Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1β in the rat
Abstract
Rationale The hypothesis that proinflammatory cytokines play a causative role in the pathophysiology of depression has been recently tested by studying the effect of antidepressants on production of endogenous cytokines, and on sickness behavior induced by exogenous cytokines. In this last case, however, the effect of antidepressants has been only studied on the effect of peripherally administered cytokines. Objectives The aim of the present study was to determine whether the antidepressant tianeptine can attenuate both peripheral and central cytokine actions. Methods Rats were injected IP with acute (10 mg/kg) or chronic (10 mg/kg, 2 times/day, 17 days) tianeptine. The effects of this treatment were assessed on the behavioral (social exploration, locomotion) and metabolic (food intake, body weight) alterations induced by peripheral or central administration of the cytokine inducer lipopolysaccharide (LPS) (250 microg/kg IP; 100 ng/rat ICV) or the prototypical proinflammatory cytokine interleukin-1 (IL-1)beta (15 microg/rat IP; 90 ng/rat ICV). Results Chronic, but not acute, treatment with tianeptine attenuated the behavioral signs of sickness behavior induced by peripheral, but not central, LPS or IL-1beta. Conclusions This work, which is the first in vivo study assessing the effect of an antidepressant on centrally induced immune activation, shows a clear dissociation between peripheral and central cytokine effects, and suggests a peripheral site of action of tianeptine. It…
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Depressive-like behaviors evoked by bacterial endotoxin administration can be alleviated by antidepressant medication or eliminated almost entirely by pretreatment with cytokine synthesis blockers or cytokine antagonists.
“depressive-like behaviors that are evoked by bacterial endotoxin administration can be alleviated by antidepressant medication administration or eliminated almost entirely by pretreatment with cytokine synthesis blockers or cytokine antagonists”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Castanon, Bluthé, & Dantzer, 2001
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- Authors
- Castanon, N., Bluthé, R.-M., & Dantzer, R.
- Affiliations
- Inserm (FR)
- Venue
- Psychopharmacology
- Published
- 2001-02-22
- Volume
- 154
- Issue
- 1
- Pages
- 50-60
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2085264188
- Cited by
- 136
- References
- 4
- Citations by year
- 2025: 2 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 10
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Recherche Agronomique
- Institut de Recherches Servier
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- tianeptine, atypical antidepressants, sickness behavior, lipopolysaccharide, IL-1β, inflammatory cytokines, depression, dietary intake, locomotion, social exploration, body weight
- MeSH terms
- Animals, Antidepressive Agents, Tricyclic, Behavior, Animal, Endotoxins, Exploratory Behavior, Immune System, Injections, Intraperitoneal, Injections, Intraventricular, Interleukin-1, Lipopolysaccharides, Male, Motor Activity, Social Behavior, Thiazepines, Weight Loss, Rats, Wistar, Rats
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