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Cited by 222Neuropeptides and Animal PhysiologyStress Responses and CortisolNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats

Liebsch, Gudrun, Landgraf, Rainer, Gerstberger, Rüdiger, Probst, J.Christopher, Wotjak, Carsten T., Engelmann, Mario, Holsboer, Florian, Montkowski, Alexandra·1995·Regulatory Peptides
DOI 10.1016/0167-0115(95)00099-w
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Abstract

We studied the role of central amygdala CRH receptors in behavioral responses to an anxiogenic stimulus. An antisense oligodeoxynucleotide corresponding to the rat CRH1 receptor mRNA was infused chronically into the central amygdaloid nucleus of male rats via osmotic minipumps (0.25 micrograms/0.5 microliters/h). Control groups received infusions of either a scrambled sequence oligodeoxynucleotide or vehicle. On the 4th day of treatment, rats were subjected to 10 min of social defeat and immediately afterwards tested on the elevated plus-maze. Antisense oligodeoxynucleotide-treated rats spent significantly more time exploring the open arms of the plus-maze than scrambled sequence- and vehicle-treated animals, both of which did not differ from each other. The social discrimination test, on the other hand, revealed no difference in juvenile recognition abilities among the treatment groups. Using in situ hybridization and receptor autoradiography, we were not able to detect clear signals of CRH1 receptor mRNA and CRH binding sites in the central amygdaloid nucleus of either group, confirming the reportedly low expression and density of CRH receptors in this brain area. The present data support the view that CRH receptors in the central nucleus of the amygdala are involved in the mediation and expression of anxiety-related behavior, but simultaneously raise questions as to the mechanisms of antisense oligodeoxynucleotide action.

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Research works printed but not linked: 2

  1. Pich, 1992, Stress-induced release of corticotropin-releasing factor in the amygdala measured by in vivo microdialysis, Soc. Neurosci. Abstr., 18, 535
  2. Neumann, 1994, An oxytocin (OXT) antisense oligonucleotide (AS) infused into the supraoptic nucleus (SON) rapidly alters the excitability of OXT neurons in lactating rats, Soc. Neurosci. Abstr., 20, 1538

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Metadata

Authors
Liebsch, G., Landgraf, R., Gerstberger, R., Probst, J. C., Wotjak, C. T., Engelmann, M., Holsboer, F., & Montkowski, A.
Affiliations
  • Max Planck Institute of Psychiatry (DE)
  • Max Planck Society (DE)
Corresponding author
Montkowski, Alexandra
ORCID
Venue
Regulatory Peptides
Publisher
Elsevier BV
Published
1995-10
Volume
59
Issue
2
Pages
229-239
ISSN
0167-0115 (ISSN-L)
DOI
10.1016/0167-0115(95)00099-w
OpenAlex
W1967569415
Cited by
220
References
51
Citations by year
2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 3
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Regulatory Peptides (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
central amygdala, antisense oligodeoxynucleotides, anxiety-like behavior, social defeat, elevated plus maze, social discrimination, gene silencing
MeSH terms
Amygdala, Animals, Anxiety, Autoradiography, Base Sequence, Behavior, Animal, Discrimination Learning, Infusions, Parenteral, Functional Laterality, Male, Molecular Sequence Data, Social Behavior, Oligonucleotides, Antisense, Rats, Wistar, In Situ Hybridization, Receptors, Corticotropin-Releasing Hormone, Maze Learning, Rats

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