CoChat
Sign Up
Cited by 222Neuropeptides and Animal PhysiologyStress Responses and CortisolNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats

Liebsch, Gudrun, Landgraf, Rainer, Gerstberger, Rüdiger, Probst, J.Christopher, Wotjak, Carsten T., Engelmann, Mario, Holsboer, Florian, Montkowski, Alexandra·1995·Regulatory Peptides
DOI 10.1016/0167-0115(95)00099-w
Open this paper in CoChat — free account

Abstract

We studied the role of central amygdala CRH receptors in behavioral responses to an anxiogenic stimulus. An antisense oligodeoxynucleotide corresponding to the rat CRH1 receptor mRNA was infused chronically into the central amygdaloid nucleus of male rats via osmotic minipumps (0.25 micrograms/0.5 microliters/h). Control groups received infusions of either a scrambled sequence oligodeoxynucleotide or vehicle. On the 4th day of treatment, rats were subjected to 10 min of social defeat and immediately afterwards tested on the elevated plus-maze. Antisense oligodeoxynucleotide-treated rats spent significantly more time exploring the open arms of the plus-maze than scrambled sequence- and vehicle-treated animals, both of which did not differ from each other. The social discrimination test, on the other hand, revealed no difference in juvenile recognition abilities among the treatment groups. Using in situ hybridization and receptor autoradiography, we were not able to detect clear signals of CRH1 receptor mRNA and CRH binding sites in the central amygdaloid nucleus of either group, confirming the reportedly low expression and density of CRH receptors in this brain area. The present data support the view that CRH receptors in the central nucleus of the amygdala are involved in the mediation and expression of anxiety-related behavior, but simultaneously raise questions as to the mechanisms of antisense oligodeoxynucleotide action.

Overview

Integrity signals

Registry

Crossref · 10.1016/0167-0115(95)00099-w

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Pich, 1992, Stress-induced release of corticotropin-releasing factor in the amygdala measured by in vivo microdialysis, Soc. Neurosci. Abstr., 18, 535
  2. Neumann, 1994, An oxytocin (OXT) antisense oligonucleotide (AS) infused into the supraoptic nucleus (SON) rapidly alters the excitability of OXT neurons in lactating rats, Soc. Neurosci. Abstr., 20, 1538

Cited by

Sorted by citations

See all 222

Related

See all

Metadata

Authors
Liebsch, G., Landgraf, R., Gerstberger, R., Probst, J. C., Wotjak, C. T., Engelmann, M., Holsboer, F., & Montkowski, A.
Affiliations
  • Max Planck Institute of Psychiatry (DE)
  • Max Planck Society (DE)
Corresponding author
Montkowski, Alexandra
ORCID
Venue
Regulatory Peptides
Publisher
Elsevier BV
Published
1995-10
Volume
59
Issue
2
Pages
229-239
ISSN
0167-0115 (ISSN-L)
DOI
10.1016/0167-0115(95)00099-w
OpenAlex
W1967569415
Cited by
220
References
51
Citations by year
2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 3
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Regulatory Peptides (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
central amygdala, antisense oligodeoxynucleotides, anxiety-like behavior, social defeat, elevated plus maze, social discrimination, gene silencing
MeSH terms
Amygdala, Animals, Anxiety, Autoradiography, Base Sequence, Behavior, Animal, Discrimination Learning, Infusions, Parenteral, Functional Laterality, Male, Molecular Sequence Data, Social Behavior, Oligonucleotides, Antisense, Rats, Wistar, In Situ Hybridization, Receptors, Corticotropin-Releasing Hormone, Maze Learning, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review