Repeated changes of dendritic morphology in the hippocampus of ground squirrels in the course of hibernation
Abstract
Quantitative Golgi study of hippocampal pyramidal neurons of ground squirrels showed rapid and profound transformation of their apical dendrites in the course of hibernation. The dendrites were significantly shorter, less branched and had fewer dendritic spines in the middle of hibernation bout than in the active euthermic ground squirrels between bouts. After arousal from torpor, within 2 h dendrites completely restored their structure. During hibernation, season remodelling of the hippocampal dendrites occurs repeatedly during each torpor-activity cycle.
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Changes in dendrite length and branching are not "damage," but a form of structural plasticity.
“This implies that reorganization of the cytoskeleton is taking place rapidly and reversibly, and that changes in dendrite length and branching are not “damage,” but a form of structural plasticity.”
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- Authors
- Popov, V. I., Bocharova, L. S., & Bragin, A. G.
- Affiliations
- Institute of Cell Biophysics (RU)
- Institute of Theoretical and Experimental Biophysics (RU)
- Corresponding author
- Popov, V.I.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 48
- Issue
- 1
- Pages
- 45-51
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2051157780
- Cited by
- 241
- References
- 40
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 9 · 2012: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dendritic morphology, hippocampus, ground squirrels, hibernation, torpor, dendritic spines, dendritic branching, pyramidal neurons, arousal from torpor
- MeSH terms
- Animals, Dendrites, Golgi Apparatus, Hibernation, Hippocampus, Neurons, Pyramidal Tracts, Sciuridae
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