Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain
Abstract
We investigated whether psychotropics orally administered to rats affect levels of interleukin-1 beta (IL-1 beta) and interleukin-1 receptor antagonist (IL-1Ra) mRNA in the hypothalamus, hippocampus, frontal cortex, and brain stem, using a reverse transcription-polymerase chain reaction method. The psychotropics tested were chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, and diazepam. Treatment for 28 days raised the levels of both mRNAs. The increase in IL-1Ra mRNA was 6-112 times larger than that of IL-1 beta mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1Ra mRNA than IL-1 beta mRNA in the brain.
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An in vitro study reported anti-inflammatory reactions with therapeutic doses of antidepressants that involved the inhibition of IFN-γ and increased IL-10.
“An in vitro study reported anti-inflammatory reactions with therapeutic doses of antidepressants that involved the inhibition of IFN-γ and increased IL-10[31].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [31]
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- Authors
- Suzuki, E., Shintani, F., Kanba, S., Asai, M., & Nakaki, T.
- Affiliations
- Keio University (JP)
- Corresponding author
- Suzuki, Eiji
- ORCID
- Suzuki, Eiji
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 215
- Issue
- 3
- Pages
- 201-204
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1970183986
- Cited by
- 55
- References
- 21
- Citations by year
- 2021: 1 · 2017: 1 · 2016: 2 · 2012: 2
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- IL-1β, interleukin-1 receptor antagonist, psychotropic drugs, chronic drug administration, mRNA expression, hypothalamus, hippocampus, frontal cortex, brainstem, chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, diazepam, neuroinflammation
- MeSH terms
- Animals, Brain, Chlorpromazine, Haloperidol, Male, Psychotropic Drugs, RNA, Messenger, Time Factors, Rats, Sprague-Dawley, Receptors, Interleukin-1, Rats
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