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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Bennett, Gary J., Xie, Y.-K.·1988·Pain

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Abstract

A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans.

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Authors: Bennett, G. J., & Xie, Y.-K.
Affiliations: National Institutes of Health (US)
Corresponding author: Bennett, Gary J.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1988-04
Volume: 33
Issue: 1
Pages: 87-107
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/0304-3959(88)90209-6
OpenAlex: W2058020736
Cited by: 5,376
References: 34
Citations by year: 2026: 119 · 2025: 161 · 2024: 186 · 2023: 147 · 2022: 194 · 2021: 215 · 2020: 234 · 2019: 197 · 2018: 191 · 2017: 205 · 2016: 198 · 2015: 206 · 2014: 220 · 2013: 222 · 2012: 199
FWCI: 16.45
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: Fogarty International Center
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: peripheral mononeuropathy, sciatic nerve constriction, neuropathic pain, hyperalgesia, allodynia, spontaneous pain, dysesthesia, nocifensive behavior, thermal pain
MeSH terms: Animals, Behavior, Animal, Cold Temperature, Hot Temperature, Hyperalgesia, Hyperesthesia, Ligation, Male, Neurons, Afferent, Pain, Peripheral Nervous System Diseases, Rats, Inbred Strains, Reaction Time, Sciatic Nerve, Skin, Time Factors, Rats

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

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