ApoE immunoreactivity and microglial cells in Alzheimer’s disease brain
Abstract
The spatial relationship of apolipoprotein E (apoE)-like immunoreactivity (IR) to amyloid beta-peptide (A beta), astrocytes and microglial cells in the brain of Alzheimer's disease was studied by double immunolabelling. Diffuse apoE-like IR was seen in A beta diffuse deposits, and markedly increased in the core of classic senile plaques. Microglial cells, sometimes immunoreactive for apoE, were frequent in areas of apoE-like IR, where they often grouped into clusters in the core of apoE-labelled senile plaques. Although astrocytic processes were seen within these senile plaques, the cell bodies were always at a distance from the core. None of these astrocytes expressed apoE-like IR. Microglial cells, some of them immunoreactive for apoE, were seen in the center of apoE-labelled senile plaques. These data suggest that microglial cells play a more significant role than astrocytes in apoE deposition in senile plaques of Alzheimer disease.
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In a normal brain, apoE is produced predominantly by astrocytes, and to a much less extent by microglia.
“In a normal brain, apoE is produced predominantly by astrocytes, and to a much less extent, by microglia (Boyles et al., 1985; Uchihara et al., 1995).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Uchihara et al., 1995
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- Authors
- Uchihara, T., Duyckaerts, C., He, Y., Kobayashi, K., Seilhean, D., Amouyel, P., & Hauw, J.-J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Hauw, Jean-Jacques
- ORCID
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 195
- Issue
- 1
- Pages
- 5-8
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2084420686
- Cited by
- 131
- References
- 4
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 13 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3 · 2013: 3 · 2012: 2
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- apolipoprotein E, microglial cells, Alzheimer's disease, amyloid plaques, amyloid-beta, astrocytes, neuroinflammation
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Astrocytes, Cerebral Infarction, Humans, Immunohistochemistry, Amyloid beta-Peptides, Microglia
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