Amyloid β-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation
Abstract
The neuropathological hallmarks of Alzheimer's disease (AD) are amyloid-containing plaques and neurofibrillary tangles. The main constituent of senile plaques is amyloid beta-peptide (A beta) and in recent years, pathogenic mutations in the amyloid precursor protein (APP) gene have been discovered in some AD families. The APP670/671 mutation, found in a Swedish AD family, has revealed over-production of A beta as one pathogenic mechanism for the development of AD. In the present study we have used an immunoassay to measure A beta levels in cerebrospinal fluid (CSF) from APP670/671 mutation-carriers and non-carriers. A correlation was seen between decrease in A beta levels and duration of disease although no difference was found in levels of A beta between the groups (14.5 +/- 3.3 ng/ml versus 14.9 +/- 2.3 ng/ml).
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- Authors
- Lannfelt, L., Basun, H., Vigo-Pelfrey, C., Wahlund, L.-O., Winblad, B., Lieberburg, I., & Schenk, D.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Lannfelt, Lars
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 199
- Issue
- 3
- Pages
- 203-206
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2010245335
- Cited by
- 39
- References
- 27
- Citations by year
- 2022: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, cerebrospinal fluid, Alzheimer's disease, amyloid plaques, disease duration, cerebrospinal fluid biomarkers
- MeSH terms
- Adult, Aged, Alzheimer Disease, Family, Genotype, Humans, Middle Aged, Mutation, Sweden, Time Factors, Amyloid beta-Protein Precursor
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