see citing works
Timing and Location of Nicotinic Activity Enhances or Depresses Hippocampal Synaptic Plasticity
Ji, D., Lape, R., & Dani, J. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00332-4 · Cited by 419 · see citing works
Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task
Logue, S. F., Paylor, R., & Wehner, J. M. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.1.104 · Cited by 385 · see citing works
Limbic-Striatal Memory Systems and Drug Addiction
Robbins, T. W. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4103 · Cited by 379 · see citing works
Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task.
Logue, S. F., Paylor, R. E., & Wehner, J. M. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.1.104 · Cited by 379 · see citing works
DECLARATIVE MEMORY: Insights from Cognitive Neurobiology
Eichenbaum, H. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.547 · Cited by 371 · see citing works
Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas
Wooltorton, J. R. A., Pidoplichko, V. I., Broide, R. S., & Dani, J. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03176.2003 · Cited by 363 · see citing works
Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus
Fabian‐Fine, R., Skehel, P., Errington, M. L., Davies, H. A., Sher, E., Stewart, M. G., & Fine, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07993.2001 · Cited by 361 · see citing works
Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala.
Fanselow, M. S., & Kim, J. J. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.210 · Cited by 360 · see citing works
Orbitofrontal Cortex and Human Drug Abuse: Functional Imaging
London, E. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.334 · Cited by 360 · see citing works
Common Molecular and Cellular Substrates of Addiction and Memory
Nestler, E. J. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4084 · Cited by 354 · see citing works
Nicotinic receptors in the brain. Links between molecular biology and behavior
Picciotto, M. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00146-3 · Cited by 354 · see citing works
The hippocampus and mechanisms of declarative memory
Eichenbaum, H. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00044-3 · Cited by 353 · see citing works
Motivational Influences on Cigarette Smoking
Baker, T. B., Brandon, T. H., & Chassin, L. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142054 · Cited by 352 · see citing works
A Necessity for MAP Kinase Activation in Mammalian Spatial Learning
Selcher, J. C., Atkins, C. M., Trzaskos, J. M., Paylor, R., & Sweatt, J. D. (1999) · Learning & Memory · doi:10.1101/lm.6.5.478 · Cited by 341 · see citing works
Rodent model of nicotine abstinence syndrome
Malin, D. H., Lake, J. R., Newlin-Maultsby, P., Roberts, L. K., Lanier, J. G., Carter, V. A., Cunningham, J. S., & Wilson, O. B. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90408-8 · Cited by 334 · see citing works
Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
Fenster, C. P., Rains, M. F., Noerager, B., Quick, M. W., & Lester, R. A. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05747.1997 · Cited by 332 · see citing works
Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons
Frazier, C. J., Buhler, A. V., Weiner, J. L., & Dunwiddie, T. V. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08228.1998 · Cited by 329 · see citing works
Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior
Self, D. W., Genova, L. M., Hope, B. T., Barnhart, W. J., Spencer, J. J., & Nestler, E. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01848.1998 · Cited by 325 · see citing works
Signaling from cAMP/PKA to MAPK and Synaptic Plasticity
Waltereit, R., & Weller, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:99 · Cited by 300 · see citing works
α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of <i>Acra7</i>-Deficient Mice
Paylor, R., Nguyen, M., Crawley, J. N., Patrick, J., Beaudet, A., & Orr-Urtreger, A. (1998) · Learning & Memory · doi:10.1101/lm.5.4.302 · Cited by 298 · see citing works
N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.
Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 295 · see citing works
Nicotinic receptor function: new perspectives from knockout mice
Cordero‐Erausquin, M., Marubio, L. M., Klink, R., & Changeux, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01489-9 · Cited by 295 · see citing works
Nicotine delivery kinetics and abuse liability.
Henningfield, J. E., & Keenan, R. M. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.5.743 · Cited by 292 · see citing works
Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior
Ciano, P. D. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00235-4 · Cited by 287 · see citing works
In Vivo Regulation of [3H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs
Schwartz, R. D., & Kellar, K. J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb04005.x · Cited by 282 · see citing works
Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats
Belluzzi, J., Lee, A., Oliff, H., & Leslie, F. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1758-6 · Cited by 280 · see citing works
Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement
Chaudhri, N., Caggiula, A. R., Donny, E. C., Palmatier, M. I., Liu, X., & Sved, A. F. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0178-1 · Cited by 271 · see citing works
Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes
Papke, R. L., Sanberg, P. R., & Shytle, R. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29581-1 · Cited by 271 · see citing works
Nicotinic Stimulation Produces Multiple Forms of Increased Glutamatergic Synaptic Transmission
Radcliffe, K. A., & Dani, J. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07075.1998 · Cited by 271 · see citing works
α-Bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices
Alkondon, M., Pereira, E. F. R., & Albuquerque, E. X. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00880-4 · Cited by 263 · see citing works
