Synaptic plasticity in the rat supraoptic nucleus during lactation involves GABA innervation and oxytocin neurons: a quantitative immunocytochemical analysis
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The hypothalamic supraoptic nucleus (SON) is known to undergo synaptic remodeling in response to physiological stimuli, such as lactation. We here investigated the involvement of the GABAergic innervation in such plasticity by carrying out comparative ultrastructural analyses after postembedding immunogold labeling for GABA on sections of the SON from virgin and lactating rats. Using random single-section analysis to estimate the numerical density of synapses (from areal measurements of the anterior, mid, and posterior portions of the nucleus), we found that the overall density in either group was about 35 x 10(6) synapses/mm3, of which over one-third were GABA immunoreactive. The GABAergic terminals formed mainly symmetrical synaptic contact on neurosecretory somata and dendrites; the density of axodendritic contacts was twice that of axosomatic contacts. Despite hypertrophy of the neurosecretory neurons in lactating rats, the overall synaptic density did not diminish and was similar to that evaluated in virgin rats. When we estimated synaptic densities in the neuropil (by subtracting the proportion of sampled areas occupied by soma profiles), we found a statistically significant increase in the density of GABAergic synapses, in particular in the mid and posterior portions of the SON in lactating animals. On the other hand, the density of GABA- immunonegative synapses did not differ in the two groups. Terminals contacting more than one postsynaptic element in the same plane of section (“shared” synapses) were visible in the nuclei of virgin and lactating rats and about half in each group were GABAergic. They were comparatively rare but their incidence doubled in lactating animals.(ABSTRACT TRUNCATED AT 250 WORDS)
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Hypothalamic inhibition increases during lactation and might prevent activation of oxytocin neurons by sparse synaptic inputs.
“Hypothalamic inhibition increases during lactation46 and might prevent the activation of oxytocin neurons by sparse synaptic inputs”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [46]
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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,141 · see citing works
Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
Poulain, D. A., & Wakerley, J. B. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90044-6 · Cited by 813 · see citing works
GABA: A dominant neurotransmitter in the hypothalamus
Decavel, C., & van den Pol, A. N. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020423 · Cited by 571 · see citing works
Glutamate, the Dominant Excitatory Transmitter in Neuroendocrine Regulation
van den Pol, A. N., Wuarin, J., & Dudek, F. E. (1990) · Science · doi:10.1126/science.1978759 · Cited by 541 · see citing works
Rhodes, C. H., Morriell, J. I., & Pfaff, D. W. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980106 · Cited by 536 · see citing works
Hatton, G. I. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90017-b · Cited by 439 · see citing works
Sawchenko, P. E., Swanson, L. W., Steinbusch, H. W. M., & Verhofstad, A. A. J. (1983) · Brain Research · doi:10.1016/0006-8993(83)90945-9 · Cited by 380 · see citing works
Roland, B. L., & Sawchenko, P. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903320109 · Cited by 334 · see citing works
Antibodies against gamma-aminobutyric acid: specificity studies and immunocytochemical results.
