Dermal IgG Deposits and Increase of Mast Cells in Patients with Fibromyalgia - Relevant Findings or Epiphenomena?

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310302 · Cited by 19,753 · see citing works

The american college of rheumatology 1990 criteria for the classification of fibromyalgia

Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563 · see citing works

Revised Criteria for the Classification of Rheumatoid Arthritis

Arnett, F. C. (1990) · Orthopaedic Nursing · doi:10.1097/00006416-199003000-00011 · Cited by 7,742 · see citing works

Histology for Pathologists

(1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-3-272_3 · Cited by 802 · see citing works

Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects

Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539 · see citing works

Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis

Vaerøy, H., Helle, R., Førre, Ø., Kåss, E., & Terenius, L. (1988) · Pain · doi:10.1016/0304-3959(88)90019-x · Cited by 421 · see citing works

Histology for Pathologists

Weiland, T. L., & Gaffey, T. A. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62290-3 · Cited by 370 · see citing works

Structure‐activity relationships for some substance P‐related peptides that cause wheal and flare reactions in human skin.

Foreman, J. C., Jordan, C., OEHME, P., & Renner, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014543 · Cited by 311 · see citing works

Pain Analysis in Patients with Fibromyalgia:Effects of intravenous morphine, lidocaine, and ketamine

Sörensen, J., Bengtsso, A., Backman, E. J., Henriksson, K. G., & Bengtsson, M. (1995) · Scandinavian Journal of Rheumatology · doi:10.3109/03009749509095181 · Cited by 246 · see citing works

Advances in Pain Research and Therapy.

Berde, C. B. (1990) · Clinical Journal of Pain · doi:10.1097/00002508-199006000-00025 · Cited by 178 · see citing works

Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery

Skofitsch, G., Savitt, J. M., & Jacobowitz, D. M. (1985) · Histochemistry and Cell Biology · doi:10.1007/bf00502084 · Cited by 154 · see citing works

Untitled work

(1987) · PubMed · Cited by 101 · see citing works

A comparative study of clinical signs in fibromyalgia/fibrositis syndrome, healthy and exercising subjects.

Granges, G., & Littlejohn, G. O. (1993) · PubMed · Cited by 81 · see citing works

Immunofluorescent detection of igg at the dermal‐epidermal junction in patients with apparent primary fibrositis syndrome

Caro, X. J. (1984) · Arthritis & Rheumatism · doi:10.1002/art.1780271014 · Cited by 53 · see citing works

Fibromyalgia and Myofascial Pain Syndrome

Starlanyl, D. J. (1996) · Clinical Bulletin of Myofascial Therapy · doi:10.1300/j425v02n02_06 · Cited by 50 · see citing works

Physical medicine and rehabilitation approaches to the management of myofascial pain and fibromyalgia syndromes

Rosen, N. B. (1994) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80053-6 · Cited by 46 · see citing works

Chronic muscular pain: aetiology and pathogenesis

Henriksson, K. G. (1994) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80044-5 · Cited by 24 · see citing works

A controlled and blinded study of immunoreactant deposition at the dermal-epidermal junction of patients with primary fibrositis syndrome.

Caro, X. J., Wolfe, F., Wh, J., & Al, S. (1986) · PubMed · Cited by 22 · see citing works

Absence of autoantibodies in primary fibromyalgia.

Bengtsson, Å., Ernerudh, J., Vrethem, M., & Skogh, T. (1990) · PubMed · Cited by 17 · see citing works

Attachment of IgG to dermal extracellular matrix in patients with fibromyalgia.

