The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Abstract
A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans.
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“CCI produces mechanical allodynia as well as thermal allodynia and hyperalgesia in the ipsilateral paw as early as two days post-surgery.37”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [37]
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Metadata
- Authors
- Bennett, G. J., & Xie, Y.-K.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Bennett, Gary J.
- Venue
- Pain
- Published
- 1988-04
- Volume
- 33
- Issue
- 1
- Pages
- 87-107
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2058020736
- Cited by
- 5,376
- References
- 34
- Citations by year
- 2026: 119 · 2025: 161 · 2024: 186 · 2023: 147 · 2022: 194 · 2021: 215 · 2020: 234 · 2019: 197 · 2018: 191 · 2017: 205 · 2016: 198 · 2015: 206 · 2014: 220 · 2013: 222 · 2012: 199
- FWCI
- 16.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fogarty International Center
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- peripheral mononeuropathy, sciatic nerve constriction, neuropathic pain, hyperalgesia, allodynia, spontaneous pain, dysesthesia, nocifensive behavior, thermal pain
- MeSH terms
- Animals, Behavior, Animal, Cold Temperature, Hot Temperature, Hyperalgesia, Hyperesthesia, Ligation, Male, Neurons, Afferent, Pain, Peripheral Nervous System Diseases, Rats, Inbred Strains, Reaction Time, Sciatic Nerve, Skin, Time Factors, Rats
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