Séguéla, P., Geffard, M., Buijs, R. M., & Moal, M. L. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3888 · Cited by 331 · see citing works
Ben-Barak, Y., Russell, J., Whitnall, M., Ozato, K., & Gainer, H. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-01-00081.1985 · Cited by 313 · see citing works
Activity-dependent neuronal-glial and synaptic plasticity in the adult mammalian hypothalamus
Theodosis, D. T., & Poulain, D. A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90002-w · Cited by 273 · see citing works
Self-citationOxytocin induces morphological plasticity in the adult hypothalamo-neurohypophysial system
Theodosis, D. T., Montagnese, C. M., Rodriguez, F., Vincent, J., & Poulain, D. A. (1986) · Nature · doi:10.1038/322738a0 · Cited by 211 · see citing works
Self-citationWitkin, J. W., Ferin, M., Popilskis, S. J., & Silverman, A. (1991) · Endocrinology · doi:10.1210/endo-129-2-1083 · Cited by 207 · see citing works
Synaptic remodeling in the rat arcuate nucleus during the estrous cycle
Olmos, G., Naftolin, F. N., Perez, J., Tranque, P., & García‐Segura, L. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90288-1 · Cited by 202 · see citing works
Theodosis, D. T., & Poulain, D. A. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90222-7 · Cited by 191 · see citing works
Self-citationTheodosis, D. T., Paut-Pagano, L., & Tappaz, M. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90016-3 · Cited by 179 · see citing works
Self-citationTheodosis, D. T., Chapman, D. B., Montagnese, C. M., Poulain, D. A., & Morris, J. F. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90038-2 · Cited by 177 · see citing works
Self-citationTheodosis, D. T., Poulain, D. A., & Vincent, J. D. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90173-1 · Cited by 176 · see citing works
Self-citationTribollet, E., Armstrong, W. E., Dubois‐Dauphin, M., & Dreifuss, J. J. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90128-9 · Cited by 158 · see citing works
Hatton, G. I., & Tweedle, C. D. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90046-6 · Cited by 157 · see citing works
Tweedle, C. D., & Hatton, G. I. (1984) · Brain Research · doi:10.1016/0006-8993(84)90607-3 · Cited by 148 · see citing works
Decavel, C., & van den Pol, A. N. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160109 · Cited by 145 · see citing works
Nerve Terminal Remodeling Visualized in Living Mice by Repeated Examination of the Same Neuron
Purves, D., Voyvodic, J. T., Magrassi, L., & Yawo, H. (1987) · Science · doi:10.1126/science.3685967 · Cited by 129 · see citing works
Ultrastructural localization of GABA in the supraoptic nucleus and neural lobe
Buijs, R. M., Vulpen, E. H. S. V., & Geffard, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90025-x · Cited by 128 · see citing works
Chapman, D. B., Theodosis, D. T., Montagnese, C. M., Poulain, D. A., & Morris, J. F. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90039-4 · Cited by 127 · see citing works
Self-citationQuantitative studies on the supraoptic nucleus in the rat. I. Synaptic organization
L�r�nth, C., Z�borszky, L., Márton, J., & Palkovits, M. (1975) · Experimental Brain Research · doi:10.1007/bf00237351 · Cited by 126 · see citing works
Fénelon, V. S., Poulain, D. A., & Theodosis, D. T. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90286-o · Cited by 125 · see citing works
Self-citationEstradiol induces plasticity of gabaergic synapses in the hypothalamus
Párducz, Á., Perez, J., & García‐Segura, L. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90203-r · Cited by 117 · see citing works
Colonnier, M., & Beaulieu, C. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902310205 · Cited by 114 · see citing works
Merighi, A., Polak, J. M., Fumagalli, G. F., & Theodosis, D. T. (1989) · Journal of Histochemistry & Cytochemistry · doi:10.1177/37.4.2564404 · Cited by 102 · see citing works
Self-citationvan den Pol, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-11-02940.1985 · Cited by 100 · see citing works
Effect of the richness of the environment on the cat visual cortex
Beaulieu, C., & Colonnier, M. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902660404 · Cited by 99 · see citing works
Actions of gamma‐aminobutyric acid on rat supraoptic nucleus neurosecretory neurones in vitro.