Eneström, S., Bengtson, A., Lindström, F. D., & Johan, K. (1990) · PubMed · Cited by 15 · see citing works

Fibrositis/fibromyalgia syndrome: the key to the puzzle of chronic pain

Reilly, P. A., & Littlejohn, G. O. (1990) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1990.tb120913.x · Cited by 12 · see citing works

A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: Implications for a new paradigm in fibromyalgia etiopathogenesis

Grayston, R., Czanner, G., Elhadd, K., Goebel, A., Frank, B., Üçeyler, N., Malik, R. A., & Alam, U. (2019) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2018.08.003 · Cited by 213 · see citing works

The immune system in irritable bowel syndrome

Barbara, G., Cremon, C., Carini, G., Bellacosa, L., Zecchi, L., Giorgio, R. D., Corinaldesi, R., & Stanghellini, V. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.349 · Cited by 211 · see citing works

The human mast cell: functions in physiology and disease

Krishnaswamy, G. A. (2001) · Frontiers in bioscience · doi:10.2741/krishnas · Cited by 202 · see citing works

The Human Mast Cell: An Overview

Krishnaswamy, G. A., Ajitawi, O., & Chi, D. S. (2005) · Humana Press eBooks · doi:10.1385/1-59259-967-2:013 · Cited by 186 · see citing works

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

Littlejohn, G. O. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.100 · Cited by 175 · see citing works

Neurogenic inflammation in fibromyalgia

Littlejohn, G. O., & Guymer, E. K. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0672-2 · Cited by 167 · see citing works

Mast Cell-Mediated Mechanisms of Nociception

Aich, A., Afrin, L. B., & Gupta, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226151 · Cited by 156 · see citing works

Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options

Molderings, G. J., Brettner, S., Homann, J., & Afrin, L. B. (2011) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-4-10 · Cited by 149 · see citing works

Clinical manifestations and diagnosis of fibromyalgia

Bennett, R. M. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.05.009 · Cited by 138 · see citing works

Activation of human mast cells by aggregated IgG through FcγRI: additive effects of C3a

Woolhiser, M. R. (2003) · Clinical Immunology · doi:10.1016/j.clim.2003.11.007 · Cited by 114 · see citing works

High IL-13 production by human neonatal T cells: neonate immune system regulator?

Ribeiro-do-Couto, L. M., Boeije, L. C. M., Kroon, J., Hooibrink, B., Breur-Vriesendorp, B. S., Aarden, L. A., & Boog, C. J. P. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200111)31:11 · Cited by 80 · see citing works

Evidence of Abnormal Epidermal Nerve Fiber Density in Fibromyalgia: Clinical and Immunologic Implications

Caro, X. J., & Winter, E. F. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38662 · Cited by 117 · see citing works

Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients

Blanco, I., Béritze, N., Argüelles, M., Cárcaba, V., Fernández, F., Janciauskiene, S. M., Οικονομοπούλου, Κ., de Serres, F. J., Fernández-Bustillo, E., & Hollenberg, M. D. (2010) · Clinical Rheumatology · doi:10.1007/s10067-010-1474-7 · Cited by 99 · see citing works

Fibromyalgia - New Concepts of Pathogenesis and Treatment

Lucas, H., Brauch, C. M., Settas, L., & Theoharides, T. C. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/205873920601900102 · Cited by 98 · see citing works

The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines

Maes, M. H. J., Libbrecht, I., Hunsel, F. V., Lin, A., Clerck, L. S. D., Stevens, W. J., Kenis, G., Jongh, R. F. D., Bosmans, E., & Neels, H. M. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00087-0 · Cited by 96 · see citing works

Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome

Evengard, B., Nilsson, C., Lindh, G., Lindquist, L., Eneroth, P. H. E., Fredrikson, S., Terenius, L. Y., & Henriksson, K. G. (1998) · Pain · doi:10.1016/s0304-3959(98)00134-1 · Cited by 81 · see citing works

Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions

Favretti, M., Iannuccelli, C., & Franco, M. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310443 · Cited by 68 · see citing works

Status of immune mediators in fibromyalgia

Gür, A., & Oktayoğlu, P. (2008) · Current Pain and Headache Reports · doi:10.1007/s11916-008-0031-4 · Cited by 59 · see citing works

MCP-1 and IL-8 as Pain Biomarkers in Fibromyalgia: A Pilot Study

Ang, D. C., Moore, M., Hilligoss, J., & Tabbey, R. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01179.x · Cited by 56 · see citing works

The Search for Biomarkers in Fibromyalgia

Hackshaw, K. V. (2021) · Diagnostics · doi:10.3390/diagnostics11020156 · Cited by 54 · see citing works

Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.

