The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions
Abstract
This study examined the hypothesis that descending inhibitory pathways from brain stem to spinal cord mediate the analgesic effect of both electrical brain stimulation and morphine. In the first set of experiments, the effect of subtotal midthoracic spinal cord lesions on the analgesic effect of electrical stimulation in the periaqueductal gray matter of the rat was examined. In the second, the effect of similar cord lesions on the analgesic effect of intraperitoneal morphine was studied. In both cases, a lesion of the dorsal part of the lateral funiculus (DLF) reduced or abolished the analgesia of the hindlimbs. Analgesia of the forelimbs was unaffected. Lesions of the dorsal columns, which include the corticospinal tract, or lesions of the ventral part of the lateral funiculus had no effect on analgesia. It is concluded that an inhibitory pathway, which descends in the dorsal part of the lateral funiculus and which probably originates in the nucleus raphe magnus of the medulla, mediates the descending control found in both morphine and stimulus-produced analgesia.
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Cites
The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem
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Opiate Receptor: Demonstration in Nervous Tissue
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Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
Reynolds, D. V. (1969) · Science · doi:10.1126/science.164.3878.444 · Cited by 1,389
Dahlstroem, A., & Fuxé, K. (1965) · PubMed · Cited by 1,015
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Analgesia Mediated by a Direct Spinal Action of Narcotics
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Analgesia from Electrical Stimulation in the Brainstem of the Rat
Mayer, D. J., Wolfle, T. L., Akil, H., Carder, B., & Liebeskind, J. C. (1971) · Science · doi:10.1126/science.174.4016.1351 · Cited by 772
Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis
Mayer, D. J., & Liebeskind, J. C. (1974) · Brain Research · doi:10.1016/0006-8993(74)90534-4 · Cited by 719
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Cited by
Organization of endogenous opiate and nonopiate pain control systems
Watkins, L. R., & Mayer, D. J. (1982) · Science · doi:10.1126/science.6281891 · Cited by 791
Presley, R., Menetrey, D., Levine, J., & Basbaum, A. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00323.1990 · Cited by 527
Self-citationSerotonin-containing neurons: their possible role in pain and analgesia
Messing, R. B., & Lytle, L. D. (1977) · Pain · doi:10.1016/0304-3959(77)90083-5 · Cited by 398
Metadata
- Authors
- Basbaum, A. I., Marley, N. J. E., OʼKeefe, J., & Clanton, C. H.
- Venue
- Pain
- Published
- 1977-02
- Volume
- 3
- Issue
- 1
- Pages
- 43-56
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W1981568012
- Cited by
- 310
- References
- 31
- FWCI
- 28.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