Randle, J. C. R., & Renaud, L. P. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016592 · Cited by 98 · see citing works
Quantitative studies on the supraoptic nucleus in the rat. II. Afferent fiber connections
Z�borszky, L., L�r�nth, C., Makara, G. B., & Palkovits, M. (1975) · Experimental Brain Research · doi:10.1007/bf00237352 · Cited by 94 · see citing works
Ultrastructural studies on the hypothalamic neurosecretory neurons of the rat
Kalimo, H., & Rinne, U. K. (1972) · Cell and Tissue Research · doi:10.1007/bf00307154 · Cited by 90 · see citing works
Jhamandas, J. H., Raby, W. N., Rogers, J., Buijs, R. M., & Renaud, L. P. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902820103 · Cited by 89 · see citing works
Montagnese, C. M., Poulain, D. A., Vincent, J. D., & Theodosis, D. T. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1150097 · Cited by 86 · see citing works
Self-citationDecavel, C., Geffard, M., & Calas, A. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90577-5 · Cited by 83 · see citing works
Theodosis, D. T., & Poulain, D. A. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90014-2 · Cited by 79 · see citing works
Self-citationRandle, J. C. R., Bourque, C. W., & Renaud, L. P. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.6.1703 · Cited by 76 · see citing works
Radial Glia‐Like Cells in the Supraoptic Nucleus of the Adult Rat
Bonfanti, L., Poulain, D. A., & Theodosis, D. T. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00357.x · Cited by 74 · see citing works
Self-citationMeeker, R. B., Swanson, D. J., & Hayward, J. N. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90318-7 · Cited by 72 · see citing works
Ultrastructural studies on the hypothalamic neurosecretory neurons of the rat
Kalimo, H. (1975) · Cell and Tissue Research · doi:10.1007/bf00221723 · Cited by 67 · see citing works
Modney, B. K., & Hatton, G. I. (1989) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1989.tb00072.x · Cited by 64 · see citing works
Hartman, R. D., Rosella-Dampman, L. M., & Summy‐Long, J. Y. (1987) · Endocrinology · doi:10.1210/endo-121-2-536 · Cited by 44 · see citing works
Katsumaru, H., Murakami, F., Wu, J., & Tsukahara, N. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02864.1986 · Cited by 37 · see citing works
Alterations in supraoptic nucleus ultrastructure of maternally behaving virgin rats
Salm, A. K., Modney, B. K., & Hatton, G. I. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90209-2 · Cited by 34 · see citing works
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Activity-dependent structural and functional plasticity of astrocyte-neuron interactions
Theodosis, D. T., Poulain, D. A., & Oliet, S. H. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00036.2007 · Cited by 531 · see citing works
Self-citationEngelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450 · see citing works
Physiology of BDNF: focus on hypothalamic function
Tapia‐Arancibia, L. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.04.001 · Cited by 367 · see citing works
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 338 · see citing works
Dendritic Release of Vasopressin and Oxytocin
Ludwig (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00279.x · Cited by 342 · see citing works
Function-related plasticity in hypothalamus.
Hatton, G. I. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.375 · Cited by 331 · see citing works
Activity-dependent neuronal-glial and synaptic plasticity in the adult mammalian hypothalamus
Theodosis, D. T., & Poulain, D. A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90002-w · Cited by 273 · see citing works
Self-citationMorphological and electrophysiological classification of hypothalamic supraoptic neurons
Armstrong, W. E. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)80005-s · Cited by 246 · see citing works
Brussaard, A. B., Kits, K. S., Baker, R. E., Willems, W. P. A., Leyting-Vermeulen, J. W., Voorn, P., Smit, A. B., Bicknell, R. J., & Herbison, A. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80401-8 · Cited by 228 · see citing works
Theodosis, D. T. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0226 · Cited by 219 · see citing works
Self-citationHussy, N., Deleuze, C., Desarménien, M. G., & Moos, F. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00071-4 · Cited by 203 · see citing works
Russell, J. A., Douglas, A. J., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33002-9 · Cited by 187 · see citing works
Miklós, I. H., & Kovács, K. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00147-1 · Cited by 182 · see citing works