Jones, K. D., Gelbart, T., Whisenant, T. C., Waalen, J., Mondala, T. S., Iklé, D. N., Salomon, D. R., Bennett, R. M., & Kurian, S. M. (2016) · PubMed · Cited by 49 · see citing works

Characteristic electron microscopic findings in the skin of patients with fibromyalgia—preliminary study

Kim, S. H., Kim, D. H., Oh, D.-H., & Clauw, D. J. (2007) · Clinical Rheumatology · doi:10.1007/s10067-007-0739-2 · Cited by 48 · see citing works

Characteristic electron microscopic findings in the skin of patients with fibromyalgia—preliminary study

Kim, S. H., Kim, D. H., Oh, D.-H., & Clauw, D. J. (2007) · Clinical Rheumatology · doi:10.1007/s10067-007-0807-7 · Cited by 44 · see citing works

Chronic Urticaria is Usually Associated with Fibromyalgia Syndrome

Torresani, C., Bellafiore, S., & Panfilis, G. D. (2009) · Acta Dermato Venereologica · doi:10.2340/00015555-0653 · Cited by 42 · see citing works

Mast cell activation disease and the modern epidemic of chronic inflammatory disease

Afrin, L. B. (2016) · Translational Research · doi:10.1016/j.trsl.2016.01.003 · Cited by 39 · see citing works

A heretofore undisclosed crux of Eosinophilia-Myalgia Syndrome: compromised histamine degradation

Smith, M. J., & Garrett, R. H. (2005) · Inflammation Research · doi:10.1007/s00011-005-1380-7 · Cited by 30 · see citing works

Hypersensitivity in muscle pain syndromes

Henriksson, K. G. (2003) · Current Pain and Headache Reports · doi:10.1007/s11916-003-0058-5 · Cited by 29 · see citing works

A Systematic Review and Meta-Analysis of the Prevalence of Small Fibre Impairment in Patients with Fibromyalgia

Galosi, E., Truini, A., & Stefano, G. D. (2022) · Diagnostics · doi:10.3390/diagnostics12051135 · Cited by 30 · see citing works

Dermatologic manifestations of fibromyalgia

Laniosz, V., Wetter, D. A., & Godar, D. A. (2014) · Clinical Rheumatology · doi:10.1007/s10067-014-2488-3 · Cited by 25 · see citing works

Skin biopsy findings: Implications for the pathophysiology of fibromyalgia

Kim, S.-H. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.10.057 · Cited by 25 · see citing works

Influence of tropisetron on the serum substance P levels in fibromyalgia patients

Stratz, T., Fiebich, B. L., Haus, U., & Müller, W. (2004) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740410007023 · Cited by 25 · see citing works

Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome

Vasiadi, M., Newman, J., & Theoharides, T. C. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0168-5 · Cited by 24 · see citing works

A Practical Guide for Treatment of Pain in Patients with Systemic Mast Cell Activation Disease

Molderings, G. J. (2017) · Pain Physician · doi:10.36076/ppj.20.5.e849 · Cited by 21 · see citing works

Is Fibromyalgia a Central Pain State?

Henriksson, K. G. (2002) · Journal of Musculoskeletal Pain · doi:10.1300/j094v10n01_05 · Cited by 19 · see citing works

Palpation of Muscle and Skin. Is this a Reliable and Valid Procedure in Assessment of Patients with Long-lasting Musculoskeletal Pain?

