Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort
Open accessAbstract
Research on the relation between diabetes mellitus and dementia has produced conflicting results, and the relation has not been investigated among Blacks and Hispanics. In this study, Cox proportional hazards models were used to analyze longitudinal data from 1,262 elderly subjects without dementia at baseline (1991-1996) who were followed for an average of 4.3 years between 1992 and 1997. Outcomes were incident Alzheimer's disease and dementia associated with stroke. The prevalence of diabetes was 20% at baseline. The adjusted relative risk of Alzheimer's disease among persons with diabetes as compared with those without diabetes was 1.3 (95% confidence interval (CI): 0.8, 1.9). The adjusted relative risk for the composite outcome of Alzheimer's disease and cognitive impairment without dementia (without stroke) in subjects with diabetes was 1.6 (95% CI: 1.2, 2.1). The adjusted relative risk of stroke-associated dementia in persons with diabetes was 3.4 (95% CI: 1.7, 6.9). Among Blacks and Hispanics, approximately one third of the risk of stroke-associated dementia was attributable to diabetes (33% (95% CI: 31, 36) and 36% (95% CI: 33, 37), respectively), as compared with 17% (95% CI: 13, 22) among Whites. The finding of an association between diabetes and the composite outcome of Alzheimer's disease and cognitive impairment without dementia (without stroke) is consistent with prior reports of a modest relation between diabetes and Alzheimer's disease.
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Recent studies show that, similar to Western countries, Alzheimer disease is the leading cause of dementia in Asian populations.
“Recent studies have shown that similar to Western countries, Alzheimer disease is the leading cause of dementia in Asian populations.275”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [275]
The Results (p. 3) report that Alzheimer’s disease accounted for most dementia cases in this US cohort, supporting the Western comparison. The paper does not report whether it is the leading cause of dementia in Asian populations, which is the claim’s central point. (LLM, conf=0.82)
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Self-citation
- Authors
- Luchsinger, J. A.
- Affiliations
- Columbia University (US)
- Corresponding author
- Luchsinger, J. A.
- ORCID
- Luchsinger, J. A.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-10-01
- Volume
- 154
- Issue
- 7
- Pages
- 635-641
- ISSN
- 0002-9262 (ISSN-L)
- OpenAlex
- W2088642279
- Cited by
- 682
- References
- 52
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 11 · 2023: 14 · 2022: 15 · 2021: 19 · 2020: 28 · 2019: 24 · 2018: 25 · 2017: 36 · 2016: 33 · 2015: 32 · 2014: 45 · 2013: 39 · 2012: 39
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute on Aging (AG08702, P01AG007232, AG 07232, P50AG008702)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- diabetes mellitus, Alzheimer's disease, cognitive impairment, dementia risk, racial and ethnic differences, Black and Hispanic populations, older adults, multi-ethnic cohort
- MeSH terms
- Aged, Alzheimer Disease, Black or African American, Diabetes Mellitus, Female, Hispanic or Latino, Humans, Longitudinal Studies, Male, New York City, Risk Factors, Dementia, Vascular, Proportional Hazards Models, Stroke, Black People, Diabetes Complications
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