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Cited by 67Neuroendocrine regulation and behaviorSleep and Wakefulness ResearchNeuropeptides and Animal Physiology

Vasopressin but not oxytocin enhances cortical arousal: an integrative hypothesis on behavioral effects of neurohypophyseal hormones

Fehm-Wolfsdorf, Gabriele, Bachholz, Georg, Born, Jan, Voigt, Karlheinz, Fehm, Horst Lorenz·1988·Psychopharmacology
DOI 10.1007/bf00212844
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Abstract

Behavioral changes after administration of the neurohypophyseal hormones vasopressin and oxytocin can be observed in animal and man. Several groups attempted to specify these changes in terms of memory or attention processing enhancement for vasopressin and amnesic properties for oxytocin. These interpretations, however, were targets for recent criticism. In a double-blind between-subject comparison with male volunteers receiving arginine-vasopressin (AVP), oxytocin or placebo intranasally prior to the experimental session, we tried to develop an alternative hypothesis on the basis of behavioral and EEG measures. At the beginning of the session subjects had to learn a list of 25 unrelated nouns within five trials. Recall was assessed 1 h later. Neither learning nor long-term recall were affected by peptide treatments. In a second vigilance task subjects had to covertly count eight series of tone pips. Averaged auditory evoked potentials to these tones showed the expected habituation during the course of the task within all three groups. Vasopressin-treated subjects, however, displayed significantly higher amplitudes of the vertex potential as compared to the other treatment groups. AVP effects were most prominent with the longest interstimulus interval. No influences on heart rate or blood pressure were found. Results indicate that vasopressin induces an enhancement of stimulus-related phasic cortical arousal, and that in this respect oxytocin has no effect.

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  • Intranasal vasopressin increased the amplitude of several components of late event-related potentials, in particular P3, which reflects higher cognitive and attention processing.

    “IN-AVP increased the amplitude of several components of the late ERPs, in particular the amplitude of P3, which reflects a higher level of cognitive and attention processing (Born et al. 1986; Fehm-Wolfsdorf et al. 1988; Naumann et al. 1991; Pietrowsky et al. 1989).”

    From A precision medicine approach to oxytocin trials (2017) · cites this paper as Fehm-Wolfsdorf et al. 1988

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Authors
Fehm-Wolfsdorf, G., Bachholz, G., Born, J., Voigt, K., & Fehm, H. L.
Affiliations
Universität Ulm (DE)
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1988-04
Volume
94
Issue
4
Pages
496-500
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf00212844
OpenAlex
W2066465114
Cited by
67
References
19
Citations by year
2024: 2 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
6.53
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
vasopressin, oxytocin, neurohypophyseal hormones, cortical arousal, vertex potential, auditory evoked potentials, sustained attention, memory, intranasal administration, habituation, interstimulus interval
MeSH terms
Adult, Arousal, Blood Pressure, Evoked Potentials, Auditory, Heart Rate, Humans, Learning, Male, Memory, Oxytocin, Vasopressins

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