Cited by 42Neuroendocrine regulation and behaviorMemory and Neural MechanismsOlfactory and Sensory Function Studies

Neuropsychological effects of vasopressin in healthy humans

Born, Jan, Pietrowsky, Reinhard, L. Fehm, Horst·1999·Progress in brain research

Abstract

Animal research indicated that vasopressin (VP) exerts its principle behavioral influence, the improvement of memory formation, through an action on septo-hippocampal and connected limbic structures. Here human research is reviewed with the notion of a comparable effect of VP in healthy humans. Although the human studies yielded less consistent results than those in rats, they indicate that VP is able to improve declarative memory formation which is the type of memory essentially relying on hippocampal function. The effect appears to center on the encoding process for memory. In examinations of event-related brain potentials (ERPs) VP was consistently found to increase the 'mismatch negativity' (MMN) and the P3 components which are ERP potentials closely linked to the hippocampal processing of novel, unexpected and salient events. Enhanced processing of these stimulus aspects is considered to precipitate memory encoding. The regulation of voluntary selective attention and arousal do not appear to be primary targets of VP effects in humans. A mediation of effects by peripheral changes can be excluded since the central nervous effects were observed in studies using intranasal VP administration providing a direct access to brain functions.

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Crossref · 10.1016/s0079-6123(08)61595-2

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Authors
Born, J., Pietrowsky, R., & L. Fehm, H.
Affiliations
University of Lübeck (DE)
Venue
Progress in brain research
Publisher
Elsevier
Published
1999
Volume
119
Pages
619-642
ISSN
0079-6123 (ISSN-L)
OpenAlex
W1562350601
Cited by
42
References
122
Citations by year
2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
8.58
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
vasopressin, memory formation, declarative memory, hippocampus, septo-hippocampal system, limbic system, memory encoding, event-related potentials, mismatch negativity, P300, intranasal administration, selective attention, arousal
MeSH terms
Animals, Humans, Limbic System, Memory, Neuropsychological Tests, Vasoconstrictor Agents, Vasopressins, Rats

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