Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease
Abstract
Behavioural and psychological signs and symptoms of dementia encompass a wide range of neuropsychiatric disturbances which coincide with progressing cognitive decline in Alzheimer's disease (AD). Physical aggression and agitation, which occurs in 20-65% of AD patients, is physically and emotionally stressful, not only to patients but also to immediate family and caregivers. The exact mechanisms underlying the increased aggressive behaviour in AD has yet to be elucidated. We used a transgenic mouse model, denoted Tg2576, which over-expresses a mutated human amyloid precursor protein (APP) gene implicated in familial AD, to investigate aggressive behaviour of males at the stage of amyloid beta pathology preceding overt amyloid plaque deposition in the brain. The aggressive behaviour of transgenic and non-transgenic littermate males was evaluated in a standard resident-intruder test in which an isolated resident male responded aggressively toward an experimentally naïve intruder male of A/J strain. We showed that 7-month-old Tg2576 resident males demonstrated significantly higher and unchanged level of aggression towards intruder males during 3 consecutive encounters as compared to their non-transgenic littermate counterparts. These results validate further the Tg2576 mouse model of AD underscoring its usefulness in studying non-mnemonic changes in behaviour related to the disease.
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In the TG2576 mouse, increased aggressive behaviors manifest as increased frequency of attacks on other home cage mice and altered latency to first attack when interacting with a novel mouse.
“in the TG2576 mouse increased aggressive behaviors display themselves in both the frequency of attacks on other home cage mice as well as on the latency to first attack when interacting with a novel mouse”
From Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) · cites this paper as Alexander et al., 2011
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- Authors
- Alexander, G., Hanna, A., Serna, V., Younkin, L., Younkin, S., & Janus, C.
- Affiliations
- Mayo Clinic (US)
- University of Florida (US)
- Corresponding author
- Janus, Christopher
- ORCID
- Janus, Christopher
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 216
- Issue
- 1
- Pages
- 77-83
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2017972820
- Cited by
- 51
- References
- 61
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, aggression, amyloid precursor protein, amyloid-beta pathology, resident-intruder test, neuropsychiatric symptoms, dementia, male behavior, transgenic mouse model
- MeSH terms
- Aggression, Alzheimer Disease, Analysis of Variance, Animals, Behavior, Animal, Disease Models, Animal, Male, Mice, Transgenic, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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