Acetylcholinesterase in the human frontal associative cortex during the period of cognitive development: early laminar shifts and late innervation of pyramidal neurons
Abstract
Laminar preferences in fibrillar acetylcholinesterase (AChE) staining change dramatically in the human frontal cortex during the first postnatal year and perikaryal reactivity is found only in non-pyramidal neurons. The AChE reactivity of layer III pyramidal cell bodies and surrounding fibrillar network begins to develop after the first postnatal year, increases gradually and reaches its peak intensity in young adults, displaying a cluster-like arrangement. These data suggest that AChE-rich elements participate in the innervation of cortical associative neurons and layers during the cognitive development in man.
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Within the PFC, the cholinergic innervation initially terminates in layers III and IV, slowly losing laminar preference over time.
“Within the PFC, the cholinergic innervation initially terminates in layers III and IV slowly losing laminar preference over time [221–223].”
From Development of prefrontal cortex (2022) · cites this paper as [222]
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- Authors
- Kostović, I., Škavić, J., & Strinović, D.
- Affiliations
- University of Zagreb (HR)
- Corresponding author
- Kostović, Ivica
- ORCID
- Kostović, Ivica
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1988-07
- Volume
- 90
- Issue
- 1-2
- Pages
- 107-112
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2074767505
- Cited by
- 58
- References
- 23
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 2 · 2018: 2 · 2015: 1 · 2013: 1 · 2012: 3
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- acetylcholinesterase, frontal cortex, cognitive development, pyramidal neurons, cortical layers, laminar organization, postnatal development, cholinergic innervation, non-pyramidal neurons, human brain
- MeSH terms
- Acetylcholinesterase, Adolescent, Adult, Child, Child, Preschool, Cognition, Frontal Lobe, Gestational Age, Histocytochemistry, Humans, Infant, Infant, Newborn, Infant, Premature
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