Cited by 222Neuropeptides and Animal PhysiologyStress Responses and CortisolNeuroendocrine regulation and behavior

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Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats

Liebsch, Gudrun, Landgraf, Rainer, Gerstberger, Rüdiger, Probst, J.Christopher, Wotjak, Carsten T., Engelmann, Mario, Holsboer, Florian, Montkowski, Alexandra·1995·Regulatory Peptides

DOI 10.1016/0167-0115(95)00099-w

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Abstract

We studied the role of central amygdala CRH receptors in behavioral responses to an anxiogenic stimulus. An antisense oligodeoxynucleotide corresponding to the rat CRH1 receptor mRNA was infused chronically into the central amygdaloid nucleus of male rats via osmotic minipumps (0.25 micrograms/0.5 microliters/h). Control groups received infusions of either a scrambled sequence oligodeoxynucleotide or vehicle. On the 4th day of treatment, rats were subjected to 10 min of social defeat and immediately afterwards tested on the elevated plus-maze. Antisense oligodeoxynucleotide-treated rats spent significantly more time exploring the open arms of the plus-maze than scrambled sequence- and vehicle-treated animals, both of which did not differ from each other. The social discrimination test, on the other hand, revealed no difference in juvenile recognition abilities among the treatment groups. Using in situ hybridization and receptor autoradiography, we were not able to detect clear signals of CRH1 receptor mRNA and CRH binding sites in the central amygdaloid nucleus of either group, confirming the reportedly low expression and density of CRH receptors in this brain area. The present data support the view that CRH receptors in the central nucleus of the amygdala are involved in the mediation and expression of anxiety-related behavior, but simultaneously raise questions as to the mechanisms of antisense oligodeoxynucleotide action.

