Cited by 55Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

Suzuki, Eiji, Shintani, Futoshi, Kanba, Shigenobu, Asai, Masahiro, Nakaki, Toshio·1996·Neuroscience Letters

Abstract

We investigated whether psychotropics orally administered to rats affect levels of interleukin-1 beta (IL-1 beta) and interleukin-1 receptor antagonist (IL-1Ra) mRNA in the hypothalamus, hippocampus, frontal cortex, and brain stem, using a reverse transcription-polymerase chain reaction method. The psychotropics tested were chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, and diazepam. Treatment for 28 days raised the levels of both mRNAs. The increase in IL-1Ra mRNA was 6-112 times larger than that of IL-1 beta mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1Ra mRNA than IL-1 beta mRNA in the brain.

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Crossref · 10.1016/0304-3940(96)12985-2

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Authors
Suzuki, E., Shintani, F., Kanba, S., Asai, M., & Nakaki, T.
Affiliations
Keio University (JP)
Corresponding author
Suzuki, Eiji
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1996-09
Volume
215
Issue
3
Pages
201-204
ISSN
0304-3940 (ISSN-L)
OpenAlex
W1970183986
Cited by
55
References
21
Citations by year
2021: 1 · 2017: 1 · 2016: 2 · 2012: 2
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
IL-1β, interleukin-1 receptor antagonist, psychotropic drugs, chronic drug administration, mRNA expression, hypothalamus, hippocampus, frontal cortex, brainstem, chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, diazepam, neuroinflammation
MeSH terms
Animals, Brain, Chlorpromazine, Haloperidol, Male, Psychotropic Drugs, RNA, Messenger, Time Factors, Rats, Sprague-Dawley, Receptors, Interleukin-1, Rats

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