Cited by 216Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse

Mineur, Yann S., Sluyter, Frans, de Wit, Sanne, Oostra, Ben A., Crusio, Wim E.·2002·Hippocampus

Abstract

Previous studies showed the Fmr1 knockout (KO) mouse to be an excellent animal model for human fragile-X syndrome. The aim of this study was to further characterize the phenotype of these animals. Neuroanatomically, KO male mice were compared to wild-types (littermates) with respect to their sizes of hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields. Behaviorally, they were tested in four different paradigms, each measuring different aspects of cognitive and emotional behavior: elevated plus maze (anxiety), neutral cage (aggression), open field (exploration), and radial maze (spatial memory). The results showed a diminished ability for radial maze learning associated with smaller sizes of IIPMF terminal fields. In addition, Fmr1 knockout animals exhibited increased locomotor activity, while no differences were found for aggression and anxiety. These data suggest the involvement of FMRP protein in the development of spatial learning and the sprouting of IIPMF terminal fields.

Integrity signals

Registry

Crossref · 10.1002/hipo.10005

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Among behavioral phenotypes displayed in Fmr1 KO are deficits in object recognition memory (including a failure to habituate to objects), and impairment of spatial memory.

    “Among the behavioral phenotypes displayed in Fmr1 KO are deficits in object recognition memory (including a failure to habituate to objects), and impairment of spatial memory (Mineur et al., 2002).”
  • Fmr1 KO mice are hyperactive and show indications of increased anxiety and sensory hyperresponsiveness, especially to auditory stimuli.

    “Several studies indicate that Fmr1 KO mice are hyperactive and show indications of increased anxiety (Bakker et al., 1994; Mineur et al., 2002; Spencer et al., 2005) and sensory hyperre-sponsiveness, especially to auditory stimuli (Chen and Toth, 2001; Frankland et al., 2004; Nielsen et al., 2002).”

Cites

Flagged first, then by citations

1 of the 56 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Mineur, Y. S., Sluyter, F., de Wit, S., Oostra, B. A., & Crusio, W. E.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Erasmus University Rotterdam (NL)
  • King's College London (GB)
Corresponding author
Crusio, Wim E.
Venue
Hippocampus
Publisher
Wiley
Published
2002-01
Volume
12
Issue
1
Pages
39-46
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
OpenAlex
W2042310987
Cited by
216
References
56
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 10 · 2014: 21 · 2013: 14 · 2012: 16
FWCI
4.77
Type
journal article
Language
en
Open access
closed
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institutes of Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (5R01 HD 38038, R01HD038038)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Fmr1 knockout mice, fragile X syndrome, FMRP, spatial learning, radial maze, anxiety, aggression, locomotor activity, neuroanatomy, cognitive behavior
MeSH terms
Animals, Anxiety, Behavior, Animal, Disease Models, Animal, Exploratory Behavior, Fragile X Syndrome, Hippocampus, Humans, Male, Memory, Mice, Inbred C57BL, Motor Activity, Nerve Tissue Proteins, RNA-Binding Proteins, Mice, Knockout, Maze Learning, Mossy Fibers, Hippocampal, Mice, Fragile X Messenger Ribonucleoprotein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review