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“In addition, injection of CRF antagonists and CRF1R antisense oligonucleotides into the rat amygdala reduces stress-induced, anxiety-like behavior (12, 13).”
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Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
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Effects of psycho-social stress during pregnancy on neuroendocrine and behavioural parameters in lactation depend on the genetically determined stress vulnerability
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“With respect to the relevance of brain CRH in the pathogenesis of, for example, depressive and anxiety disorders (Liebsch et al., 1995; Nemeroff, 1996; Timpl et al., 1998; Kishimoto et al., 2000; Bakshi et al., 2002), differential effects of repeated pregnancy stress on the activity of the CRH system of HAB and LAB ra…”
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Prenatal stress: opposite effects on anxiety and hypothalamic expression of vasopressin and corticotropin‐releasing hormone in rats selectively bred for high and low anxiety
Bosch, O. J., Krömer, S. A., & Neumann, I. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04576.x · Cited by 116
“Two feet in the arm was counted as respective arm entry in order to increase the possibility of counting open arm entries of HAB rats (Liebsch et al., 1995).”
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“These effects are likely to be mediated through the CRH1 receptor, as CRHR1 antagonistic approaches have anxiolytic-like properties in most, but not all anxiety paradigms [Liebsch et al., 1995; Griebel et al., 1998; Muller et al., 2001; Keck et al., 2005].”
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The CRF system and social behavior: a review
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“Animals treated with the antisense oligodeoxynucleotide for 4 days prior to SDS testing showed greater open arm activity following the SDS compared to controls, indicating anxiolytic effect of this treatment (Liebsch et al., 1995).”
Background
Early‐life stress‐induced anxiety‐related behavior in adult mice partially requires forebrain corticotropin‐releasing hormone receptor 1
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“Moreover, suppression of amygdalar CRHR1 by antisense oligonucleotides (Liebsch et al., 1995) or viral-mediated RNA interference (Sztainberg et al.”
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“Thus, it is reasonable to believe that approximately the same degree of CRF1 receptor blockade occurs in other brain regions, i.e., the amygdala which appears to mediate the anxiolytic effects of CRF1 receptor antagonists (Swiergiel et al., 1993; Liebsch et al., 1995, 1999).”
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Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence
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MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
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“Genetic and pharmacological evidence implicates CRF1 in mediating anxiety-related behaviors in animals (Timpl et al., 1998; Smith et al., 1998; Heinrichs et al., 1997; Liebsch et al., 1995; McElroy et al., 2002; Zorrilla et al., 2002, 2003).”
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The Neurobiological Basis of Anxiety and Fear: Circuits, Mechanisms, and Neurochemical Interactions (Part II)
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“CRF1 receptors are located throughout the brain (Van Pett et al., 2000) and play an important role in mediating anxietylike behavior (Liebsch et al., 1995, 1999; Heinrichs et al., 1997; Smith et al., 1998; Timpl et al., 1998; Muller et al., 2003; Zorrilla and Koob, 2004).”
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Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner
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“Under certain conditions, antisense probes against CRF 1 , but not CRF 2 , receptors also display intrinsic anxiolytic activity, although such actions are variable (Skutella et al. 1994; Liebsch et al. 1995; Heinrichs et al. 1997).”
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Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety
Keck, M. E. (2006) · Amino Acids · doi:10.1007/s00726-006-0333-y · Cited by 95
“…mouse models (see below) have indi- cated that CRF1 might be the primary target of interest at which selective compounds should be directed to treat pathological anxiety (Keck and Holsboer, 2001; Liebsch et al., 1995, 1998; Overstreet et al., 2005; Skutella et al., 1998; Timpl et al., 1998).”
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Vasopressin administration modulates anxiety-related behavior in rats
Appenrodt, E., Schnabel, R., & Schwarzberg, H. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00119-x · Cited by 91
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Self-citation
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“CRF-induced ACTH secretion in mouse pituitary AtT-20 cells was previously described by Litvin et al. (1984).”
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Central corticotropin releasing factor and social stress
Bäckström, T., & Winberg, S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00117 · Cited by 76
“Anxiety-like behavior in socially defeated male rats is reduced by injection of antisense oligodeoxynucleotide for CRF-R1 (Liebsch et al., 1995).”
Concordance and incongruence in preclinical anxiety models: Systematic review and meta-analyses
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“The present series of experiments was designed to investigate the eects of chronic rTMS on the behavioral performance of rats in various tests which are known to have the potential to activate the HPA system (Liebsch et al., 1995).”
BackgroundSelf-citation
Release of vasopressin within the brain contributes to neuroendocrine and behavioral regulation
Landgraf, R., Wotjak, C. T., Neumann, I. D., & Engelmann, M. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61571-x · Cited by 66
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Basic Principles of Antisense Therapeutics
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Characterization of [125I]Sauvagine Binding to CRH2 Receptors: Membrane Homogenate and Autoradiographic Studies
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“459 at A SPE T Journals on A ugust 16, 2017 jpet.aspetjournals.org D ow nloaded from tide while CRH2 receptors may be involved in reduction of feeding (Schulz et al., 1996; Lundkvist et al., 1996; Liebsch et al., 1995; Spina et al., 1996).”
Background

Authors: Liebsch, G., Landgraf, R., Gerstberger, R., Probst, J. C., Wotjak, C. T., Engelmann, M., Holsboer, F., & Montkowski, A.
Affiliations: Max Planck Institute of Psychiatry (DE)
Max Planck Society (DE)
Corresponding author: Montkowski, Alexandra
ORCID: Wotjak, Carsten T.
Engelmann, Mario
Venue: Regulatory Peptides
Publisher: Elsevier BV
Published: 1995-10
Volume: 59
Issue: 2
Pages: 229-239
ISSN: 0167-0115 (ISSN-L)
DOI: 10.1016/0167-0115(95)00099-w
OpenAlex: W1967569415
Cited by: 220
References: 51
Citations by year: 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 3
FWCI: 3.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Regulatory Peptides (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: central amygdala, antisense oligodeoxynucleotides, anxiety-like behavior, social defeat, elevated plus maze, social discrimination, gene silencing
MeSH terms: Amygdala, Animals, Anxiety, Autoradiography, Base Sequence, Behavior, Animal, Discrimination Learning, Infusions, Parenteral, Functional Laterality, Male, Molecular Sequence Data, Social Behavior, Oligonucleotides, Antisense, Rats, Wistar, In Situ Hybridization, Receptors, Corticotropin-Releasing Hormone, Maze Learning, Rats

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Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats

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