Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression

Fenu, Sandro; Spina, Liliana; Rivas, Emilia; Longoni, Rosanna; Di Chiara, Gaetano

doi:10.1007/s00213-006-0415-2

Cited by 103Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression

Fenu, Sandro, Spina, Liliana, Rivas, Emilia, Longoni, Rosanna, Di Chiara, Gaetano·2006·Psychopharmacology

DOI 10.1007/s00213-006-0415-2

Open this paper in CoChat — free account

Abstract

Rationale A large body of evidence indicates an involvement of the mesolimbic dopamine (DA) pathway innervating the ventral striatum in the motivational effects of drug abuse.Objective The goal of the study is to clarify the role of DA D1 and D2 receptors of the rat nucleus accumbens (NAc) shell and core in the motivational effects of morphine as studied by conditioned place preference (CPP).Methods The effect of the intracerebral infusion of DA antagonists specific for DA D1 (SCH 39166) and D2 receptors (L-sulpiride) was studied in a single-trial place conditioning paradigm with fixed assignment of the drug to the unpreferred compartment.Results Morphine induced significant CPP at all the doses tested (0.5, 1.0, and 2.0 mg/kg, subcutaneously). A dose of 1.0 mg/kg was selected for further studies. Intra-NAc shell infusion of SCH 39166 and L-sulpiride at doses of 25 and 50 ng/1 microl per side impaired the acquisition of CPP by morphine. No effect was observed at 12.5 ng/1 microl per side. Intra-NAc core infusion of SCH 39166 (12.5, 25, and 50 ng/1 microl per side) did not affect the acquisition of morphine-induced CPP, while L-sulpiride (12.5, 25, and 50 ng/1 microl per side) impaired CPP acquisition only at the dose of 50 ng/1 microl per side. No effect on morphine-induced CPP was observed when the DA antagonists were infused into the NAc shell or core 10 min before the test session.Conclusion These results indicate that DA D1 and D2 receptors in the NAc shell are involved in the acquisition of morphine-induced CPP.

Integrity signals

Registry

Crossref · 10.1007/s00213-006-0415-2

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Microinjections of dopaminergic antagonists into the shell, but not the core, disrupt conditioned place preference induced by systemic nicotine or morphine.
“In addition, microinjections of dopaminergic antagonists into the shell, but not the core, disrupt conditioned place preference induced by systemic nicotine or morphine”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006
Microinjections of dopamine receptor antagonists into the medial accumbens shell, but not the core, during the acquisition phase disrupt conditioned place preference induced by systemic administration of nicotine or opiates.
“Microinjections of dopamine receptor antagonists into the medial accumbens shell, but not the core, during the acquisition phase disrupt conditioned place preference induced by systemic administration of nicotine or opiates (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006
Blockade of dopamine receptors in the medial shell just before preference testing does not change conditioned place preference induced by nicotine or morphine administration, even though the same treatments during the acquisition phase disrupt the acquisition of conditioned place preference.
“The blockade of dopamine receptors in the medial shell just before preference testing does not change conditioned place preference induced by nicotine or morphine administration, even though the same treatments during the acquisition phase disrupt the acquisition of conditioned place preference (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006
SCH 23390 administration into the accumbens core does not disrupt stimulus-outcome association in conditioned place preference procedures.
“SCH 23390 administration into the accumbens core does not disrupt stimulus-outcome association in conditioned place preference procedures (Fenu et al., 2006; Spina et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Fenu et al., 2006

