Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons

Popov, V.I.; Bocharova, L.S.

doi:10.1016/0306-4522(92)90337-2

Cited by 203Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsPhysiological and biochemical adaptations

Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons

Popov, V.I., Bocharova, L.S.·1992·Neuroscience

DOI 10.1016/0306-4522(92)90337-2

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Abstract

Mossy fibre synapses on the CA3 hippocampal neurons in the brain of ground squirrels repeatedly undergo a striking structural transformation during hibernation. In the middle of hibernation bout the giant complex mossy fibre synapses have a reduced number of dendritic spine infoldings that are smaller and have a decreased number of postsynaptic densities in comparison with mossy fibre synapses of active animals. Two hours after arousal all these parameters of mossy fibre synapses increase and significantly exceed their levels not only in torpid but in active euthermic animals between bouts of torpor. The longer postsynaptic densities and the greater proportion of perforated postsynaptic densities were found soon after arousal. These rapid, reversible and repeated changes indicate a cyclic process of partial denervation/reinnervation of hippocampal neurons by mossy fibres in the course of the innate, stereotyped behaviour.

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Changes in the denervation/reinnervation of CA3 pyramidal neurons by mossy fibres were found during hibernation/arousal and were associated with a reversible PHF-like phosphorylation of tau over a similar time course.
“Furthermore, changes in the denervation/reinnervation of CA3 pyramidal neurons by mossy fibres were also found during hibernation/arousal (Popov and Bocharova, 1992) and they were associated with a reversible PHF-like phosphorylation of tau over a similar time course.”
From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Popov and Bocharova, 1992
Changes in dendrite length and branching are not "damage," but a form of structural plasticity.
“This implies that reorganization of the cytoskeleton is taking place rapidly and reversibly, and that changes in dendrite length and branching are not “damage,” but a form of structural plasticity.”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [60]

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Authors: Popov, V. I., & Bocharova, L. S.
Affiliations: Institute of Cell Biophysics (RU)
Institute of Theoretical and Experimental Biophysics (RU)
Corresponding author: Popov, V.I.
ORCID: Popov, V.I.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1992-05
Volume: 48
Issue: 1
Pages: 53-62
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(92)90337-2
OpenAlex: W2038852586
Cited by: 203
References: 53
Citations by year: 2026: 1 · 2025: 8 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 15 · 2018: 6 · 2017: 12 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 5 · 2012: 9
FWCI: 1.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
Keywords: hibernation, mossy fiber synapses, CA3 neurons, dendritic spines, postsynaptic density, denervation and reinnervation, arousal, ground squirrels, torpor
MeSH terms: Animals, Arousal, Endoplasmic Reticulum, Hibernation, Hippocampus, Microscopy, Electron, Microtubules, Nerve Fibers, Neurons, Pyramidal Tracts, Sciuridae, Synapses

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Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons

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