The influence of a vasopressin-analogue (DGAVP) on event-related potentials in a stimulus-mismatch paradigm
Abstract
To assess the influence of DGAVP (des-glycinamide-arginine-8-vasopressin, a synthetic vasopressin analogue) on the processing of stimuli and stimulus deviance in humans in a double-blind cross-over experiment, 13 subjects received 60 IU DGAVP versus placebo intranasally 48, 24, and 1 h prior to the experimental session. Auditory event-related potentials (ERPs) were taken as a tool to investigate central nervous processing in an experimental task that required the subjects to count different kinds of rare tone pips deviating in pitch and probability compared to frequent standard tones. Direction of attention was manipulated by instructing the subject to count a different class of deviating tone pips in each attention condition. DGAVP enhanced the N2 of the ERP to tone pips deviating extremely in pitch from standard tones, whether or not the extremely deviating pips were to be attended to by the subjects. This influence suggests an intensified mismatch processing under DGAVP that may result from a general excitatory effect of this substance on cortical activity.
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Intravenous administration of vasopressin enhanced plasma vasopressin but did not affect brain activity measured by event-related potentials.
“More importantly, intravenous administration of AVP enhanced plasma AVP but did not affect the brain activity (measured by ERP) (Pietrowsky et al. 1989), showing that the effects after IN-AVP are not dependent on the AVP plasma concentration.”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Pietrowsky et al. 1989
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- Authors
- Pietrowsky, R., Born, J., Fehm-Wolfsdorf, G., & Fehm, H. L.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Pietrowsky, R.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 1989-06
- Volume
- 28
- Issue
- 3
- Pages
- 239-250
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2025301235
- Cited by
- 8
- References
- 24
- Citations by year
- 2017: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- vasopressin analogue, auditory event-related potentials, N2 component, attentional bias, pitch deviance, intranasal administration, cortical excitability
- MeSH terms
- Administration, Intranasal, Adult, Arginine Vasopressin, Arousal, Attention, Clinical Trials as Topic, Double-Blind Method, Electroencephalography, Evoked Potentials, Auditory, Humans, Male, Pitch Discrimination
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