The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues
Tzschentke, T. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00060-4 · Cited by 1,254 · see citing works
Neuroleptics and operant behavior: The anhedonia hypothesis
Wise, R. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010372 · Cited by 1,022 · see citing works
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996 · see citing works
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935 · see citing works
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24578-5 · Cited by 916 · see citing works
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
Pontieri, F. E., Tanda, G., & Chiara, G. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12304 · Cited by 868 · see citing works
The role of dopamine in drug abuse viewed from the perspective of its role in motivation
Chiara, G. D. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01118-i · Cited by 624 · see citing works
The mesolimbic dopamine system : from motivation to action
Willner, P., & Scheel‐Krüger, J. (1991) · Wiley eBooks · Cited by 556 · see citing works
The Mesolimbic Dopamine System: From Motivation to Action
Phillipson, O. T. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90348-c · Cited by 518 · see citing works
Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis
Salamone, J. D., Cousins, M. S., & Snyder, B. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00017-6 · Cited by 514 · see citing works
Drug reinforcement studied by the use of place conditioning in rat
Mucha, R. F., van der Kooy, D., O'Shaughnessy, M., & Bucenieks, P. (1982) · Brain Research · doi:10.1016/0006-8993(82)91123-4 · Cited by 485 · see citing works
Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions
Di Chiara, G., Morelli, M., & Consolo, S. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90005-1 · Cited by 467 · see citing works
Limbic-striatal interactions in reward-related processes
Robbins, T. W., Cador, M., Taylor, J. R., & Everitt, B. J. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80025-9 · Cited by 458 · see citing works
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
Maldonado, R. J., Saiardi, A., Valverde, O., Samad, T. A., Roques, B. P., & Borrelli, E. (1997) · Nature · doi:10.1038/41567 · Cited by 431 · see citing works
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use
Chiara, G. D. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200108 · Cited by 346 · see citing works
Heroin reward is dependent on a dopaminergic substrate
Bozarth, M. A., & Wise, R. A. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90519-1 · Cited by 334 · see citing works
Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.
Dickinson, A., Smith, J. W., & Mirenowicz, J. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.3.468 · Cited by 312 · see citing works
Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system
Spyraki, C., Fibiger, H. C., & Phillips, A. G. (1983) · Psychopharmacology · doi:10.1007/bf00427827 · Cited by 308 · see citing works
Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes
Salamone, J. D. (1992) · Psychopharmacology · doi:10.1007/bf02245133 · Cited by 291 · see citing works
Apparatus bias and place conditioning with ethanol in mice
Cunningham, C. L., Ferree, N. K., & Howard, M. A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1559-y · Cited by 284 · see citing works
Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.
Shippenberg, T. S., Bals-Kubik, R., & Herz, A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38109-7 · Cited by 275 · see citing works
Role of Dopamine D1and D2Receptors in the Nucleus Accumbens in Mediating Reward
Ikemoto, S., Glazier, B. S., Murphy, J. M., & McBride, W. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08580.1997 · Cited by 257 · see citing works
Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.
Dickinson, A., Smith, J. W., & Mirenowicz, J. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.3.468 · Cited by 249 · see citing works
Segregation of Amphetamine Reward and Locomotor Stimulation between Nucleus Accumbens Medial Shell and Core
Sellings, L. H. L., & Clarke, P. B. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06295.2003 · Cited by 231 · see citing works
Nicotine induces conditioned place preferences over a large range of doses in rats
Foll, B. L., & Goldberg, S. R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2021-5 · Cited by 229 · see citing works
SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade
Acquas, E., Carboni, E., Leone, P., & Di Chiara, G. (1989) · Psychopharmacology · doi:10.1007/bf00442800 · Cited by 207 · see citing works
The use of place conditioning in studying the neuropharmacology of drug reinforcement
Huffman, D. C. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90224-4 · Cited by 192 · see citing works
Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of μ- and κ-opioid agonists
Shippenberg, T. S., & Herz, A. (1987) · Brain Research · doi:10.1016/0006-8993(87)91571-x · Cited by 190 · see citing works
Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity.
Chipkin, R. E., Iorio, L. C., Coffin, V. L., McQuade, R. D., Berger, J. G., & Barnett, A. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13263-1 · Cited by 182 · see citing works
Neuroleptics block the positive reinforcing effects of amphetamine but not of morphine as measured by place conditioning
Mackey, W. B., & van der Kooy, D. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90492-7 · Cited by 179 · see citing works
5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward
Carboni, E., Acquas, E., Leone, P., & Chiara, G. D. (1989) · Psychopharmacology · doi:10.1007/bf00442245 · Cited by 178 · see citing works
Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning
Leone, P., & Chiara, G. D. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90621-2 · Cited by 171 · see citing works
Motivational effects of opioids: influence of D-1 versus D-2 receptor antagonists
Shippenberg, T. S., & Herz, A. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90803-5 · Cited by 156 · see citing works
Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice
Manzanedo, C., Aguilar, M. A., Rodríguez‐Arias, M., & Miñarro, J. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00164-4 · Cited by 139 · see citing works
A Role for Dopamine D1 Receptors of the Nucleus Accumbens Shell in Conditioned Taste Aversion Learning
Fenu, S., Bassareo, V., & Chiara, G. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06897.2001 · Cited by 128 · see citing works