Suneja, S. K., Potashner, S. J., & Benson, C. G. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6812 · Cited by 173 · see citing works
Costorage and coexistence of neuropeptides in the mammalian CNS
Merighi, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00031-4 · Cited by 158 · see citing works
Chronic stress‐induced neurotransmitter plasticity in the PVN
Flak, J. N., Ostrander, M. M., Tasker, J. G., & Herman, J. P. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22142 · Cited by 140 · see citing works
NO inhibits supraoptic oxytocin and vasopressin neurons via activation of GABAergic synaptic inputs
Stern, J. E., & Ludwig, M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1815 · Cited by 139 · see citing works
Brussaard, A. B., Dévay, P., Leyting-Vermeulen, J. W., & Kits, K. S. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0513v.x · Cited by 131 · see citing works
Stern, J. E., & Armstrong, W. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-03-00841.1998 · Cited by 130 · see citing works
Immobilization stress rapidly modulates BDNF mRNA expression in the hypothalamus of adult male rats
Rage, F., Givalois, L., Marmigère, F., Tapia‐Arancibia, L., & Arancibia, S. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00072-6 · Cited by 126 · see citing works
The maternal brain: an organ with peripartal plasticity
Hillerer, K. M., Jacobs, V. R., Fischer, T., & Aigner, L. (2014) · Neural Plasticity · doi:10.1155/2014/574159 · Cited by 120 · see citing works
Jourdain, P., Israël, J.-M., Dupouy, B., Oliet, S. H. R., Michèle Allard, A., Vitiello, S., Theodosis, D. T., & Poulain, D. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06641.1998 · Cited by 118 · see citing works
Self-citationNeuroendocrine Regulation of Lactation and Milk Production
Crowley, W. R. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140029 · Cited by 124 · see citing works
Neural circuitry for maternal oxytocin release induced by infant cries
Valtcheva, S., Issa, H. A., Bair-Marshall, C. J., Martin, K. A., Jung, K., Zhang, Y., Kwon, H.-B., & Froemke, R. C. (2023) · Nature · doi:10.1038/s41586-023-06540-4 · Cited by 115 · see citing works
Lonstein, J. S., & Vries, G. J. D. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00287-6 · Cited by 111 · see citing works
Oliet, S. H. R., & Poulain, D. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00815.x · Cited by 109 · see citing works
Párducz, Á., Hajszán, T., MacLusky, N. J., Hoyk, Z., Csakvari, E., Kurunczi, A., Prange‐Kiel, J., & Leranth, C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.008 · Cited by 108 · see citing works
Oliet, S. H. R., Baimoukhametova, D. V., Piet, R., & Bains, J. S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2676-06.2007 · Cited by 107 · see citing works
Theodosis, D. T., Piet, R., Poulain, D. A., & Oliet, S. H. R. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.11.003 · Cited by 105 · see citing works
Self-citationStern, J. E., & Armstrong, W. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-04861.1996 · Cited by 104 · see citing works
Activity‐related, dynamic neuron‐glial interactions in the hypothalamo‐neurohypophysial system
Miyata, S., & Hatton, G. I. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10012 · Cited by 98 · see citing works
Glial modulation of synaptic transmission: Insights from the supraoptic nucleus of the hypothalamus
Oliet, S. H. R., Piet, R., Poulain, D. A., & Theodosis, D. T. (2004) · Glia · doi:10.1002/glia.20032 · Cited by 98 · see citing works
Self-citationPeptidomic Identification and Biological Validation of Neuroendocrine Regulatory Peptide-1 and -2
Yamaguchi, H., Sasaki, K., Satomi, Y., Shimbara, T., Kageyama, H., Mondal, M. S., Toshinai, K., Date, Y., González, L. J., Shioda, S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701665200 · Cited by 94 · see citing works
Di, S., & Tasker, J. G. (2004) · Endocrinology · doi:10.1210/en.2004-0702 · Cited by 87 · see citing works
Majdoubi, M. E., Poulain, D. A., & Theodosis, D. T. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01600.x · Cited by 86 · see citing works
Self-citationMajdoubi, M. E., Poulain, D. A., & Theodosis, D. T. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00193-0 · Cited by 86 · see citing works
Self-citationFénelon, V. S., & Herbison, A. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-04872.1996 · Cited by 83 · see citing works
GABA‐induced facilitation of the periodic bursting activity of oxytocin neurones in suckled rats.
