Stimulation by vasopressin of glycogen breakdown and gluconeogenesis in the perfused rat liver
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1. Vasopressin (anti-diuretic hormone, [8-arginine]vasopressin) stimulated the breakdown of glycogen in perfused livers of fed rats, at concentrations (50–600μunits/ml) that have been reported in the blood of intact rats, especially during acute haemorrhagic shock. 2. In perfused livers from starved rats, vasopressin (30–150μunits/ml) stimulated gluconeogenesis from a mixture of lactate, pyruvate and glycerol. 3. Vasopressin prevented accumulation of liver glycogen in the perfused liver of starved rats, or in starved intact rats. 4. The action of vasopressin on hepatic carbohydrate metabolism thus resembles that of glucagon; the minimum effective circulating concentrations of these hormones are of the same order (100pg/ml). 5. The stimulation of hepatic glucose output by vasopressin is discussed in connexion with the release of glucose and water from the liver.
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A proposed mechanism for high-VP-related glucose intolerance and insulin resistance is that intracellular glucose metabolism is impaired by enhanced gluconeogenesis and/or glycogenolysis.
“One is impaired intracellular glucose metabolism due to increased gluconeogenesis and/or increased glycogenolysis as suggested by acute experiments [31,32], an effect probably related to V1aR activation [29].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [31]
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- Authors
- Hems, D. A., & Whitton, P. D.
- Affiliations
- Imperial College London (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1973-11-15
- Volume
- 136
- Issue
- 3
- Pages
- 705-709
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1166006
- OpenAlex
- W121863172
- Cited by
- 150
- References
- 27
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- vasopressin, glycogenolysis, gluconeogenesis, hepatic carbohydrate metabolism, liver perfusion, glucagon, hepatic glucose production, starvation, hemorrhagic shock, lactate, pyruvate, glycerol
- MeSH terms
- Animals, Gluconeogenesis, Glucose, Glycerol, Lactates, Liver, Liver Glycogen, Male, Perfusion, Pyruvates, Shock, Hemorrhagic, Starvation, Vasopressins, Water, Rats
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