CoChat
Sign Up
Cited by 433Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

Braak, Heiko, Braak, Eva, Grundke-Iqbal, Inge, Iqbal, Khalid·1986·Neuroscience Letters
DOI 10.1016/0304-3940(86)90288-0
Open this paper in CoChat — free account

Abstract

Paired helical filaments, pathologically changed components of the cytoskeleton of human nerve cells, are demonstrated by a specific silver staining technique, immunostaining and electron microscopy. Accumulations of these filaments are found in the telencephalic cortex of old-aged individuals and patients suffering from Alzheimer's disease. Apart from neurofibrillary tangles and neuritic plaques, paired helical filaments are encountered in neuropil threads. At this third location, pathological filaments occur in small and inconspicuous profiles scattered throughout both allocortical and isocortical areas. The pattern of distribution and packing density of neuropil threads varies between different cortical areas and layers.

Overview

Integrity signals

Registry

Crossref · 10.1016/0304-3940(86)90288-0

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 14 references

Cited by

Sorted by citations

Items 401–433 of 433

Related

See all

Metadata

Authors
Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K.
Corresponding author
Braak, Heiko
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1986-04
Volume
65
Issue
3
Pages
351-355
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/0304-3940(86)90288-0
OpenAlex
W1984827962
Cited by
432
References
14
Citations by year
2026: 1 · 2025: 9 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
12.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG-05892, AG/NS-04220)
  • National Institute of Neurological Disorders and Stroke (NS 18105)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neuropil threads, paired helical filaments, Alzheimer's disease, neurofibrillary tangles, neuritic plaques, cytoskeletal filaments, silver staining, immunostaining, electron microscopy, cortical layers
MeSH terms
Aged, Aging, Alzheimer Disease, Brain, Cytoskeleton, Humans, Immune Sera, Intermediate Filaments, Microscopy, Electron, Middle Aged, Neurofibrils, Silver, Staining and Labeling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review