Moos, F. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020949 · Cited by 79 · see citing works
Theodosis, D. T., Trailin, A., & Poulain, D. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00755.2005 · Cited by 77 · see citing works
Self-citationWigger, A., & Neumann, I. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00068-4 · Cited by 74 · see citing works
Melloni, R. H., & Ricci, L. A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.11.002 · Cited by 72 · see citing works
Factors Governing Activity-Dependent Structural Plasticity of the Hypothalamoneurohypophysial System
Theodosis, D. T., Majdoubi, M. E., Pierre, K., & Poulain, D. A. (1998) · Cellular and Molecular Neurobiology · doi:10.1023/a:1022577105819 · Cited by 69 · see citing works
Self-citationStern, J. E., Hestrin, S., & Armstrong, W. E. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00109.x · Cited by 68 · see citing works
Somato‐dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation
Brown, C. H., Ludwig, M., Tasker, J. G., & Stern, J. E. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12856 · Cited by 65 · see citing works
Changes in the Active Membrane Properties of Rat Supraoptic Neurones During Pregnancy and Lactation
Teruyama, R., & Armstrong, W. E. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00844.x · Cited by 66 · see citing works
The role of astrocytes in the hypothalamic response and adaptation to metabolic signals
Chowen, J. A., Argente-Arizón, P., Freire‐Regatillo, A., Frago, L. M., Horváth, T. L., & Argente, J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.001 · Cited by 63 · see citing works
Romanski, L. M., Giguere, M., Bates, J. F., & Goldman-Rakic, P. S. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970317)379:3 · Cited by 325 · see citing works
Self-citationLin, S., Miyata, S., Matsunaga, W., Kawarabayashi, T., Nakashima, T., & Kiyohara, T. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01484-4 · Cited by 62 · see citing works
Voisin, D. L., Herbison, A. E., & Poulain, D. A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020579 · Cited by 63 · see citing works
Theodosis, D. T., Koksma, J.-J., Trailin, A., Langle, S. L., Piet, R., Lodder, J. C., Timmerman, J. A., Mansvelder, H., Poulain, D., Oliet, S., et al. (2006) · Molecular and cellular neurosciences · doi:10.1016/j.mcn.2006.01.006 · Cited by 65 · see citing works
Self-citationNeurophysiological and cognitive changes in pregnancy
Grattan, D. R., & Ladyman, S. R. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00002-3 · Cited by 63 · see citing works
Teruyama, R., & Armstrong, W. E. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.085985 · Cited by 59 · see citing works
Bertozzi, G., Sessa, F., Albano, G. D., Sani, G., Maglietta, F., Roshan, M. H. K., Volti, G. L., Bernardini, R., Avola, R., Pomara, C., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0774-1 · Cited by 58 · see citing works
Oxytocin receptor binding in the hypothalamus during gestation in rats
Bealer, S. L., Lipschitz, D. L., Ramoz, G., & Crowley, W. R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00766.2005 · Cited by 54 · see citing works
Chapter 3 Maternity leads to morphological synaptic plasticity in the oxytocin system
Theodosis, D. T., & Poulain, D. A. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33004-2 · Cited by 56 · see citing works
Self-citationContribution of Astrocytes to Activity-Dependent Structural Plasticity in the Adult Brain
Theodosis, D. T., & Poulain, D. A. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4685-6_14 · Cited by 55 · see citing works
Self-citationMouginot, D., Kombian, S. B., & Pittman, Q. J. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.3.1508 · Cited by 52 · see citing works
Vargas-Martínez, F., Uvnás-Moberg, K., Petersson, M., Olausson, H., & Jiménez-Estrada, I. (2014) · Progress in neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 49 · see citing works
Visualization of local afferent inputs to magnocellular oxytocin neurons in vitro
Jourdain, P., Dupouy, B., Bonhomme, R., Poulain, D. A., Israël, J.-M., & Theodosis, D. T. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00620.x · Cited by 50 · see citing works