Kvåle, A., Ljunggren, A. E., & Johnsen, T. B. (2003) · Advances in Physiotherapy · doi:10.1080/14038190310016526 · Cited by 18 · see citing works

Mast Cell Stabilizer (Ketotifen) in Fibromyalgia

Ang, D. C., Hilligoss, J., & Stump, T. E. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000169 · Cited by 17 · see citing works

The evaluation of prevalence of fibromyalgia in patients with chronic urticaria

Kazanoglu, O. (2013) · Medical Science Monitor · doi:10.12659/msm.889626 · Cited by 16 · see citing works

Oxidative Stress and Chronic Inflammation as Partners in Crime in Interstitial Cystitis/Bladder Pain Syndrome

Janev, A., Zupančič, D., Veranič, P., & Kuret, T. (2025) · Journal of Innate Immunity · doi:10.1159/000546901 · Cited by 14 · see citing works

Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

Gkouvi, A., Tsiogkas, S. G., Bogdanos, D. P., Gika, H., Goulis, D. G., & Grammatikopoulou, M. G. (2024) · Current Pain and Headache Reports · doi:10.1007/s11916-024-01244-4 · Cited by 14 · see citing works

Substance P in Rheumatic Diseases

Seidel, M. F., Tsalik, J. B., Vetter, H., & Muller, W. (2007) · Current Rheumatology Reviews · doi:10.2174/157339707779815830 · Cited by 11 · see citing works

Les dosages d’IgG anti-aliments : méthodes et pertinence clinique des résultats. Position du groupe de travail de biologie de la Société française d’allergologie

Chabane, H., Doyen, V., Bienvenu, F., Adel‐Patient, K., Vitte, J., Mariotte, D., & Bienvenu, J. (2018) · Revue française d'allergologie · doi:10.1016/j.reval.2018.01.007 · Cited by 11 · see citing works

Evaluation of fibromyalgia syndrome in patients with rosacea

Acar, E. M., Erdoğan, H. K., Şaş, S., & Acer, E. (2021) · Archives of Rheumatology · doi:10.46497/archrheumatol.2021.8280 · Cited by 10 · see citing works

Cutaneous findings in fibromyalgia syndrome and their effect on quality of life

Erdoğan, H. K., Şaş, S., Acer, E., Bulur, İ., Altunay, İ. K., & Erdem, H. R. (2016) · Dermatologica Sinica · doi:10.1016/j.dsi.2016.01.006 · Cited by 10 · see citing works

Mast cells in fibromyalgia.

Pollack, S. (2015) · PubMed · Cited by 9 · see citing works

Functional somatic syndrome: how it could be relevant to rheumatologists

Masuko, K., & Nakamura, H. (2007) · Modern Rheumatology · doi:10.1007/s10165-007-0563-1 · Cited by 17 · see citing works

Fibromyalgia and Skin Disorders: A Systematic Review

D’Onghia, M., Ciaffi, J., Calabrese, L., Tognetti, L., Cinotti, É., Rubegni, P., Frediani, B., & Ursini, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154404 · Cited by 8 · see citing works

Inadequate Thyroid Hormone Regulation as the Main Mechanism of Fibromyalgia: A Review of the Evidence

Lowe, J. C., & Yellin, J. (2008) · Cited by 7 · see citing works

Research Recommendations Following the Discovery of Pain Sensitizing IgG Autoantibodies in Fibromyalgia Syndrome

Göebel, A., Andersson, D. A., Barker, C., Basu, N., Bullock, C., Bevan, S., Bashford-Rogers, R. J. M., Choy, E., Clauw, D., Dulake, D., et al. (2021) · Pain Medicine · doi:10.1093/pm/pnab338 · Cited by 7 · see citing works

Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization

Lai, W., Tang, X., Chen, S., Zhou, Y., Qi, Z., Cao, M., Yuan, C., Yu, J., & Wen, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1677310 · Cited by 4 · see citing works

Nociceptive aspects of fibromyalgia

Larson, A. A., & Kovács, K. J. (2001) · Current Pain and Headache Reports · doi:10.1007/s11916-001-0023-0 · Cited by 4 · see citing works

Fibromyalgia

Hawley, D. J., & Wolfe, F. (2000) · Elsevier eBooks · doi:10.1016/b978-012288145-9/50098-x · Cited by 3 · see citing works

Fibromyalgia syndrome—am I an autoimmune condition?

