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Cited by 226Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

The dopaminergic innervation of the supraoptic and paraventricular nucleus. A light and electron microscopical study

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Buijs, R.M., Geffard, M., Pool, C.W., Hoorneman, E.M.D.·1984·Brain Research
DOI 10.1016/0006-8993(84)90265-8
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Abstract

An antiserum that has been raised against glutaraldehyde-conjugated dopamine was used to demonstrate specifically dopamine in the rat hypothalamus. This dopamine antiserum permitted an optimal fixation with glutaraldehyde and therefore enabled the simultaneous light and electron microscopic immunocytochemical localization of dopamine. It was demonstrated that the paraventricular and supraoptic nuclei of the hypothalamus were innervated by thin dopaminergic fibers, in contrast to the suprachiasmatic nucleus, which hardly received any dopaminergic input. Ultrastructural observations revealed that the dopamine fibers terminated synaptically on the magnocellular neurons and their processes. It is concluded that the present results may explain the effect of centrally injected dopamine on vasopressin and oxytocin release. In the dopamine-containing terminals the reaction product was frequently observed in 90 nm dense core vesicles and around clear vesicles.

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Cites

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  • The PVN and the SON express DA receptors and receive dopaminergic innervations, possibly from the VTA.

    “Additionally, the PVN and the SON express DA receptors and receive dopaminergic innervations, possibly from the VTA (Buijs et al., 1984; Decavel et al., 1987; He et al., 2021; Rivkees and Lachowicz, 1997).”

    From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Buijs et al., 1984

    The Discussion (pp. 6–7) concludes that the PVN and SON receive dopaminergic fibers and suggests that the VTA may be their source. The paper does not establish that either nucleus expresses dopamine receptors; its observations concern dopamine-containing fibers and their synaptic contacts. (LLM, conf=0.88)

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  • The VTA, NAc, and AMY express both OXTR and DA receptors.

    “In addition, the VTA, NAc, and AMY express both OXTR and DA receptors (Baskerville et al., 2009; Buijs et al., 1984; Roeling et al., 1993).”

    From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Buijs et al., 1984

    The Discussion (p. 7) suggests that the VTA may be a source of dopamine fibers innervating the PVN and SON; it does not describe receptor expression in the VTA. Searches for OXTR, dopamine receptors, the NAc, and the amygdala found no passage establishing that these three regions express both receptor types. (LLM, conf=0.78)

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Cites

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1 of the 31 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. 13 Lindvall, O., Björklund, A. and Skagerberg, G., New dopaminergic innervations in the thalamus and hypothalamus: visualization after extensive neurotoxin-induced depletion of forebrain noradrenaline, Proc. 5th CA Symposium, Göteborg, 1983, p. 208.

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Authors
Buijs, R. M., Geffard, M., Pool, C. W., & Hoorneman, E. M. D.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Buijs, R.M.
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
1984-12
Volume
323
Issue
1
Pages
65-72
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(84)90265-8
OpenAlex
W2126473406
Cited by
226
References
31
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 4
FWCI
20.68
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
dopaminergic innervation, supraoptic nucleus, paraventricular nucleus, hypothalamus, magnocellular neurons, vasopressin release, oxytocin release, suprachiasmatic nucleus, synaptic terminals, dense core vesicles, clear vesicles, ultrastructure
MeSH terms
Animals, Dopamine, Immunoenzyme Techniques, Male, Microscopy, Electron, Oxytocin, Paraventricular Hypothalamic Nucleus, Rats, Inbred Strains, Supraoptic Nucleus, Vasopressins, Rats

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