Self-citationWang, Y., Shibuya, I., Kabashima, N., Setiadji, V. S., Isse, T., Ueta, Y., & Yamashita, H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00732-x · Cited by 48 · see citing works
Azdad, K., Piet, R., Poulain, D. A., & Oliet, S. H. R. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00226.2003 · Cited by 47 · see citing works
Ricci, L. A., Schwartzer, J. J., & Melloni, R. H. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.10.011 · Cited by 43 · see citing works
Langle, S. L., Poulain, D. A., & Theodosis, D. T. (2002) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(02)00003-7 · Cited by 45 · see citing works
Self-citationHadley, S. D., Walker, P. D., & Goshgarian, H. G. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7238 · Cited by 42 · see citing works
Adhesion molecules and structural plasticity of the adult hypothalamo-neurohypophysial system
Theodosis, D. T., Bonfanti, L., Olive, S., Rougon, G. N., & Poulain, D. A. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90032-9 · Cited by 42 · see citing works
Self-citationChapter 9 Functional synaptic plasticity in hypothalamic magnocellular neurons
Tasker, J. G., Di, S., & Boudaba, C. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39011-3 · Cited by 41 · see citing works
Hussy, N. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39010-1 · Cited by 40 · see citing works
Immunolocalization of glutathione reductase in the murine brain
Knollema, S., Hom, H. W., Schirmer, H., Korf, J., & Horst, G. J. T. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960916)373:2 · Cited by 27 · see citing works
Glia-Dependent Switch of Kainate Receptor Presynaptic Action
Bonfardin, V. D. J., Fossat, P., Theodosis, D. T., & Oliet, S. H. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3389-09.2010 · Cited by 39 · see citing works
Self-citationModulation of GABAergic transmission by endogenous glutamate in the rat supraoptic nucleus
Piet, R., Bonhomme, R., Theodosis, D. T., Poulain, D. A., & Oliet, S. H. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02611.x · Cited by 38 · see citing works
Self-citationIntegrative neurohumoural regulation of oxytocin neurone activity in pregnancy and lactation
Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12569 · Cited by 36 · see citing works
Fénelon, V. S., & Herbison, A. E. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00130-k · Cited by 37 · see citing works
Polston, E. K., Heitz, M., Barnes, W., Cardamone, K., & Erskine, M. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04104.2001 · Cited by 36 · see citing works
Majdoubi, M. E., Poulain, D. A., & Theodosis, D. T. (2000) · Biochemistry and Cell Biology · doi:10.1139/o00-023 · Cited by 35 · see citing works
Self-citationNeuroendocrine Regulation of Lactation and Milk Production
Crowley, W. R. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00607.x · Cited by 34 · see citing works
Electrophysiological Distinctions Between Oxytocin and Vasopressin Neurons in the Supraoptic Nucleus
Armstrong, W. E., & Stern, J. E. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_7 · Cited by 34 · see citing works
Schwartzer, J. J., Ricci, L. A., & Melloni, R. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.007 · Cited by 33 · see citing works
Fénelon, V. S., Theodosis, D. T., & Poulain, D. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)90809-5 · Cited by 33 · see citing works
Self-citationVoisin, D. L., Chapman, C., Poulain, D. A., & Herbison, A. E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90549-5 · Cited by 33 · see citing works
Monlezun, S., Ouali‐Hassenaoui, S., Poulain, D. A., & Theodosis, D. T. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.04.003 · Cited by 31 · see citing works
Self-citationStructural and Functional Plasticity in the Maternal Brain Circuitry
Pereira, M. (2016) · New Directions for Child and Adolescent Development · doi:10.1002/cad.20163 · Cited by 30 · see citing works
Taurine selectively modulates the secretory activity of vasopressin neurons in conscious rats
