Cited by 771Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Neurotransmission in the rat amygdala related to fear and anxiety

Davis, Michael, Rainnie, Don, Cassell, Martin·1994·Trends in Neurosciences

Abstract

An impressive amount of evidence from many different laboratories using a variety of experimental techniques indicates that the amygdala plays a crucial role in the acquisition, consolidation and retention or expression of conditioned fear. Electrophysiological data are beginning to detail the transmitters and inter-amygdala connections that transmit information to, within, and out of the amygdala. In general, treatments that increase the excitability of amygdala output neurons in the basolateral nucleus (for example, by decreasing opiate and GABA transmission, and increasing noradrenergic transmission) improve aversive conditioning, whereas treatments that decrease excitability of these neurons (by increasing opiate and GABA transmission, and decreasing NMDA and noradrenergic transmission) retard aversive conditioning as well as producing anxiolytic effects in appropriate animal tests. A better understanding of brain systems that inhibit the amygdala, as well as the role of its very high levels of peptides, might eventually lead to the development of more effective pharmacological strategies for treating clinical anxiety and memory disorders.

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Crossref · 10.1016/0166-2236(94)90106-6

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46 of 46 references verified0 citation errors · 0 not checkable

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  • The amygdala is the critical structure involved in the formation and storage of conditioned fear associations, but it also has a role in many emotional functions including social odor processing and assessing hedonic value of stimuli.

    “The amygdala is considered to be the critical structure involved in the formation and storage of conditioned fear associations (Davis et al., 1994, Phelps and LeDoux, 2005), but it has a role in many emotional functions, including those unrelated to fear, such as social odor processing and assessing hedonic value of stimuli (Holland and Gallagher, 2004, Maren and Fanselow, 1996, Phelps and LeDoux,”

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Authors
Davis, M., Rainnie, D., & Cassell, M.
Affiliations
  • Yale University (US)
  • University of Iowa (US)
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1994-01
Volume
17
Issue
5
Pages
208-214
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2055875395
Cited by
771
References
46
Citations by year
2026: 1 · 2025: 4 · 2024: 32 · 2023: 8 · 2022: 10 · 2021: 6 · 2020: 16 · 2019: 11 · 2018: 15 · 2017: 22 · 2016: 19 · 2015: 16 · 2014: 23 · 2013: 29 · 2012: 28
FWCI
4.42
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ns025139-02)
  • National Institute of Mental Health (NIMH MH-47840, NIMH MH-00004)
  • National Institute of Neurological Disorders and Stroke (NIMH NS25139)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
amygdala, neurotransmission, fear conditioning, anxiety, basolateral amygdala, aversive conditioning, GABA transmission, noradrenergic neurotransmission, anxiolytic effects, memory consolidation
MeSH terms
Amino Acids, Amygdala, Animals, Anxiety, Behavior, Animal, Electrophysiology, Fear, Neural Pathways, Synaptic Transmission, Rats

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