Nicotine self-administration in animals and humans: similarities and differences
Rose, J. E., & Corrigall, W. A. (1997) · Psychopharmacology · doi:10.1007/s002130050209 · Cited by 262 · see citing works
Selective Excitation of Subtypes of Neocortical Interneurons by Nicotinic Receptors
Porter, J. T., Cauli, B., Tsuzuki, K., Lambolez, B., Rossier, J., & Audinat, E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05228.1999 · Cited by 262 · see citing works
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca 2+ -binding sites
Novère, N. G. L., Grütter, T., & Changeux, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042699699 · Cited by 261 · see citing works
Neural substrates of conditioned-cued relapse to drug-seeking behavior
See, R. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00682-7 · Cited by 257 · see citing works
Nicotine-induced conditioned place preference in adolescent and adult rats
Vastola, B. J., Douglas, L. A., Varlinskaya, E. I., & Spear, L. P. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00818-1 · Cited by 251 · see citing works
Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716)
Cohen, C., Perrault, G., Griebel, G., & Soubrié, P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300541 · Cited by 251 · see citing works
Measuring nicotinic receptors with characteristics of α4β2, α3β2 and α3β4 subtypes in rat tissues by autoradiography
Perry, D. C., Xiao, Y., Nguyen, H. N., Musachio, J. L., Dávila‐García, M. I., & Kellar, K. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00951.x · Cited by 246 · see citing works
Drug addiction as a disorder of associative learning. Role of nucleus accumbens shell/extended amygdala dopamine
DI CHIARA, G., TANDA, G., BASSAREO, V., PONTIERI, F., ACQUAS, E., FENU, S., CADONI, C., & CARBONI, E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09283.x · Cited by 242 · see citing works
Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task
Grottick, A. J., & Higgins, G. A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00305-3 · Cited by 240 · see citing works
The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence
Balfour, D. J. K., Wright, A. E., Benwell, M. E. M., & Birrell, C. E. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00202-3 · Cited by 231 · see citing works
Nicotine induces conditioned place preferences over a large range of doses in rats
Foll, B. L., & Goldberg, S. R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2021-5 · Cited by 229 · see citing works
Environmental stimuli promote the acquisition of nicotine self-administration in rats
Caggiula, A. R., Donny, E. C., White, A., Chaudhri, N., Booth, S., Gharib, M. A., Hoffman, A., Perkins, K. A., & Sved, A. F. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1156-5 · Cited by 225 · see citing works
Characterization of spontaneous and precipitated nicotine withdrawal in the mouse
Damaj, M. I., Kao, W., & Martin, B. R. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054908 · Cited by 222 · see citing works
The α7 nicotinic acetylcholine receptor in neuronal plasticity
Broide, R. S., & Leslie, F. M. (1999) · Molecular Neurobiology · doi:10.1007/bf02741361 · Cited by 210 · see citing works
Nicotinic Modulation of Glutamate and GABA Synaptic Transmission in Hippocampal Neurons
RADCLIFFE, K. A., FISHER, J. L., GRAY, R., & DANI, J. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11332.x · Cited by 205 · see citing works
Nicotinic α7 receptors: Synaptic options and downstream signaling in neurons
Berg, D. K., & Conroy, W. G. (2002) · Journal of Neurobiology · doi:10.1002/neu.10116 · Cited by 198 · see citing works
Nicotine activates the extracellular signal‐regulated kinase 1/2 via the α7 nicotinic acetylcholine receptor and protein kinase A, in SH‐SY5Y cells and hippocampal neurones
Dajas‐Bailador, F., Soliakov, L. S., & Wonnacott, S. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00725.x · Cited by 196 · see citing works
Fast Synaptic Signaling by Nicotinic Acetylcholine and Serotonin 5-HT3Receptors in Developing Visual Cortex
Roerig, B., Nelson, D. A., & Katz, L. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08353.1997 · Cited by 192 · see citing works
Chronic Nicotine Treatment Up-Regulates α3 and α7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y
Peng, X.-D., Gerzanich, V., Anand, R., Wang, F., & Lindstrom, J. M. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.5.776 · Cited by 191 · see citing works
Downregulation of nicotinic receptor function after chronic nicotine infusion.
Marks, M. J., Grady, S. R., & Collins, A. C. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39368-7 · Cited by 190 · see citing works
Synaptic Currents Generated by Neuronal Acetylcholine Receptors Sensitive to α-Bungarotoxin
Zhang, Z., Coggan, J. S., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80253-6 · Cited by 184 · see citing works
Importance of nonpharmacological factors in nicotine self-administration
Caggiula, A. R., Donny, E. C., Chaudhri, N., Perkins, K. A., Evans-Martin, F. F., & Sved, A. F. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00918-6 · Cited by 180 · see citing works
<i>In vivo</i> nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice
Brunzell, D. H., Russell, D. S., & Picciotto, M. R. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01640.x · Cited by 176 · see citing works
Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats
Chaudhri, N., Caggiula, A. R., Donny, E. C., Booth, S., Gharib, M. A., Craven, L. A., Allen, S. S., Sved, A. F., & Perkins, K. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2152-3 · Cited by 176 · see citing works
5-Iodo-A-85380, an α4β2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors
Mukhin, A. G., Gündisch, D., Horti, A. G., Koren, A. O., Tamagnan, G., Kimes, A. S., Chambers, J., Vaupel, D. B., King, S. L., Picciotto, M. R., et al. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.3.642 · Cited by 173 · see citing works
Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes.
