Development of axonal pathways in the human fetal fronto-limbic brain: histochemical characterization and diffusion tensor imaging
Open accessAbstract
The development of cortical axonal pathways in the human brain begins during the transition between the embryonic and fetal period, happens in a series of sequential events, and leads to the establishment of major long trajectories by the neonatal period. We have correlated histochemical markers (acetylcholinesterase (AChE) histochemistry, antibody against synaptic protein SNAP-25 (SNAP-25-immunoreactivity) and neurofilament 200) with the diffusion tensor imaging (DTI) database in order to make a reconstruction of the origin, growth pattern and termination of the pathways in the period between 8 and 34 postconceptual weeks (PCW). Histological sections revealed that the initial outgrowth and formation of joined trajectories of subcortico-frontal pathways (external capsule, cerebral stalk-internal capsule) and limbic bundles (fornix, stria terminalis, amygdaloid radiation) occur by 10 PCW. As early as 11 PCW, major afferent fibers invade the corticostriatal junction. At 13-14 PCW, axonal pathways from the thalamus and basal forebrain approach the deep moiety of the cortical plate, causing the first lamination. The period between 15 and 18 PCW is dominated by elaboration of the periventricular crossroads, sagittal strata and spread of fibers in the subplate and marginal zone. Tracing of fibers in the subplate with DTI is unsuccessful due to the isotropy of this zone. Penetration of the cortical plate occurs after 24-26 PCW. In conclusion, frontal axonal pathways form the periven…
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The results of fetal tractography are consistent with classical histological studies.
“These results are consistent with classical histological studies (Mitter et al., 2015; Vasung et al., 2010).”
From Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review (2022) · cites this paper as Vasung et al., 2010
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- Authors
- Vasung, L., Huang, H., Jovanov‐Milošević, N., Pletikos, M., Mori, S., & Kostović, I.
- Affiliations
- University of Zagreb (HR)
- Johns Hopkins University (US)
- Corresponding author
- Vasung, Lana
- Venue
- Journal of Anatomy
- Publisher
- Wiley
- Published
- 2010-09-08
- Volume
- 217
- Issue
- 4
- Pages
- 400-417
- ISSN
- 0021-8782 (ISSN-L)
- 1469-7580
- PMC
- PMC2992416
- OpenAlex
- W1599456382
- Cited by
- 169
- References
- 8
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 11 · 2022: 16 · 2021: 16 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 11 · 2014: 19 · 2013: 8 · 2012: 11
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Anatomy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- human fetal brain, frontal lobe, limbic system, subcortical white matter, acetylcholinesterase histochemistry, SNAP-25, neurofilament 200, diffusion tensor imaging, fornix, stria terminalis, corticostriatal pathway, basal forebrain, cortical plate, subplate
- MeSH terms
- Acetylcholinesterase, Axons, Cerebral Cortex, Histocytochemistry, Humans, Neural Pathways, Thalamus, Neurofilament Proteins, Fetal Development, Synaptosomal-Associated Protein 25, Diffusion Tensor Imaging
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