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Cited by 421Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsSystemic Sclerosis and Related Diseases

Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis

Vaerøy, Henning, Helle, Robert, Førre, Øystein, Kåss, Erik, Terenius, Lars·1988·Pain
DOI 10.1016/0304-3959(88)90019-x
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Abstract

In 30 patients with diagnosed fibromyalgia, the CSF level of immunoreactive substance P (SP) was investigated. Compared to normal values (9.6 +/- 3.2 fmol/ml), all the patients had elevated CSF levels of SP (36.1 +/- 2.7 fmol/ml, range 16.5-79.1 fmol/ml). Anamnestic information from the patients revealed that 53.3% had Raynaud/Raynaud-like phenomenon localized in the fingers, the toes or both. Although SP levels did not differ significantly in patients with or without the Raynaud phenomenon, elevated activity may be present in the peripheral branches of SP neurons which could be responsible for the last (rubor) phase of the triphasic Raynaud's phenomenon. SP levels were significantly higher in patients who were smokers (40.1 +/- 2.7 fmol/ml, range 25.3-64.1 fmol/ml), compared to patients who were non-smokers (29.2 +/- 5.0 fmol/ml, range 16.5-79.1 fmol/ml). We propose elevated CSF levels of SP and the Raynaud phenomenon as characteristic features for fibromyalgia with potential as diagnostic markers of the disease and further that smoking might be an aggravating factor for its pathogenesis or development.

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  • In a clinical trial involving 30 female patients with fibromyalgia, increased secretion of substance P in the cerebrospinal fluid was observed in all fibromyalgia patients.

    “In a clinical trial involving 30 female patients with FMS, increased secretion level of SP in the cerebrospinal fluid (CSF) was observed in the cerebrospinal fluid (CSF) of all the FMS patients (50).”

    From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [50]

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Authors
Vaerøy, H., Helle, R., Førre, Ø., Kåss, E., & Terenius, L.
Affiliations
  • University of Oslo (NO)
  • Uppsala University (SE)
Corresponding author
  • Helle, Robert
  • Førre, Øystein
  • Kåss, Erik
  • Terenius, Lars
ORCID
Terenius, Lars
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1988-01
Volume
32
Issue
1
Pages
21-26
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/0304-3959(88)90019-x
OpenAlex
W1988031794
Cited by
421
References
1
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 11 · 2012: 7
FWCI
7.48
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
Keywords
fibromyalgia, substance P, cerebrospinal fluid, Raynaud's phenomenon, smoking, diagnostic biomarkers, peripheral sensory neurons, pathogenesis
MeSH terms
Adult, Female, Fibromyalgia, Humans, Raynaud Disease, Smoking, Substance P

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