Olale, F., Gerzanich, V., Kuryatov, A., Wang, F., & Lindstrom, J. M. (1997) · PubMed · Cited by 172 · see citing works
Ultrastructural localization of GLUT 1 and GLUT 3 glucose transporters in rat brain
Leino, R. L., Gerhart, D. Z., Bueren, A. M. V., McCall, A. L., & Drewes, L. R. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970901)49:5 · Cited by 164 · see citing works
Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH‐SY5Y cells: contribution of voltage‐operated Ca2+ channels and Ca2+ stores
Dajas‐Bailador, F., Mogg, A. J., & Wonnacott, S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00846.x · Cited by 158 · see citing works
Voltage-Gated Channels Block Nicotinic Regulation of CREB Phosphorylation and Gene Expression in Neurons
Chang, K. T., & Berg, D. K. (2001) · Neuron · doi:10.1016/s0896-6273(01)00516-5 · Cited by 157 · see citing works
Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
Widnell, K. L., Self, D. W., Lane, S. B., Russell, D., Vaidya, V. A., Miserendino, M. J. D., Rubin, C. S., Duman, R. S., & Nestler, E. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12267-2 · Cited by 156 · see citing works
Neurotrophin-3 Contributes to the Initiation of Behavioral Sensitization to Cocaine by Activating the Ras/Mitogen-Activated Protein Kinase Signal Transduction Cascade
Pierce, R. C., Pierce-Bancroft, A. F., & Prasad, B. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08685.1999 · Cited by 153 · see citing works
Nicotine self-administration in animals as a dependence model
Corrigall, W. A. (1999) · Nicotine & Tobacco Research · doi:10.1080/14622299050011121 · Cited by 153 · see citing works
Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices
Hefft, S., Hulo, S., Bertrand, D., & Müller, D. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.769ab.x · Cited by 152 · see citing works
Nicotine enhancement of contextual fear conditioning
Gould, T. J., & Wehner, J. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00157-0 · Cited by 151 · see citing works
Withdrawal from Chronic Nicotine Administration Impairs Contextual Fear Conditioning in C57BL/6 Mice
Davis, J. A., James, J. R., Siegel, S. J., & Gould, T. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2853-05.2005 · Cited by 146 · see citing works
Self-citation
Nicotine-induced conditioned place preference and conditioned place aversion in mice
Risinger, F. O., & Oakes, R. A. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00007-j · Cited by 142 · see citing works
Differential effects of the N-methyl-d-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues
Fanselow, M. S., Kim, J. J., Yipp, J., & De Oca, B. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.2.235 · Cited by 142 · see citing works
Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues.
Fanselow, M. S., Kim, J. J., Yipp, J., & De, B. M. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.2.235 · Cited by 141 · see citing works
Genetics of nicotine response in four inbred strains of mice
Marks, M. J., Burch, J. B., & Collins, A. C. (1983) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21452-5 · Cited by 140 · cited 1× · see citing works
“The increases in nAChR binding sites may be a compensatory mechanism induced by nAChR desensitization (158,162).”
Nicotine‐induced phosphorylation of extracellular signal‐regulated protein kinase and CREB in PC12h cells
Nakayama, H., Numakawa, T., Ikeuchi, T., & Hatanaka, H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00602.x · Cited by 139 · see citing works
ERK regulation in chronic ethanol exposure and withdrawal
Sanna, P. P., Simpson, C., Lütjens, R., & Koob, G. F. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03191-8 · Cited by 134 · see citing works
Calcium-Mediated Second Messengers Modulate the Expression of Behavioral Sensitization to Cocaine
Pierce, R. C., Quick, E., Reeder, D., Morgan, Z. R., & Kalivas, P. W. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37708-0 · Cited by 133 · see citing works
A role for the prefrontal cortex in recall of recent and remote memories
Blum, S., Hebert, A. E., & Dash, P. (2006) · NeuroReport · doi:10.1097/01.wnr.0000201509.53750.bc · Cited by 127 · see citing works
Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training
Gould, T. J., & Stephen Higgins, J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00057-1 · Cited by 123 · see citing works
Self-citation
Nicotine place preference in the mouse: influences of prior handling, dose and strain and attenuation by nicotinic receptor antagonists
Grabus, S. D., Martin, B. R., Brown, S. E., & Damaj, M. I. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0305-7 · Cited by 118 · see citing works
Role of α7 nicotinic receptors in nicotine dependence and implications for psychiatric illness
Nomikos, G. G., Schilström, B., Hildebrand, B. E., Panagis, G., Grenhoff, J., & Svensson, T. H. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00204-7 · Cited by 115 · see citing works
Effects of nicotine administration following 12 h of tobacco deprivation: assessment on computerized performance tasks
Snyder, F. R., & Henningfield, J. E. (1989) · Psychopharmacology · doi:10.1007/bf00443406 · Cited by 112 · see citing works
Smoking after nicotine deprivation enhances cognitive performance and decreases tobacco craving in drug abusers
Bell, S., Taylor, R., Singleton, E., Henningfield, J., & Heishman, S. (1999) · Nicotine & Tobacco Research · doi:10.1080/14622299050011141 · Cited by 107 · see citing works
Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat
Sorenson, E. M., Shiroyama, T., & Kitai, S. T. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00064-5 · Cited by 107 · see citing works
Inactivation of α7 ACh receptors and activation of non-α7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region
Fujii, S., Ji, Z., & Sumikawa, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01076-4 · Cited by 106 · see citing works
Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning
Wehner, J. M., Keller, J. J., Keller, A. B., Picciotto, M. R., Paylor, R. E., Booker, T. K., Beaudet, A. L., Heinemann, S., & Balogh, S. A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.016 · Cited by 105 · see citing works
Impairment of conditioned contextual fear of C57BL/6J mice by intracerebral injections of the NMDA receptor antagonist APV
Stiedl, O., Birkenfeld, K., Palve, M., & Spiess, J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00269-2 · Cited by 103 · see citing works
Smoking patterns and abstinence effects in smokers with no ADHD, childhood ADHD, and adult ADHD symptomatology
Pomerleau, C. S., Downey, K. K., Snedecor, S. M., Mehringer, A. M., Marks, J. L., & Pomerleau, O. F. (2002) · Addictive Behaviors · doi:10.1016/s0306-4603(02)00223-x · Cited by 100 · see citing works
