Metabolic actions of vasopressin, glucagon and adrenalin in the intact rat

HEMS, D; WHITTON, P; MA, G

doi:10.1016/0304-4165(75)90294-9

Cited by 58Pancreatic function and diabetesMetabolism, Diabetes, and CancerRegulation of Appetite and Obesity

Metabolic actions of vasopressin, glucagon and adrenalin in the intact rat

HEMS, D, WHITTON, P, MA, G·1975·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/0304-4165(75)90294-9

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Abstract

Metabolic effects of vasopressin, glucagan and adrenalin were compared, in intact rats, especially in regard to time courses of effects. Hyperglycaemia was transient in response to vasopressin, prolonged following adrenalin, and, suprisingly, was not discernible after glucagon, except in response to a very large dose. Vasopressin decreased and adrenalin increased, the plasma free fatty acid concentration; both hormones decreased the triacylglycerol level. Muscle glycogen concentrations, measured in heart, diaphragm and skeletal muscle, exhibited small changes, with complex time courses, following hormone administration. Vasopressin brought about a rapid but transient activation of heaptic glycogen phosphorylase which resembled that due to adrenalin. The activation by glucagon of phosphorylase was greater and more prolonged, despite the absence of hyperglycaemia. In response to vasopressin, there was in increase in plasma insulin. Incorporation of 14C from [14C]glucose into glycogen or fatty acids was not influenced by vasopressin. Taken together, these results may be explained by rapid metabolic action of vasopressin on hepatic glycogenolysis, whereas adrenalin has multiple prolonged actions.

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Acute vasopressin infusion in rats and healthy individuals causes a transient rise in blood glucose.
“Acute VP infusion in the rat and in healthy individuals was shown to induce a transient rise in blood glucose concentration [4][5][6].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [4]
VP's vasoconstrictive action, which lowers hepatic blood flow, may trigger glycogen breakdown through hypoxia.
“Vasoconstrictive effects of VP and the resulting decrease in hepatic blood flow could cause hypoxia-driven glycogenolysis [4].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [4]

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Authors: HEMS, D., WHITTON, P., & MA, G.
Affiliations: Imperial College London (GB)
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 1975-11-10
Volume: 411
Issue: 1
Pages: 155-164
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/0304-4165(75)90294-9
OpenAlex: W2075365353
Cited by: 58
References: 22
Citations by year: 2022: 1 · 2021: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1
FWCI: 7.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: vasopressin, glucagon, epinephrine, hyperglycemia, plasma free fatty acids, triglycerides, muscle glycogen, glycogen phosphorylase, hepatic glycogenolysis, plasma insulin, glucose incorporation
MeSH terms: Adipose Tissue, Animals, Blood Glucose, Epinephrine, Fatty Acids, Female, Glucagon, Glycogen, Phosphorylases, Hyperglycemia, Insulin, Liver, Male, Muscles, Vasopressins, Rats

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Metabolic actions of vasopressin, glucagon and adrenalin in the intact rat

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