Locomotion and conditioned place preference produced by acute intravenous amphetamine: role of dopamine receptors and individual differences in amphetamine self-administration
Bardo, M. T., Valone, J. M., & Bevins, R. A. (1999) · Psychopharmacology · doi:10.1007/s002130050917 · Cited by 119 · see citing works
Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoidance learning
Smith, J. W., Fetsko, L. A., Xu, R., & Wang, Y. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00257-9 · Cited by 103 · see citing works
Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition
Spina, L., Fenu, S., Longoni, R., Rivas, E., & Di Chiara, G. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0211-4 · Cited by 102 · see citing works
Self-citation
D1 receptor blockade stereospecifically impairs the acquisition of drug-conditioned place preference and place aversion
Acquas, E., & Chiara, G. D. (1994) · Behavioural Pharmacology · doi:10.1097/00008877-199410000-00001 · Cited by 98 · see citing works
Nicotine place preference using the biased method of conditioning
Calcagnetti, D. J., & Schechter, M. (1994) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)90108-2 · Cited by 93 · see citing works
Morphine-induced place preference in the CXBK mouse: characteristics of μ opioid receptor subtypes
Suzuki, T., Funada, M., Narita, M., Misawa, M., & Nagase, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90239-j · Cited by 92 · see citing works
Repeated testing attenuates conditioned place preference with cocaine
Bardo, M. T., Neisewander, J. L., & Miller, J. S. (1986) · Psychopharmacology · doi:10.1007/bf00310636 · Cited by 84 · see citing works
Haloperidol differentially affects reinforcement and motivational processes in rats running an alley for intravenous heroin
McFarland, K., & Ettenberg, A. (1995) · Psychopharmacology · doi:10.1007/bf02246264 · Cited by 80 · see citing works
Involvement of dopamine D2 receptors of the central amygdala on the acquisition and expression of morphine-induced place preference in rat
Rezayof, A., Zarrindast, M., Sahraei, H., & Haeri-Rohani, A. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00989-9 · Cited by 78 · see citing works
Single-trial conditioned place preference using intravenous morphine
Bardo, M. T., & Neisewander, J. L. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90092-4 · Cited by 78 · see citing works
Haloperidol blocks the response-reinstating effects of food reward: A methodology for separating neuroleptic effects on reinforcement and motor processes
Horvitz, J. C., & Ettenberg, A. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90396-6 · Cited by 75 · see citing works
Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists
Shippenberg, T. S., Bals-Kubik, R., Huber, A., & Herz, A. (1991) · Psychopharmacology · doi:10.1007/bf02244205 · Cited by 74 · see citing works
Depression of Morphine-seeking Behaviour by Dopamine Inhibition
Schwartz, A. S., & Marchok, P. L. (1974) · Nature · doi:10.1038/248257a0 · Cited by 68 · see citing works
Differential effects of intra-accumbens sulpiride on cocaine-induced locomotion and conditioned place preference.
Baker, D. L., Khroyan, T. V., O'Dell, L. E., Fuchs, R. A., & Neisewander, J. L. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20979-x · Cited by 63 · see citing works
Haloperidol prevents the reinstatement of amphetamine-rewarded runway responding in rats
Ettenberg, A. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90268-m · Cited by 55 · see citing works
Conditioned incentive properties of a food-paired conditioned stimulus remain intact during dopamine receptor blockade.
Horvitz, J. C., & Ettenberg, A. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.4.536 · Cited by 52 · see citing works
Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior.
McFarland, K., & Ettenberg, A. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.3.630 · Cited by 48 · see citing works
Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior.
McFarland, K., & Ettenberg, A. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.3.630 · Cited by 45 · see citing works
Chronic exposure to morphine does not alter the neural tissues subserving its acute rewarding properties: Apparent tolerance is overshadowing.
Bechara, A., & van der Kooy, D. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.364 · Cited by 34 · see citing works
Sertindole antagonizes morphine-, cocaine-, and methamphetamine-induced place preference in the rat
Suzuki, T., & Misawa, M. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02084-v · Cited by 32 · see citing works
Haloperidol Does Not Attenuate Conditioned Place Preferences or Locomotor Activation Produced by Food- or Heroin-Predictive Discriminative Cues
McFarland, K., & Ettenberg, A. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00218-4 · Cited by 31 · see citing works
Chronic naltrexone supersensitizes the reinforcing and locomotor-activating effects of morphine
Bardo, M. T., & Neisewander, J. L. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90224-3 · Cited by 31 · see citing works
Chronic exposure to morphine does not alter the neural tissues subserving its acute rewarding properties: Apparent tolerance is overshadowing.
Bechara, A., & van der Kooy, D. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.364 · Cited by 22 · see citing works
Effects of haloperidol on cue-induced autonomic and behavioral indices of heroin reward and motivation
Ettenberg, A., & McFarland, K. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1266-0 · Cited by 20 · see citing works
Effects of β-funaltrexamine and naloxonazine on single-trial morphine-conditioned place preference and locomotor activity
Bardo, M. T., Gehrke, B. J., Shortridge, B. E., & Rauhut, A. S. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01049-3 · Cited by 17 · see citing works
Suppression of morphine-induced conditioned place preference by l-12-chloroscoulerine, a novel dopamine receptor ligand
Liu, Z.-H., Jin, W.-Q., Zhang, H. P., Chen, X.-J., & Jin, G.-Z. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00089-3 · Cited by 17 · see citing works
In vivo autoradiography of [3H]SCH 39166 in rat brain: selective displacement by D1/D5 antagonists
Duffy, R. A., Hunt, M. A. E., Wamsley, J. K., & McQuade, R. D. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00045-4 · Cited by 14 · see citing works
Dopamine and Reward
Chiara, G. D. (2002) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-06765-9_10 · Cited by 13 · see citing works