Engelmann, M., Ludwig, M., Singewald, N., Ebner, K., Sabatier, N., Lübec, G., Landgraf, R., & Wotjak, C. T. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01729.x · Cited by 30 · see citing works
Synchronized bursts of miniature inhibitory postsynaptic currents
Popescu, I., Morton, L. A., Franco, A. J., Di, S., Ueta, Y., & Tasker, J. G. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181461 · Cited by 28 · see citing works
Schwartzer, J. J., & Melloni, R. H. (2010) · Behavioral Neuroscience · doi:10.1037/a0020899 · Cited by 28 · see citing works
Armstrong, W. E., & Stern, J. E. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61564-2 · Cited by 28 · see citing works
Kornblatt, J. J., & Grattan, D. R. (2001) · Neuroendocrinology · doi:10.1159/000054634 · Cited by 27 · see citing works
Contribution of astrocytes to synaptic transmission in the rat supraoptic nucleus
Piet, R., Poulain, D. A., & Oliet, S. H. R. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.07.005 · Cited by 25 · see citing works
Sharman, G., Ghorbel, M. T., Leroux, M., Beaucourt, S. M., Wong, L., & Murphy, D. (2004) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2003.11.005 · Cited by 24 · see citing works
GABA enhancement of maternal defense in mice: Possible neural correlates
Lee, G., & Gammie, S. C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.023 · Cited by 23 · see citing works
Modulation of synaptic transmission by astrocytes in the rat supraoptic nucleus.
Piet, R., Poulain, D., & Oliet, S. (2002) · Journal of Physiology - Paris · doi:10.1016/s0928-4257(02)00010-4 · Cited by 25 · see citing works
Prolactin enhances hippocampal synaptic plasticity in female mice of reproductive age
Zamora‐Moratalla, A., & Martín, E. D. (2020) · Hippocampus · doi:10.1002/hipo.23288 · Cited by 21 · see citing works
Ibrahim, N., Shibuya, I., Kabashima, Sutarmo, Ueta, & Yamashita (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00404.x · Cited by 22 · see citing works
Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior
Kato, Y., Katsumata, H., Inutsuka, A., Yamanaka, A., Onaka, T., Minami, S., & Orikasa, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-82773-5 · Cited by 19 · see citing works
Neurochemical bases of plasticity in the magnocellular oxytocin system during gestation
Lipschitz, D. L., Crowley, W. R., Armstrong, W. E., & Bealer, S. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.003 · Cited by 18 · see citing works
Mueller, N. K., Di, S., Paden, C. M., & Herman, J. P. (2004) · Endocrinology · doi:10.1210/en.2004-0539 · Cited by 18 · see citing works
Leng, T., Leng, G., & MacGregor, D. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180368 · Cited by 17 · see citing works
Wuarin, J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.6.3180 · Cited by 16 · see citing works
Plasticity in the electrophysiological properties of oxytocin neurons
Armstrong, W. E., Stern, J. E., & Teruyama, R. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10019 · Cited by 15 · see citing works
Kumar, S., Parkash, J., Kataria, H., & Kaur, G. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.040 · Cited by 17 · see citing works
Tonic Regulation of GABAergic Synaptic Activity on Vasopressin Neurones by Cannabinoids
Wang, L., & Armstrong, W. E. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02239.x · Cited by 13 · see citing works
- Authors
- Gies, U., & Theodosis, D.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-05-01
- Volume
- 14
- Issue
- 5
- Pages
- 2861-2869
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577499
- OpenAlex
- W2119677102
- Cited by
- 125
- References
- 49
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Science Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- synaptic plasticity, supraoptic nucleus, lactation, GABAergic innervation, oxytocin neurons, synaptic density, neurosecretory cells, axodendritic synapses, hypothalamus, ultrastructure
- MeSH terms
- Animals, Antibodies, Monoclonal, Axons, Dendrites, Female, gamma-Aminobutyric Acid, Lactation, Nerve Endings, Neuronal Plasticity, Neurons, Oxytocin, Pregnancy, Supraoptic Nucleus, Synapses, Microscopy, Immunoelectron, Rats, Wistar, Rats
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