Göebel, A. (2025) · PAIN Reports · doi:10.1097/pr9.0000000000001270 · Cited by 2 · see citing works

Kronik ürtiker hastalarında fibromiyalji sendromu sıklığının değerlendirilmesi

Acar, E. M., & Şaş, S. (2022) · Ahi Evran Medical Journal · doi:10.46332/aemj.975877 · Cited by 1 · see citing works

Dermatological findings in female and male fibromyalgia patients

Kepekçi, M. (2018) · Haydarpasa Numune Training and Research Hospital Medical Journal · doi:10.14744/hnhj.2018.98705 · Cited by 1 · see citing works

Fibromyalgia Review

Bennett, R. M. (2003) · Journal of Musculoskeletal Pain · doi:10.1300/j094v11n02_06 · Cited by 1 · see citing works

Targeting fibromyalgia pain: brain–spinal cord and peripheral contributions

Franklyn, K., Guymer, E. K., & Littlejohn, G. O. (2011) · International Journal of Clinical Rheumatology · doi:10.2217/ijr.11.41 · Cited by 1 · see citing works

Umbilical Cord Derived Mast Cells as Models for the Study of Inflammatory Diseases

Kourelis, T., Kempuraj, D., Manola, A., & Theoharides, T. C. (2009) · Wiley eBooks · doi:10.1002/9780470480151.ch8 · Cited by 1 · see citing works

The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cellsPreprint

Sanchez, K. R., Burgess, J., Zheng, Q., Alam, U., Neiland, H., Berwick, R., Andersson, D. A., Korver, S. K., Worthington, A., Göebel, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.15.652596 · Cited by 2 · see citing works

Biological Markers of Fibromyalgia

Maes, M. H. J. (1999) · Springer eBooks · doi:10.1007/978-4-431-68500-5_11

Síndrome dolorosa disfuncional em doentes com sensibilidade exteroceptiva assimétrica: caracterização de uma entidade clínica

de Andrade, D. C. (2014)

Exploring the neuroimmune cellular landscape in the skin of subjects with fibromyalgiaPreprint

Morado-Urbina, C. E., Agashkov, K., Hunt, M. A., Tejos‐Bravo, M., af Ekenstam, K., Fanton, S., Larsson, S. V., Sándor, K., Linderoth, E., Kuliszkiewicz, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.05.686713

Evaluating skin biopsy findings in fibromyalgia: a systematic review

Bejm, N., & Gruszecka, K. (2026) · Reumatologia/Rheumatology · doi:10.5114/reum/209912

Attachment of IgG to dermal extracellular matrix in patients with fibromyalgia.

Eneström, S., Bengtson, A., Lindström, F. D., & Johan, K. (1990) · PubMed · Cited by 15 · see citing works

Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients

Blanco, I., Béritze, N., Argüelles, M., Cárcaba, V., Fernández, F., Janciauskiene, S. M., Οικονομοπούλου, Κ., de Serres, F. J., Fernández-Bustillo, E., & Hollenberg, M. D. (2010) · Clinical Rheumatology · doi:10.1007/s10067-010-1474-7 · Cited by 99 · see citing works

Exploring the neuroimmune cellular landscape in the skin of subjects with fibromyalgiaPreprint

Morado-Urbina, C. E., Agashkov, K., Hunt, M. A., Tejos‐Bravo, M., af Ekenstam, K., Fanton, S., Larsson, S. V., Sándor, K., Linderoth, E., Kuliszkiewicz, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.05.686713

Reply to: mast cells in fibromyalgia.

Cassisi, G., Ceccherelli, F., Atzeni, F., & Sarzi‐Puttini, P. (2015) · PubMed · Cited by 1 · see citing works

Immunoglobulin-G deposits at the dermal-epidermal junction in secondary (traumatic) fibromyalgia syndrome.

Cd, B. (1984) · PubMed · Cited by 6 · see citing works