Region-specific transcriptional response to chronic nicotine in rat brain
Konu, Ö., Kane, J. K., Barrett, T., Vawter, M. P., Chang, R., Ma, J. Z., Donovan, D. M., Sharp, B. M., Becker, K. G., & Li, M. D. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02685-3 · Cited by 98 · see citing works
Chapter 27 Nicotine dependence and tolerance in man: pharmacokinetic and pharmacodynamic investigations
Benowitz, N. L., Porchet, H. C., & Jacob, P. (1989) · Progress in brain research · doi:10.1016/s0079-6123(08)62487-5 · Cited by 98 · see citing works
Allosteric nicotinic receptors, human pathologies
Léna, C., & Changeux, J. (1998) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(98)80140-x · Cited by 93 · see citing works
Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region
Fujii, S., Jia, Y., Yang, A., & Sumikawa, K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02119-3 · Cited by 93 · see citing works
Nicotinic receptor‐mediated regulation of dopamine transporter activity in rat prefrontal cortex
Drew, A. E., Derbez, A. E., & Werling, L. L. (2000) · Synapse · doi:10.1002/1098-2396(200010)38:1 · Cited by 93 · see citing works
Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze
Levin, E. D., & Rose, J. E. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90293-s · Cited by 91 · see citing works
Review: Protein Kinase Signal Transduction Cascades in Mammalian Associative Conditioning
Selcher, J. C., Weeber, E. J., Varga, A. W., Sweatt, J. D., & Swank, M. W. (2002) · The Neuroscientist · doi:10.1177/107385840200800208 · Cited by 90 · see citing works
α7 Nicotinic Acetylcholine Receptors Occur at Postsynaptic Densities of AMPA Receptor-Positive and -Negative Excitatory Synapses in Rat Sensory Cortex
Levy, R. B., & Aoki, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05001.2002 · Cited by 88 · see citing works
Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex
Kumari, V., & Gray, J. A. (1999) · Psychopharmacology · doi:10.1007/s002130050800 · Cited by 88 · see citing works
Microarray analysis of nicotine-induced changes in gene expression in endothelial cells
Zhang, S., Day, I. N. M., & Ye, S. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.5.4.187 · Cited by 88 · see citing works
Applying genetic approaches to the treatment of nicotine dependence
Lerman, C. E., & NIAURA, R. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205801 · Cited by 83 · see citing works
Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment
Marks, M. J., Rowell, P. P., Cao, J., Grady, S. R., McCallum, S. E., & Collins, A. C. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.02.009 · Cited by 81 · see citing works
Nicotine Enhances Contextual Fear Conditioning and Ameliorates Ethanol-Induced Deficits in Contextual Fear Conditioning.
Gould, T. J., & Lommock, J. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1276 · Cited by 79 · see citing works
The effects of DHBE and MLA on nicotine-induced enhancement of contextual fear conditioning in C57BL/6 mice
Davis, J. A., & Gould, T. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0047-y · Cited by 78 · see citing works
Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice
Gould, T. J., Feiro, O., & Moore, D. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.009 · Cited by 78 · see citing works
Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain
Pandey, S. C., Roy, A., Xu, T., & Mittal, N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00309.x · Cited by 75 · see citing works
Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain
Caldarone, B. J., Duman, C. H., & Picciotto, M. R. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00137-4 · Cited by 75 · see citing works
Characterization of the recombinant human neuronal nicotinic acetylcholine receptors α3β2 and α4β2 stably expressed in HEK293 cells
Chavez-Noriega, L. E., Gillespie, A. J., Stauderman, K. A., Crona, J. H., Claeps, B. O., Elliott, K. J., Reid, R. T., Rao, T. S., Veliçelebi, G., Harpold, M. M., et al. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00134-9 · Cited by 73 · see citing works
Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation
McCallum, S. E., Collins, A. C., Paylor, R. E., & Marks, M. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0076-6 · Cited by 72 · see citing works
Role of amygdala oscillations in the consolidation of emotional memories
Pelletier, J. G., & Paré, D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.019 · Cited by 71 · see citing works
Functional Deactivation of the Major Neuronal Nicotinic Receptor Caused by Nicotine and a Protein Kinase C-Dependent Mechanism
Eilers, H., Schaeffer, E., Bickler, P. E., & Forsayeth, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.6.1105 · Cited by 71 · see citing works
Participation of CaMKII in Neuronal Plasticity and Memory Formation
Cammarota, M., Bevilaqua, L. R., Viola, H., Kerr, D. S., Reichmann, B. P., Teixeira, V., Bulla, M. C., Izquierdo, I., & Medina, J. H. (2002) · Cellular and Molecular Neurobiology · doi:10.1023/a:1020763716886 · Cited by 65 · see citing works
Nicotine recruits a local glutamatergic circuit to excite septohippocampal GABAergic neurons
Wu, M., Hajszán, T., Léránth, C., & Alreja, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02847.x · Cited by 62 · see citing works
Nicotine addiction: insights from recent animal studies
Mathieu-Kia, A.-M., Kellogg, S. H., Butelman, E. R., & Kreek, M. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1096-0 · Cited by 62 · see citing works
Nicotinic receptors on hippocampal cultures can increase synaptic glutamate currents while decreasing the NMDA-receptor component
Fisher, J. L., & Dani, J. A. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00102-7 · Cited by 61 · see citing works
Nicotine accelerates reversal of long-term potentiation and enhances long-term depression in the rat hippocampal CA1 region
Fujii, S., & Sumikawa, K. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02058-3 · Cited by 59 · see citing works
MK-801 disrupts acquisition of contextual fear conditioning but enhances memory consolidation of cued fear conditioning
Gould, T. J., McCarthy, M. M., & Keith, R. A. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200207000-00005 · Cited by 59 · see citing works
Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus
Fujii, S., & Sumikawa, K. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02057-1 · Cited by 58 · see citing works
Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels
Barrantes, G. E., MURPHY, C. T., Westwick, J. K., & Wonnacott, S. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11859-u · Cited by 55 · see citing works
Neuronal MEK is important for normal fear conditioning in mice