Flagged first, then by citations

Sorted by citations

Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works
Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement
Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094341 · Cited by 611 · see citing works
Reward system and addiction: what dopamine does and doesn’t do
DiChiara, G., & Bassareo, V. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.11.003 · Cited by 534 · see citing works
Genetics of dopamine receptors and drug addiction: a comprehensive review
Foll, B. L., Gallo, A., Strat, Y. L., Lü, L., & Gorwood, P. A. P. M. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283242f05 · Cited by 387 · see citing works
Differential Effects of Blockade of Dopamine D 1 -Family Receptors in Nucleus Accumbens Core or Shell on Reinstatement of Heroin Seeking Induced by Contextual and Discrete Cues
Bossert, J. M., Poles, G. C., Wihbey, K. A., Koya, E., & Shaham, Y. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3926-07.2007 · Cited by 292 · see citing works
Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research
McKendrick, G., & Graziane, N. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.582147 · Cited by 203 · see citing works
Regional specificity in the real‐time development of phasic dopamine transmission patterns during acquisition of a cue–cocaine association in rats
Aragona, B. J., Day, J. J., Roitman, M. F., Cleaveland, N. A., Wightman, R. M., & Carelli, R. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07027.x · Cited by 120 · see citing works
Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving
Theberge, F. R., Li, X., Kambhampati, S., Pickens, C. L., St. Laurent, R., Bossert, J. M., Baumann, M. H., Hutchinson, M. R., Rice, K. C., Watkins, L. R., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.019 · Cited by 119 · see citing works
Pharmacological characterization of 50-kHz ultrasonic vocalizations in rats: Comparison of the effects of different psychoactive drugs and relevance in drug-induced reward
Simola, N., Fenu, S., Costa, G., Pinna, A., Plumitallo, A., & Morelli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.03.013 · Cited by 119 · see citing works
Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery
Weele, C. M. V., Porter‐Stransky, K. A., Mabrouk, O. S., Lovic, V., Singer, B. F., Kennedy, R. T., & Aragona, B. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12709 · Cited by 109 · see citing works
Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species
Liu, Y., Aragona, B. J., Young, K. A., Dietz, D. M., Kabbaj, M., Mazei-Robison, M., Nestler, E. J., & Wang, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911998107 · Cited by 101 · see citing works
Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation
Han, X., Jing, M.-Y., Zhao, T.-Y., Wu, N., Song, R., & Li, J. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0023-3 · Cited by 93 · see citing works
Endogenous opiates and behavior: 2006
Bodnar, R. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.09.002 · Cited by 91 · see citing works
Central GLP-1 receptor activation modulates cocaine-evoked phasic dopamine signaling in the nucleus accumbens core
Fortin, S. M., & Roitman, M. F. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.019 · Cited by 88 · see citing works
Activation of dopamine D1‐like receptors in nucleus accumbens is critical for the acquisition, but not the expression, of nutrient‐conditioned flavor preferences in rats
Touzani, K., Bodnar, R. J., & Sclafani, A. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06127.x · Cited by 84 · see citing works
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores
Lenard, N. R., Daniels, D. J., Portoghese, P. S., & Roerig, S. C. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.02.040 · Cited by 82 · see citing works
Behavioral sensitization to Δ9‐tetrahydrocannabinol and cross‐sensitization with morphine: differential changes in accumbal shell and core dopamine transmission
Cadoni, C., Valentini, V., & Chiara, G. D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05503.x · Cited by 76 · see citing works
Dual Role of Medial A10 Dopamine Neurons in Affective Encoding
Liu, Z., Shin, R. S., & Ikemoto, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.4 · Cited by 73 · see citing works
Reciprocal effects of response contingent and noncontingent intravenous heroin on in vivo nucleus accumbens shell versus core dopamine in the rat: a repeated sampling microdialysis study
Lecca, D., Valentini, V., Cacciapaglia, F., Acquas, E., & Chiara, G. D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0815-y · Cited by 70 · see citing works
Opioid-Induced GABA Potentiation after Chronic Morphine Attenuates the Rewarding Effects of Opioids in the Ventral Tegmental Area
Madhavan, A., Bonci, A., & Whistler, J. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3366-10.2010 · Cited by 69 · see citing works
The shell of the nucleus accumbens has a higher dopamine response compared with the core after non-contingent intravenous ethanol administration
Howard, E. C., Schier, C. J., Wetzel, J., Duvauchelle, C. L., & Gonzales, R. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.014 · Cited by 64 · see citing works
Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens
Thompson, B. L., Oscar‐Berman, M., & Kaplan, G. B. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.015 · Cited by 59 · see citing works
Strain dependence of adolescent Cannabis influence on heroin reward and mesolimbic dopamine transmission in adult Lewis and Fischer 344 rats
Cadoni, C., Simola, N., Espa, E., Fenu, S., & Chiara, G. D. (2013) · Addiction Biology · doi:10.1111/adb.12085 · Cited by 57 · see citing works
Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease
Chen, A. P. F., Chen, L., Kim, T. A., & Xiong, Q. (2021) · Biomedicines · doi:10.3390/biomedicines9060647 · Cited by 55 · see citing works
Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice
Li, W., Gao, Y.-H., Chang, M., Peng, Y., Yao, J., Han, R.-W., & Wang, R. (2008) · Peptides · doi:10.1016/j.peptides.2008.10.004 · Cited by 53 · see citing works
Once is too much: Conditioned changes in accumbens dopamine following a single saccharin-morphine pairing.
Grigson, P. S., & Hajnal, A. S. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1234 · Cited by 52 · see citing works
Distinct Profiles of Anxiety and Dysphoria during Spontaneous Withdrawal from Acute Morphine Exposure
Rothwell, P. E., Thomas, M. J., & Gewirtz, J. C. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.56 · Cited by 52 · see citing works
Reciprocal responsiveness of nucleus accumbens shell and core dopamine to food- and drug-conditioned stimuli
Bassareo, V., Musio, P., & Chiara, G. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2072-8 · Cited by 50 · see citing works
Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior
Young, E. A., Dreumont, S. E., & Cunningham, C. L. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.05.004 · Cited by 50 · see citing works
Dopamine D1 and D3 receptor polypharmacology as a potential treatment approach for substance use disorder
Galaj, E., Ewing, S., & Ranaldi, R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.020 · Cited by 47 · see citing works
Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle
Shin, R. S., Qin, M., Liu, Z., & Ikemoto, S. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1131-x · Cited by 44 · see citing works
Differences in dopamine responsiveness to drugs of abuse in the nucleus accumbens shell and core of Lewis and Fischer 344 rats
Cadoni, C., & Chiara, G. D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04795.x · Cited by 49 · see citing works
An Anatomical Basis for Opponent Process Mechanisms of Opiate Withdrawal
Radke, A. K., Rothwell, P. E., & Gewirtz, J. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0172-11.2011 · Cited by 42 · see citing works
Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction
Cadoni, C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00013 · Cited by 41 · see citing works
Individual Differences in Nucleus Accumbens Dopamine Receptors Predict Development of Addiction-Like Behavior: A Computational Approach
Piray, P., Keramati, M., Dezfouli, A., Lucas, C., & Mokri, A. (2010) · Neural Computation · doi:10.1162/neco_a_00009 · Cited by 39 · see citing works
Neurotensin: A role in substance use disorder?
Ferraro, L., Fasiolo, L. T., Beggiato, S., Borelli, A. C., Pomierny-Chamioło, L., Frankowska, M., Antonelli, T., Tomasini, M. C., Fuxé, K., & Filip, M. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881115622240 · Cited by 39 · see citing works
The Dopamine Response in the Nucleus Accumbens Core–Shell Border Differs From That in the Core and Shell During Operant Ethanol Self‐Administration
Howard, E. C., Schier, C. J., Wetzel, J., & Gonzales, R. A. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00965.x · Cited by 39 · see citing works
Adolescence versus adulthood: differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse
Corongiu, S., Dessì, C., & Cadoni, C. (2020) · Addiction Biology · doi:10.1111/adb.12721 · Cited by 36 · see citing works
Role of Dopamine D1 Receptors and Extracellular Signal Regulated Kinase in the Motivational Properties of Acetaldehyde as Assessed by Place Preference Conditioning
Spina, L., Longoni, R., Vinci, S., Ibba, F., Peana, A. T., Muggironi, G., Spiga, S., & Acquas, E. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01129.x · Cited by 37 · see citing works
Strain differences between Lewis and Fischer 344 rats in the modulation of dopaminergic receptors after morphine self-administration and during extinction
Sánchez-Cardoso, P., Higuera‐Matas, A., Martı́n, S., Miguéns, M., Olmo, N. D., Garcı́a-Lecumberri, C., & Ambrosio, E. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.03.014 · Cited by 32 · see citing works
Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats
Gao, J., Li, Y., Zhu, N., Brimijoin, S., & Sui, N. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112466181 · Cited by 35 · see citing works
Effects of early methylphenidate exposure on morphine- and sucrose-reinforced behaviors in adult rats: Relationship to dopamine D2 receptors
Crawford, C. A., Villafranca, S. W., Cyr, M. C., Farley, C. M., Reichel, C. M., Gheorghe, S. L., Krall, C. M., & McDougall, S. A. (2007) · Brain Research · doi:10.1016/j.brainres.2006.12.079 · Cited by 34 · see citing works
Activation of adenosine A2A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation
Simola, N., Costa, G., & Morelli, M. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4130-8 · Cited by 33 · see citing works
Electroacupuncture alleviates affective pain in an inflammatory pain rat model
Zhang, Y., Meng, X., Li, A., Xin, J., Berman, B., Lao, L., Tan, M., Ren, K., & Zhang, R. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.07.002 · Cited by 33 · see citing works
Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference
Lv, X.-F., Xu, Y., Han, J., & Cui, C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.029 · Cited by 33 · see citing works
Withania somnifera prevents acquisition and expression of morphine-elicited conditioned place preference
Ruiu, S., Longoni, R., Spina, L., Orrù, A., Cottiglia, F., Collu, M., Kasture, S. B., & Acquas, E. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32835f3d15 · Cited by 31 · see citing works
Development of conditioned place preference induced by intra-accumbens infusion of amphetamine is attenuated by co-infusion of dopamine D1 and D2 receptor antagonists
Liao, R. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.01.009 · Cited by 30 · see citing works
A Leptin-Mediated Central Mechanism in Analgesia-Enhanced Opioid Reward in Rats
Lim, G., Kim, H., McCabe, M. F., Chou, C.-W., Wang, S., Chen, L. L., Marota, J. J. A., Blood, A. J., Breiter, H. C., & Mao, J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0386-14.2014 · Cited by 27 · see citing works
Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor expression in rats
Jiang, W., Xiao, J., Li, M., Deng, H., Jiang, T., Xiong, K.-Z., Chen, Y., Wang, X.-F., & Wang, Q. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173397 · Cited by 28 · see citing works
Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core
D’Cunha, T. M., Daoud, E., Rizzo, D., Bishop, A. B., Russo, M., Mourra, G., Hamel, L., Sedki, F., & Shalev, U. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.250 · Cited by 24 · see citing works
Morphine reduces the interest for natural rewards
Piccin, A., Courtand, G., & Contarino, A. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06131-7 · Cited by 27 · see citing works
Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats
Liang, J., Ma, S.-S., Li, Y.-J., Ping, X., Hu, L., & Cui, C. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0739-8 · Cited by 24 · see citing works
Acupuncture Alleviates the Affective Dimension of Pain in a Rat Model of Inflammatory Hyperalgesia
Zhang, Y., Meng, X., Li, A., Xin, J., Berman, B., Lao, L., Tan, M., Ren, K., & Zhang, R.-X. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0534-y · Cited by 22 · see citing works
A 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated with heroin dependence in Han Chinese males
Zhang, J., Yan, P., Li, Y., Cai, X., Yang, Z., Miao, X., Chen, B., Li, S., Dang, W., Jia, W., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.017 · Cited by 20 · see citing works
The neural circuits and signalling pathways of opioid use disorder
Mathis, V., Ehrlich, A. T., & Darcq, E. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00982-7 · Cited by 22 · see citing works
Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System
Driscoll, J. R., Wallace, T. L., Mansourian, K. A., Martin, W. J., & Margolis, E. B. (2020) · eNeuro · doi:10.1523/eneuro.0376-19.2020 · Cited by 19 · see citing works
Effects of docosanyl ferulate, a constituent of Withania somnifera, on ethanol- and morphine-elicited conditioned place preference and ERK phosphorylation in the accumbens shell of CD1 mice
Maccioni, R., Serra, M., Marongiu, J., Cottiglia, F., Maccioni, E., Bassareo, V., Morelli, M., Kasture, S. B., & Acquas, E. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06069-w · Cited by 17 · see citing works
Roles of hippocampal NMDA receptors and nucleus accumbens D1 receptors in the amphetamine-produced conditioned place preference in rats
Tan, S.-E. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.09.007 · Cited by 17 · see citing works
Involvement of dopaminergic receptors of the rat nucleus accumbens in decreasing the conditioned place preference induced by lateral hypothalamus stimulation
Haghparast, A., Omranifard, A., Arezoomandan, R., Ghalandari-Shamami, M., Taslimi, Z., Vafaei, A. A., & Rashidy‐Pour, A. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.062 · Cited by 17 · see citing works
Dopamine D1 receptor agonist treatment attenuates extinction of morphine conditioned place preference while increasing dendritic complexity in the nucleus accumbens core
Kobrin, K. L., Arena, D. T., Heinrichs, S. C., Nguyen, O. H., & Kaplan, G. B. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.011 · Cited by 17 · see citing works
Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice
Cynthia Marie-claire, A., Palminteri, S., Romualdi, P., & Noble, F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.03.001 · Cited by 16 · see citing works
Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks
He, X., Xiao, L., & Sui, N. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.041 · Cited by 16 · see citing works
Systemic Administration of Orexin a Loaded Liposomes Potentiates Nucleus Accumbens Shell Dopamine Release by Sucrose Feeding
Lai, F., Cucca, F., Frau, R., Corrias, F., Schlich, M., Caboni, P., Fadda, A. M., & Bassareo, V. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00640 · Cited by 15 · see citing works
Mu Opioid Receptor Mediated Analgesia and Reward
Fields, H. L. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-993-2_10 · Cited by 14 · see citing works
Acute morphine administration alters the power of local field potentials in mesolimbic pathway of freely moving rats: Involvement of dopamine receptors
Ahmadi‐Soleimani, S. M., Mohammadi-Mahdiabadi-Hasani, M.-H., Raoufy, M. R., Azizi, H., Nasehi, M., & Zarrindast, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.09.016 · Cited by 15 · see citing works
The role of the vasopressin system and dopamine D1 receptors in the effects of social housing condition on morphine reward
Bates, M. L. S., Hofford, R. S., Emery, M. A., Wellman, P. J., & Eitan, S. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.03.021 · Cited by 14 · see citing works
Valproic acid sodium inhibits the morphine-induced conditioned place preference in the central nervous system of rats
Mu, P., & Yu, L. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.017 · Cited by 13 · see citing works
The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference.
Shen, F., Wang, N., Qi, C., Li, Y., & Cui, C. (2014) · Behavioral Neuroscience · doi:10.1037/a0036964 · Cited by 13 · see citing works
Activation of δ-opioid Receptors in Anterior Cingulate Cortex Alleviates Affective Pain in Rats
Ma, Y., Qin, G.-H., Guo, X., Hao, N., Shi, Y., Li, H., Zhao, X., Li, J., Zhang, C., & Zhang, Y. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.008 · Cited by 12 · see citing works
Role of nucleus accumbens μ opioid receptors in the effects of morphine on ERK1/2 phosphorylation
Rosas, M., Porru, S., Fenu, S., Ruiu, S., Peana, A. T., Papale, A., Brambilla, R., Chiara, G. D., & Acquas, E. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4340-8 · Cited by 12 · see citing works
Inhibition of glycogen synthase kinase-3 by SB 216763 affects acquisition at lower doses than expression of amphetamine-conditioned place preference in rats
Wickens, R. H., Quartarone, S. E., & Beninger, R. J. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000283 · Cited by 12 · see citing works
Behavioral and Neurochemical Pharmacology of 5-HT6 Receptors Related to Reward and Reinforcement
Chiara, G. D., Valentini, V., & Fenu, S. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-385902-0.00005-x · Cited by 11 · see citing works
Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm
Runegaard, A. H., Jensen, K. L., Dencker, D., Wörtwein, G., & Gether, U. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.07.010 · Cited by 11 · see citing works
Effects of CCK-8 on the reinstatement of morphine-induced CPP and expression of behavioral sensitization in rats
Wen, D., Zang, G. Y., Sun, D., Yang, S., Yu, F., Li, S., Ma, C., & Cong, B. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.057 · Cited by 9 · see citing works
Effects of morphine on place conditioning and ERK1/2 phosphorylation in the nucleus accumbens of psychogenetically selected Roman low- and high-avoidance rats
Rosas, M., Porru, S., Sabariego, M., Piludu, M. A., Giorgi, O., Corda, M. G., & Acquas, E. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4740-4 · Cited by 9 · see citing works
Sexually experienced, but not naïve, female rats show a conditioned object preference (COP) for mating after a single training trial
Piergies, A. M. H., Hicks, M. E., Schwartz, J. P., & Meerts, S. H. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.09.017 · Cited by 9 · see citing works
Conditioned saccharin avoidance and sensitization to drugs of abuse
Fenu, S., Cadoni, C., & Chiara, G. D. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.044 · Cited by 7 · see citing works
Recruitment of specific dopamine neuron sub-circuits by opioids
Morison, S. L., Doster, L. B., Vigotsky, A. D., Centeno, M. V., del Rey, N. L., Apkarian, A. V., & Awatramani, R. B. (2025) · Addiction Neuroscience · doi:10.1016/j.addicn.2025.100233 · Cited by 7 · see citing works
Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?
Robinson, T. E., & Berridge, K. C. (2026) · Psychopharmacology · doi:10.1007/s00213-025-07001-8 · Cited by 4 · see citing works
Morphine-induced place preference affects mRNA expression of G protein α subunits in rat brain
Zelek-Molik, A., Bielawski, A., Kreiner, G., Popik, P., Vetulani, J., & Nalepa, I. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70850-2 · Cited by 6 · see citing works
Involvements of stress hormones in the restraint-induced conditioned place preference
Mei, Y.-Y., & Li, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.008 · Cited by 6 · see citing works
Interactions of pain and opioids on conditioned place preference in rodents
Barattini, A. E., & Pahng, A. R. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06719-1 · Cited by 5 · see citing works
Intra‐nucleus‐accumbens SKF38393 improved the impaired acquisition of morphine‐conditioned place preference in depression‐like rats
Gao, J., Zhu, N., Feng, M., Meng, X., & Sui, N. (2012) · PsyCh Journal · doi:10.1002/pchj.9 · Cited by 5 · see citing works
In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats
Kreisler, A. D., Terranova, M. J., Somkuwar, S. S., Purohit, D. C., Wang, S., Head, B. P., & Mandyam, C. D. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02059-w · Cited by 5 · see citing works
Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposurePreprint
Gooding, S. W., Lewis, E., Chau, C., Sandhu, S., Glienke, J., & Whistler, J. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.28.601282 · Cited by 5 · see citing works
Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice
Wang, S., Li, M., Su, L., Wang, Y., Ma, D., Wang, H., Zhu, J., & Chen, T. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.893190 · Cited by 4 · see citing works
Differential effects of amphetamine on ultrasonic vocalizations and locomotor activity in a rat model of endogenous depression
Banjac, A., Elersič, K., Živin, M., & Zorović, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-27298-x · Cited by 2 · see citing works
Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats
Zhu, S., Chen, P., Chen, M., Ruan, J., Ren, W., Zhang, X., Gao, Y., & Li, Y. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05433-7 · Cited by 2 · see citing works
The role of mesolimbic circuitry in aversive signaling and opioid dependence
Branco, P., Cox, J., Wu, Y., Morison, S. L., Parker, J. G., Lerner, T. N., Martina, M., Awatramani, R. B., Surmeier, D. J., & Apkarian, A. V. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.019 · Cited by 1 · see citing works
Molecular chaperone heat shock protein 70 inhibitors suppress conditioned place preference induced by morphine exposure in male rats
Wei, S., Li, Y., Gong, Q. H., Liang, H., Bernardi, R. E., & Liang, J. (2022) · Addiction Biology · doi:10.1111/adb.13163 · Cited by 1 · see citing works
Molecular mechanisms underlying the actions of psychoactive drugs in the basal ganglia : Focus on cannabinoids and morphine
Borgkvist, A. (2008) · Figshare
Behavioral and neurobiological consequences of intermittent exposure to addictive drugs.
Rothwell, P. E. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
Neural Mechanisms of Anxiety during Opiate Withdrawal: Role of the Ventral Tegmental Area and Extended Amygdala
Radke, A. K. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)
142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice.
Cynthia Marie-claire, A., Palminteri, S., Romualdi, P., & Noble, F. (2008)
Effect of Glycogen Synthase Kinase 3-β on the Acquisition & Expression of Intra-Accumbal Amphetamine-Induced Conditioned Place Preference in Rats
Quartarone, S. E. (2014) · QSpace (Queen's University Library)
Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking
Galaj, E. (2017) · CUNY Academic Works (City University of New York)
Approach and Avoidance Processing: Investigating a Rostrocaudal Gradient in the Nucleus Accumbens Core
Hamel, L. (2014) · TSpace (University of Toronto)
Hippocampal Lesions in Male Rats Produce Retrograde Memory Loss for Over‐Trained Spatial Memory but Do Not Impact Appetitive‐Contextual Memory: Implications for Theories of Memory Organization in the Mammalian Brain
Hong, N. S., Lee, J. Q., Bonifacio, C. J. T., Gibb, M. J., Kent, M., Nixon, A., Panjwani, M., Robinson, D., Rusnak, V., Trudel, T., et al. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70013
Dopamine, γ-aminobutyric acid, and glutamate balance in the nucleus accumbens shell: Differential effects of cannabinoid 1 receptor agonists Δ9-Tetrahydrocannabinol, AM11101, and AM8936
Smith, E. C., Iliopoulos‐Tsoutsouvas, C., Georgiadis, M., Nikas, S. P., Brijlall, K., Makriyannis, A., & Desai, R. I. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110891

Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition
Spina, L., Fenu, S., Longoni, R., Rivas, E., & Di Chiara, G. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0211-4 · Cited by 102 · see citing works
Roles of the nucleus accumbens (shell) in the acquisition and expression of morphine-induced conditioned behavior in freely moving rats.
Karimi, S., Radahmadi, M., Fazilati, M., Azizi-Malekabadi, H., & Alaei, H. (2014) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Repeated administration of dopaminergic agents in the nucleus accumbens and morphine-induced place preference
Zarrindast, M., Azami, B.-N., Rostami, P., & Rezayof, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.01.011 · Cited by 25 · see citing works
Involvement of dopamine D1 receptors of the central amygdala on the acquisition and expression of morphine-induced place preference in rat
Zarrindast, M., Rezayof, A., Sahraei, H., Haeri-Rohani, A., & Rassouli, Y. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04201-4 · Cited by 74 · see citing works
Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats
Rezaei, Z., Alaei, H., & Reisi, P. (2022) · Advanced Biomedical Research · doi:10.4103/abr.abr_284_21 · Cited by 5 · see citing works

Authors: Fenu, S., Spina, L., Rivas, E., Longoni, R., & Di Chiara, G.
Affiliations: University of Cagliari (IT)
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-05-25
Volume: 187
Issue: 2
Pages: 143-153
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-006-0415-2
OpenAlex: W2011492524
Cited by: 103
References: 64
Citations by year: 2026: 3 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 7 · 2012: 5
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: morphine, conditioned place preference, nucleus accumbens shell, nucleus accumbens core, dopamine D1 receptor, dopamine D2 receptor, dopamine antagonists, SCH 39166, mesolimbic dopamine system
MeSH terms: Animals, Association Learning, Benzazepines, Brain Mapping, Choice Behavior, Conditioning, Classical, Dose-Response Relationship, Drug, Male, Morphine, Narcotics, Nucleus Accumbens, Social Environment, Sulpiride, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats, Dopamine D2 Receptor Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks