Intermale aggression and dark/light preference in ten inbred mouse strains
Abstract
The capacity of males to attack a passive standard opponent in a resident-intruder test and the preferences in a dark/light choice situation were measured in 200 male mice from 10 different inbred mouse strains. Large strain differences were found for all variables recorded, i.e., the proportion of attacking males, the time spent in the brightly lit box, and the number of transitions between the lit and the dark boxes. A strong negative correlation was found between the first two variables. This result suggests that males of more attacking strains have a higher level of anxiety but do not differ for their level of activity. An involvement of GABA as mediating factor is suggested.
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There is huge inter-strain variability in aggressiveness among mice.
“There is also huge inter-strain variability in aggressiveness. 70,71”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [70]
Social hierarchy in mice is maintained through constant, serious aggression, whose intensity can hugely differ between lines.
“Social hierarchy is maintained through constant, serious aggression, 24,96 which intensity can hugely differ between lines.70,91”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [70]
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Characterizing Social Behavior in Genetically Targeted Mouse Models of Brain Disorders
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- Authors
- Guillot, P.-V., & Chapouthier, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Guillot, Pascale-Valerie
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 77
- Issue
- 1-2
- Pages
- 211-213
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2026077662
- Cited by
- 117
- References
- 17
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- male-male aggression, inbred mouse strains, resident-intruder test, anxiety, GABA, activity level, strain differences
- MeSH terms
- Aggression, Agonistic Behavior, Animals, Arousal, Choice Behavior, Darkness, gamma-Aminobutyric Acid, Light, Male, Mice, Inbred Strains, Species Specificity, Mice
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