Shalin, S. C., Zirrgiebel, U., Honsa, K. J., Julien, J., Miller, F. D., Kaplan, D. R., & Sweatt, J. D. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20052 · Cited by 54 · see citing works
Functional characterization of mouse α4β2 nicotinic acetylcholine receptors stably expressed in HEK293T cells
Karadsheh, M. S., Shah, M. S., Tang, X., Macdonald, R. L., & Stitzel, J. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02801.x · Cited by 51 · see citing works
Persistent changes in motivation to self‐administer cocaine following modulation of cyclic AMP‐dependent protein kinase A (PKA) activity in the nucleus accumbens
Lynch, W. J., & Taylor, J. R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04305.x · Cited by 51 · see citing works
NMDA and AMPA Receptors Contribute to the Nicotinic Cholinergic Excitation of CA1 Interneurons in the Rat Hippocampus
Alkondon, M., Pereira, E. F. R., & Albuquerque, E. X. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00214.2003 · Cited by 50 · see citing works
Effects of Prolonged Nicotinic Ligand Exposure on Function of Heterologously Expressed, Human α4β2- and α4β4-Nicotinic Acetylcholine Receptors
Gentry, C. L., Wilkins, L. H., & Lukas, R. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041756 · Cited by 47 · see citing works
The nicotinic α4β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices
Chen, Y., Sharples, T. J. W., Phillips, K. G., Benedetti, G., Broad, L. M., Zwart, R., & Sher, E. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00189-8 · Cited by 45 · see citing works
Nicotine produces a within-subject enhancement of contextual fear conditioning in C57BL/6 mice independent of sex
Gould, T. J. (2003) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02688830 · Cited by 44 · see citing works
Nicotine withdrawal syndrome: behavioural distress and selective up‐regulation of the cyclic AMP pathway in the amygdala
Tzavara, E. T., Monory, K., Hanoune, J., & Nomikos, G. G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02061.x · Cited by 40 · see citing works
Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortex
Chu, Z., Zhou, F., & Hablitz, J. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03076-6 · Cited by 40 · see citing works
First and Second Transmembrane Segments of α3, α4, β2, and β4 Nicotinic Acetylcholine Receptor Subunits Influence the Efficacy and Potency of Nicotine
Rush, R., Kuryatov, A., Nelson, M. E., & Lindstrom, J. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.6.1416 · Cited by 40 · see citing works
Modulation of CREB expression and phosphorylation in the rat nucleus accumbens during nicotine exposure and withdrawal
Pluzarev, O., & Pandey, S. C. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20216 · Cited by 39 · see citing works
Involvement of α7- and α4β2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons
Matsubayashi, H., Inoue, A., Amano, T., Seki, T., Nakata, Y., Sasa, M., & Sakai, N. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.06.040 · Cited by 37 · see citing works
Mild anxiogenic effects of nicotine withdrawal in mice
Jonkman, S., Henry, B., Semenova, S., & Markou, A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.04.032 · Cited by 35 · see citing works
Repetitive exposures to nicotine induce a hyper‐responsiveness via the cAMP/PKA/CREB signal pathway in Drosophila
Hou, J., Kuromi, H., Fukasawa, Y., Ueno, K., Sakai, T., & Kidokoro, Y. (2004) · Journal of Neurobiology · doi:10.1002/neu.20021 · Cited by 35 · see citing works
Effects of Cigarette Smoking and Smoking Deprivation on Paired-Associate Learning of High and Low Meaningful Nonsense Syllables
Kleinman, K. M., Vaughn, R., & CHRIST, T. S. (1973) · Psychological Reports · doi:10.1177/003329417303200366.1 · Cited by 34 · see citing works
Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration
Semenova, S., Bespalov, A., & Markou, A. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01904-6 · Cited by 34 · see citing works
The interactive effects of nicotinic and muscarinic cholinergic receptor inhibition on fear conditioning in young and aged C57BL/6 mice
Feiro, O., & Gould, T. J. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.11.005 · Cited by 34 · see citing works
Memory formation requires p38MAPK activity in the rat hippocampus
Alonso, M., Bevilaqua, L. R., Izquierdo, I., Medina, J. H., & Cammarota, M. (2003) · Neuroreport · doi:10.1097/00001756-200310270-00022 · Cited by 34 · see citing works
Tobacco smoking increases gating of irrelevant and enhances attention to relevant tones
Domino, E. F., & Kishimoto, T. (2002) · Nicotine & Tobacco Research · doi:10.1080/14622200110098400 · Cited by 33 · see citing works
Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioningPreprint
Gould, T. J., & Lewis, M. C. (2005) · Learning & Memory · doi:10.1101/lm.89105 · Cited by 33 · see citing works
Enhanced reward-related responding following cholera toxin infusion into the nucleus accumbens
Kelley, A. E., & Holahan, M. R. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199705)26:1 · Cited by 31 · see citing works
Startle response during smoking and 24 h after withdrawal predicts successful smoking cessation
Postma, P., Kumari, V., Sharma, T., Hines, M., & Gray, J. A. (2001) · Psychopharmacology · doi:10.1007/s002130100829 · Cited by 26 · see citing works
Postsynaptic α4β2 and α7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons
Matsubayashi, H., Amano, T., Seki, T., Sasa, M., & Sakai, N. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.040 · Cited by 21 · see citing works
Nicotinic acetylcholine receptors in primary cultures of hippocampal neurons: pharmacology and Ca++ permeability
Barrantes, G. E., Westwick, J. K., & Wonnacott, S. (1994) · Biochemical Society Transactions · doi:10.1042/bst022294s · Cited by 18 · see citing works
Effects of Short‐ and Long‐Term Nicotine Treatment on Intracellular Calcium and Tyrosine Hydroxylase Gene Expression
Sabban, E. L., & Gueorguiev, V. D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04430.x · Cited by 11 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

[80]Rossebo OE, Gould TJ. Nicotine enhancement of cued trace fear conditioning but not cued delay fear conditioning in C57BL/6J mice. Soc. Neurosci. Abs. 2003;89:1. [Google Scholar]
[134]Broide RS, Leslie FM. The alpha7 nicotinic acetylcholine receptor in neuronal plasticity. Mol. Neurobiol. 1999;20:1–16. doi: 10.1007/BF02741361. [DOI] [PubMed] [Google Scholar] · DOI

Sorted by citations

Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li, C.-S. R., & Sinha, R. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.003 · Cited by 345 · see citing works
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?: Figure 1.
Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G., & Overstreet‐Wadiche, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3798-08.2008 · Cited by 247 · see citing works
Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242 · see citing works
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses
Miwa, J. M., Freedman, R., & Lester, H. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.014 · Cited by 205 · see citing works
Tobacco addiction and the dysregulation of brain stress systems
Bruijnzeel, A. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.015 · Cited by 172 · see citing works
The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction
López‐Moreno, J. A., González‐Cuevas, G., Moreno, G., & Navarro, M. A. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00105.x · Cited by 131 · see citing works
Hippocampal α4β2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning
Davis, J. A., Kenney, J. W., & Gould, T. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3242-07.2007 · Cited by 107 · see citing works
Self-citation
Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction
Olive, M. F. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.01.029 · Cited by 80 · see citing works
β2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
Davis, J. A., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0624-8 · Cited by 72 · see citing works
“These nAChR subtypes are critically involved in some hippocampus-dependent tasks (Barros et al. 2004; Curzon et al. 1996; Felix and Levin 1997; Levin et al. 2002) and have a modulatory role in other hippocampus-dependent tasks (Davis and Gould 2006; Wehner et al. 2004).”
BackgroundMethodResultInfluentialSelf-citation
Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research
Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.006 · Cited by 71 · see citing works
Hippocampal Long-Term Potentiation Is Disrupted during Expression and Extinction But Is Restored after Reinstatement of Morphine Place Preference
Portugal, G. S., Al‐Hasani, R., Fakira, A. K., González-Romero, J. L., Melyan, Z., McCall, J. G., Bruchas, M. R., & Morón, J. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2838-13.2014 · Cited by 70 · see citing works
β2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
Portugal, G. S., Kenney, J. W., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.002 · Cited by 66 · see citing works
Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice.
Raybuck, J. D., Portugal, G. S., Lerman, C., & Gould, T. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012601 · Cited by 62 · see citing works
Self-citation
Age-associated changes in nicotine dependence
Park, S., Lee, J.-Y., Song, T. M., & Cho, S. (2012) · Public Health · doi:10.1016/j.puhe.2012.02.007 · Cited by 62 · see citing works
“Interestingly, a significant decrease in high-affinity nicotinic binding in the hippocampus, a brain region involved in addiction, has been shown to occur around 40 years of age.(26,27) Reduced nicotinic binding affinity has been shown in patients with neurodegenerative diseases and in aged individuals.”
Background
Substance abuse, memory, and post-traumatic stress disorder
Tipps, M. E., Raybuck, J. D., & Lattal, K. M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.002 · Cited by 62 · see citing works
“This effect has been replicated across many studies and suggests that chronic exposure to nicotine produces tolerance to its enhancing effects on learning and memory (Gould, 2006).”
BackgroundResult
Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits
Davis, J. A., & Gould, T. J. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.003 · Cited by 60 · see citing works
Self-citation
Ryanodine receptor‐2 upregulation and nicotine‐mediated plasticity
Ziviani, E., Lippi, G., Bano, D., Munarriz, E. R., Guiducci, S., Zoli, M., Young, K. W., & Nicotera, P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.279 · Cited by 59 · see citing works
“In the central nervous system, nicotine has a multitude of effects ranging from enhanced cognitive function to neuro- protection and addiction (Gotti and Clementi, 2004; Gould, 2006; Levin et al, 2006; Rose, 2007; Picciotto and Zoli, 2008).”
Background
Nicotine withdrawal‐induced deficits in trace fear conditioning in C57BL / 6 mice – a role for high‐affinity β2 subunit‐containing nicotinic acetylcholine receptors
Raybuck, J. D., & Gould, T. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06580.x · Cited by 53 · see citing works
Atomoxetine Reverses Nicotine Withdrawal-Associated Deficits in Contextual Fear Conditioning
Davis, J. A., & Gould, T. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301315 · Cited by 52 · see citing works
“The results of our research (Davis and Gould, 2006; Davis et al, 2005, 2006; Gould, 2003; Gould et al, 2004; Gould and Higgins, 2003; Gould and Lommock, 2003; Gould and Wehner, 1999) and the research of others (Wehner et al, 2004) indicate that acute nicotine dose dependently enhances contextual…”
BackgroundResult
Nicotine facilitates long‐term potentiation induction in oriens‐lacunosum moleculare cells via Ca2+ entry through non‐α7 nicotinic acetylcholine receptors
Jia, Y., Yamazaki, Y., Nakauchi, S., Ito, K., & Sumikawa, K. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07058.x · Cited by 51 · see citing works
Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis
Froeliger, B., Kozink, R. V., Rose, J. E., Behm, F. M., Salley, A. N., & McClernon, F. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1862-3 · Cited by 49 · see citing works
“Nicotine withdrawal impairs hippocampaldependent memory processes, whereas acute nicotine administration restores it, and these effects are thought to occur via nicotine’s modulation of multiple neurotransmitter systems including acetylcholine, norepinephrine, glutamate, and dopamine (Gould 2006; Levin et al. 2006).”
Background
Associative Learning, the Hippocampus, and Nicotine Addiction
Gould, T. J., & Davis, J. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010009 · Cited by 49 · see citing works
Nicotine withdrawal disrupts new contextual learning
Portugal, G. S., & Gould, T. J. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.11.001 · Cited by 43 · see citing works
“Investigations into the neurobiologyof addictionhave revealed that drugs of abuse can alter learning and memory and that many of the neural substrates disrupted by drug addiction also play an important role in learning and memory (Davis and Gould, 2008; Gould, 2006; Hyman, 2005; Kelley, 2004).”
Background
Patterns and Characteristics of Nicotine Dependence Among Adults With Cigarette Use in the US, 2006-2019
Han, B., Einstein, E. B., & Compton, W. M. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.19602 · Cited by 41 · see citing works
α2 Nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits
Jia, Y., Yamazaki, Y., Nakauchi, S., & Sumikawa, K. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06706.x · Cited by 39 · see citing works
Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6 mice
André, J. M., Gulick, D., Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.018 · Cited by 38 · see citing works
Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice
Gulick, D., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.002 · Cited by 37 · see citing works
“…diverse neuronal processes (Davis & De Fiebre, 2006) such as those involved in reward/reinforcement (Jerlhag, Grotli, Luthman, Svensson, & Engel, 2006; Walters, Brown, Changeux, Martin, & Damaj, 2006) and learning/memory (Chan, Wong, & Sheu, 2007; Davis, Kenney, & Gould, 2007; Gould, 2006).”
Nicotine and extinction of fear conditioning
Elias, G. A., Gulick, D., Wilkinson, D. S., & Gould, T. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.022 · Cited by 36 · see citing works
Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus
André, J. M., Leach, P. T., & Gould, T. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.004 · Cited by 32 · see citing works
“It is possible that nicotine ameliorates NMDAR antagonist-induced deficits in contextual fear conditioning by gating a sufficient amount of calcium to directly activate learning-related cell signaling cascades (Dajas-Bailador and Wonnacott, 2004; Gould, 2006; Tinsley et al., 2004).”
Background
Heterogeneity of Reward Mechanisms
Lajtha, Á., & Sershen, H. W. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0096-4 · Cited by 32 · see citing works
Nicotine enhances contextual fear memory reconsolidation in rats
Tian, S., Huang, F., Li, P., Zhen-bang, L. I., Zhou, S., Deng, H., & Yang, Y. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.058 · Cited by 31 · see citing works
Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits
Sey, N. Y. A., Hu, B., Iskhakova, M., Lee, S., Sun, H., Shokrian, N., Hutta, G. B., Marks, J. A., Quach, B. C., Johnson, E. O., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01558-y · Cited by 27 · see citing works
“We also found strong expression in the hippocampus for ND risk genes, highlighting the role of hippocampus-dependent learning in ND [54].”
Background
Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine
Leach, P. T., & Gould, T. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.001 · Cited by 24 · see citing works
The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice
Wilkinson, D. S., & Gould, T. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.010 · Cited by 26 · see citing works
Immediate and persisting effect of toluene chronic exposure on hippocampal cell loss in adolescent and adult rats
Zhvania, M. G., Chilachava, L., Japaridze, N. J., Gelazonia, L., & Lordkipanidze, T. G. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.021 · Cited by 20 · see citing works
Neuroactive effects of cotinine on the hippocampus: Behavioral and biochemical parameters
Aguiar, R. B., Parfitt, G. M., Jaboinski, J., & Barros, D. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.032 · Cited by 20 · see citing works
“Nicotine also stimulates changes in calcium influx and in the release of calcium internal stores, which can activate not only kinases but also transcription factors such as CREB (reviewed by Gould, 2006).”
Vulnerability to nicotine self-administration in adolescent mice correlates with age-specific expression of α4* nicotinic receptors
Renda, A., Penty, N., Komal, P., & Nashmi, R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.019 · Cited by 17 · see citing works
α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression
Upton, M. K., & Lotfipour, S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.015 · Cited by 16 · see citing works
Involvement of neuronal β 2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: Implications for pharmacotherapies
Simmons, S. J., & Gould, T. J. (2014) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12171 · Cited by 16 · see citing works
Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system
Dehkordi, O., Rose, J. E., Asadi, S., Manaye, K. F., Millis, R. M., & Jayam‐Trouth, A. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23477 · Cited by 17 · see citing works
Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning
Connor, D. A., & Gould, T. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.033 · Cited by 15 · see citing works
“In contrast, immediate abstinence (withdrawal) from chronic nicotine elicits deficits in hippocampusdependent learning in adult mice (Davis et al., 2005; Davis and Gould, 2009; Gould et al., 2012; Raybuck and Gould, 2009).”
Background
ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice
Yildirim, E., Connor, D. A., & Gould, T. J. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000111 · Cited by 13 · see citing works
Neuropeptide CART prevents memory loss attributed to withdrawal of nicotine following chronic treatment in mice
Borkar, C. D., Sagarkar, S., Sakharkar, A. J., Subhedar, N. K., & Kokare, D. M. (2017) · Addiction Biology · doi:10.1111/adb.12579 · Cited by 13 · see citing works
Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke
Payne, P., Fiering, S., Leiter, J. C., Zava, D. T., & Crane-Godreau, M. A. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00067 · Cited by 12 · see citing works
“In addition to its role as a principal cause of COPD (Moritsugu, 2007), cigarette smoke (CS) has been shown to affect the ANS via its influence on fear learning (Gould, 2006).”
Background
Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis
Alén, F., Mouret, A., Viveros, M., Llorente, R., Lepousez, G., Lledo, P., & López‐Moreno, J. A. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991118 · Cited by 11 · see citing works
Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in c57bl/6j mice.
Poole, R. L., Connor, D. A., & Gould, T. J. (2014) · Behavioral Neuroscience · doi:10.1037/bne0000003 · Cited by 11 · see citing works
“, & Gould, T. J. (2009). Nicotine withdrawal disrupts new contextual learning.”
BackgroundInfluential
Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats
Rehman, N. U., Esmaeilpour, K., Joushi, S., Abbas, M., al‐Rashida, M., Rauf, K., & Masoumi‐Ardakani, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110783 · Cited by 10 · see citing works
Cognitive mechanisms underlying relapse to nicotine
Lester, R. A. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.038 · Cited by 10 · see citing works
“…c to the hippocampus, a study of the cellular and molecular actions of nicotine in the hippocampus, particularly its plasticity inducing effects (Gould, 2006) may move the fi eld towards a neuronal explanation for the context-dependent behavioral changes, just as hippocampal synaptic long-term…”
Background
Age-dependent and pathway-specific bimodal action of nicotine on synaptic plasticity in the hippocampus of mice lacking the miR-132/212 genes
Stojanovic, T., Velarde Gamez, D., Schuld, G. J., Bormann, D., Cabatic, M., Uhrin, P., Lubec, G., & Monje, F. J. (2022) · Cells · doi:10.3390/cells11020261 · Cited by 8 · see citing works
Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice
Molas, S., Gener, T., Güell‐Bosch, J., Martı́n, M., Ballesteros‐Yáñez, I., Sanchez-Vives, M. V., & Dierssen, M. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0147-1 · Cited by 8 · see citing works
“Drugs of abuse, including nicotine, induce neuroplasticity in areas involved in cognitive function, such as the hippocampus, a neuroadaptation assumed to contribute to the development of addiction by favoring associative memories [2-6].”
Background
Single nucleotide polymorphisms rs148582811 regulates its host gene ARVCF expression to affect nicotine-associated hippocampus-dependent memory
Yang, Z., Chen, J., Han, H., Wang, Y., Shi, X., Zhang, B., Mao, Y. Q., Li, A. N., Yuan, W., Yao, J., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108335 · Cited by 6 · see citing works
Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory
Leach, P. T., Kenney, J. W., Connor, D. A., & Gould, T. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.026 · Cited by 6 · see citing works
Neural Mechanisms of Stress and Addiction
Seo, D., & Sinha, R. (2011) · Wiley eBooks · doi:10.1002/9781119998938.ch9 · Cited by 6 · see citing works
Tobacco Smoking and Brain Endogenous Opioid Release: More Than Nicotine Alone
Domino, E. F., & Hirasawa-Fujita, M. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty039 · Cited by 6 · see citing works
The Effects of Nicotine on Learning and Memory
Gould, T. J. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_11 · Cited by 5 · see citing works
Chronic Toluene Exposure and the Hippocampal Structure in Adolescent and Adult Brains
Zhvania, M. G., Japaridze, N. J., Chilachava, L., Gelazonia, L., & Pochkhidze, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800212-4.00093-5 · Cited by 5 · see citing works
Addressing altered anticipation as a transdiagnostic target through computational psychiatry
Sepúlveda, P., Aitsahalia, I., Kumar, K., Atkin, T., & Iigaya, K. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.02.014 · Cited by 3 · see citing works
The impact of adolescent stress on nicotine use and affective disorders in rodent models
Mooney‐Leber, S. M., Caruso, M. J., Gould, T. J., Cavigelli, S. A., & Kamens, H. M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15421 · Cited by 3 · see citing works
Chromatin architecture in addiction circuitry elucidates biological mechanisms underlying cigarette smoking and alcohol use traitsPreprint
Sey, N. Y. A., Hu, B., Iskhakova, M., Sun, H., Shokrian, N., Hutta, G. B., Marks, J. A., Quach, B. C., Johnson, E. O., Hancock, D. B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.18.436046 · Cited by 1 · see citing works
EFFECTS OF ADMINISTRATION OF PERINATAL BUPROPION ON THE POPULATION SPIKE AMPLITUDE IN NEONATAL RAT HIPPOCAMPAL SLICES
Heysieattalab, S., Zare, S., Pakdel, F. G., & Hashtjini, M. M. (2010) · Iranian journal of basic medical sciences. · doi:10.22038/ijbms.2010.5114
“Over years of smoking, neuroadaptations occur and long term synaptic changes redound in the learned behaviors (15, 16).”
Background
Effect of miRNA-138 Injected into the Medial Habenula on Nicotine Intake and Preference
Fitzgerald, K. (2015) · CU Scholar (University of Colorado Boulder)

Associative Learning, the Hippocampus, and Nicotine Addiction
Gould, T. J., & Davis, J. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010009 · Cited by 49 · see citing works
Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
Gould, T. J., & Leach, P. T. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.004 · Cited by 68 · see citing works
Current Drug Abuse Reviews, 2008, 1, 9-19 9 Associative Learning, the Hippocampus, and Nicotine Addiction
Davis, J. A., & Gould, T. J. (2013)
Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addictionPreprint
Kutlu, M. G., & Gould, T. J. (2016) · Learning & Memory · doi:10.1101/lm.042192.116 · Cited by 324 · see citing works
Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242 · see citing works

Authors: Gould, T. J.
Affiliations: Temple University (US)
Corresponding author: Gould, Thomas J.
ORCID: Gould, Thomas J.
Venue: Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2006
Volume: 34
Issue: 2
Pages: 93-108
ISSN: 0893-7648 (ISSN-L)
DOI: 10.1385/mn:34:2:93
PMC: PMC2716133
OpenAlex: W2093132337
Cited by: 61
References: 167
Citations by year: 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 2
FWCI: 3.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (DA017949, R01DA017949)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: nicotine, hippocampus, contextual learning, addiction, drug craving, withdrawal, relapse, neuroplasticity, chronic nicotine exposure, signal transduction
MeSH terms: Acetylcholine, Animals, Conditioning, Psychological, Hippocampus, Humans, Learning, Neuronal Plasticity, Substance Withdrawal Syndrome, Tobacco Use Disorder, Cyclic AMP Response Element-Binding Protein, MAP Kinase Signaling System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nicotine and Hippocampus-Dependent Learning: Implications for Addiction

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks