Vasopressin and electrophysiological signs of attention in man
Abstract
Seventeen pairs of monozygotic twins, females and males, were tested in a dichotic listening task, containing several types of pips: standard and deviating target pips, which the subject either attended to, or not. Averaged auditory evoked potentials (AEPs) to the pips provided measures of different attentional processes. Furthermore, EEG power spectra, heart rate and blood pressure and behavioral performance were measured. Subjects received treatments (20 I.U. lysine-vasopressin vs. placebo) intranasally 48, 24, and 1 hour prior to the experimental sessions according to a co-twin control design. Whereas measures of voluntary selective attention remained unchanged by lysine-vasopressin (LVP) the peptide primarily affected an attentional mechanism responding in an automatic fashion to stimulus deviance. This effect was indicated by a substantial negative shift of the AEP amplitudes following deviating stimuli within the latency range of the N2/P2 components (about 200 msec post-stimulus). The effect seemed to be unrelated to modulations of cortical arousal after LVP.
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Intranasal vasopressin significantly enhances vasopressin concentration in cerebrospinal fluid in a dose-dependent manner, with a fivefold increase at 40 IU and a tenfold increase at 80 IU.
“In addition to the effects of IN-AVP on brain activity, researchers showed that it enhances significantly AVP concentration in the CSF in a dose-dependent manner (fivefold increase with 40 IU and tenfold with 80 IU) (Born et al. 1986).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Born et al. 1986
Intranasal vasopressin increased the amplitude of several components of late event-related potentials, in particular P3, which reflects higher cognitive and attention processing.
“IN-AVP increased the amplitude of several components of the late ERPs, in particular the amplitude of P3, which reflects a higher level of cognitive and attention processing (Born et al. 1986; Fehm-Wolfsdorf et al. 1988; Naumann et al. 1991; Pietrowsky et al. 1989).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Born et al. 1986
Mean cerebrospinal fluid concentrations began to rise within 10 minutes of intranasal administration and stayed above placebo groups 100 to 120 minutes after intake.
“Mean CSF concentrations began to rise within 10 min of intranasal administration and stayed above those in placebo groups 100–120 min after intake.”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Born et al. 1986
Cites
Electrical Signs of Selective Attention in the Human Brain
Hillyard, S. A., Hink, R. F., Schwent, V. L., & Picton, T. W. (1973) · Science · doi:10.1126/science.182.4108.177 · Cited by 1,938 · see citing works
Donchin, E. (1981) · Psychophysiology · doi:10.1111/j.1469-8986.1981.tb01815.x · Cited by 1,857 · see citing works
Processing negativity: An evoked-potential reflection.
Näätänen, R. (1982) · Psychological Bulletin · doi:10.1037/0033-2909.92.3.605 · Cited by 687 · see citing works
Stimulus deviance and evoked potentials
Näätänen, R., Simpson, M., & Loveless, N. E. (1982) · Biological Psychology · doi:10.1016/0301-0511(82)90017-5 · Cited by 597 · see citing works
Parasuraman, R. (1980) · Biological Psychology · doi:10.1016/0301-0511(80)90057-5 · Cited by 142 · see citing works
Average evoked response and stimulus intensity in identical and fraternal twins
Buchsbaum, M. S. (1974) · Physiological Psychology · doi:10.3758/bf03333041 · Cited by 128 · see citing works
Neurobiology of Sleep and Memory
Peters, B. H. (1978) · Archives of Neurology · doi:10.1001/archneur.1978.00500270066019 · Cited by 122 · see citing works
Selective auditory attention and early event-related potentials: A rejoinder.
Hillyard, S. A. (1981) · Canadian Journal of Psychology/Revue Canadienne de Psychologie · doi:10.1037/h0081155 · Cited by 112 · see citing works
Neuropeptides and psychosomatic processes
Endröczi, E., & Fidia, F. (1983) · Akadémiai Kiadó eBooks · Cited by 91 · see citing works
Human memory and neurohypophyseal hormones: Opposite effects of vasopressin and oxytocin
Fehm‐Wolfsdorf, G., Jan Born, A., Voigt, K., & Fehm, H. (1984) · Psychoneuroendocrinology · doi:10.1016/0306-4530(84)90007-6 · Cited by 91 · see citing works
Self-citationEEG spectra in twins: Evidence for a neglected mechanism of genetic determination
Lykken, D. T., Tellegen, A., & Iacono, W. G. (1982) · Physiological Psychology · doi:10.3758/bf03327008 · Cited by 86 · see citing works
Vasopressin analog influences the performance of males on a reaction time task
Beckwith, B. E., Couk, D. I., & Till, T. S. (1983) · Peptides · doi:10.1016/0196-9781(83)90022-0 · Cited by 48 · see citing works
Koob, G. F. (1987) · Springer eBooks · doi:10.1007/978-1-4613-1819-4_9 · Cited by 40 · see citing works
MSH/ACTH 4–10 in men and women: Effects upon performance of an attention and memory task
Ward, M. M., Sandman, C. A., George, J. M., & Shulman, H. G. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90228-2 · Cited by 36 · see citing works
Behavioral Effects of Vasopressin
Fehm‐Wolfsdorf, G., Jan Born, A., Voigt, K., & Fehm, L. (2008) · Neuropsychobiology · doi:10.1159/000118050 · Cited by 22 · see citing works
Self-citationAn ACTH 4-9 analog impairs selective attention in man
Jan Born, A., Fehm‐Wolfsdorf, G., Schiebe, M., Birbaumer, N., Fehm, H. L., & Voigt, K. H. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90308-x · Cited by 21 · see citing works
Self-citationVasopressin does not enhance memory processes: A study in human twins
Fehm‐Wolfsdorf, G., Jan Born, A., Elbert, T. R., Voigt, K., & Fehm, H. L. (1985) · Peptides · doi:10.1016/0196-9781(85)90055-5 · Cited by 20 · see citing works
Self-citationPITUITARY PEPTIDE INFLUENCES ON ATTENTION AND MEMORY
Sandman, C. A., & Kastin, A. J. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-222350-1.50025-8 · Cited by 16 · see citing works
Influences of ACTH 4–10 on event-related potentials reflecting attention in man
Born, J., Fehm‐Wolfsdorf, G., VOIGT, K., et al. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90348-9 · Cited by 10 · see citing works
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Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Fehm-Wolfsdorf, G., Bachholz, G., Born, J., Voigt, K., & Fehm, H. L. (1988) · Psychopharmacology · doi:10.1007/bf00212844 · Cited by 67 · see citing works
Self-citationDecay time of the auditory sensory memory trace during wakefulness and REM sleep.
Atienza, M., Cantero, J. L., & Gómez, C. M. (2000) · Psychophysiology · doi:10.1111/1469-8986.3740485 · Cited by 54 · see citing works
Neuropsychological effects of vasopressin in healthy humans
Born, J., Pietrowsky, R., & L. Fehm, H. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61595-2 · Cited by 42 · see citing works
A precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40 · see citing works
McEwen (2004) · doi:10.1016/s1054-3589(04)50016-9 · Cited by 22 · see citing works
Vasopressin and cognitive processes: Two event-related potential studies
Naumann, E., Bartussek, D., Kaiser, W., & Fehm-Wolfsdorf, G. (1991) · Peptides · doi:10.1016/0196-9781(91)90223-c · Cited by 15 · see citing works
Self-citationPietrowsky, R., Born, J., Fehm-Wolfsdorf, G., & Fehm, H. L. (1989) · Biological Psychology · doi:10.1016/0301-0511(89)90003-3 · Cited by 8 · see citing works
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- Authors
- Born, J., Fehm-Wolfsdorf, G., Lutzenberger, W., Voigt, K. H., & Fehm, H. L.
- Affiliations
- Universität Ulm (DE)
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 7
- Issue
- 2
- Pages
- 189-193
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W1996057338
- Cited by
- 69
- References
- 19
- Citations by year
- 2024: 1 · 2020: 1 · 2017: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- vasopressin, lysine vasopressin, attention, dichotic listening, auditory evoked potentials, selective attention, automatic attention, EEG power spectra, heart rate, blood pressure, monozygotic twins, co-twin control, intranasal administration
- MeSH terms
- Adolescent, Adult, Attention, Blood Pressure, Brain, Electroencephalography, Evoked Potentials, Auditory, Female, Heart Rate, Humans, Lypressin, Male, Middle Aged, Twins, Monozygotic
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