Two types of cholinergic projections to the rat amygdala
Abstract
The cholinergic innervation of the rat amygdala was studied immunohistochemically with antibodies against choline acetyltransferase and the low affinity p75 nerve growth factor receptor in normal rats and in rats lesioned with an immunotoxin, 192 IgG-saporin, directed against the p75 nerve growth factor receptor. The density of choline acetyltransferase-positive fibers was high in the nucleus of the lateral olfactory tract, the basolateral nucleus, and the amygdalohippocampal area; medium in the lateral nucleus, the cortical nucleus, the accessory basal nucleus, the periamygdaloid cortex, and the anterior amygdaloid area; and low in the medial and central nuclei. Nerve growth factor receptor-positive fibers were of medium density in the lateral nucleus, the accessory basal nucleus, the cortical nucleus, the anterior amygdaloid area, the periamygdaloid cortex, and the amygdalohippocampal area. The medial nucleus and the central nucleus displayed a low density of nerve growth factor receptor-positive fibers. The basolateral nucleus and the nucleus of the lateral olfactory tract also contained a low density of nerve growth factor receptor-positive fibers even though the two nuclei displayed the highest density of choline acetyltransferase-positive fibers in the amygdala. Injections of 192 IgG-saporin induced a complete loss of cholinergic nerve growth factor receptor-positive neurons in the basal forebrain but spared a subpopulation of nerve growth factor receptor-negative choli…
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Cholinergic innervation of the medial amygdala is not as extensive as that of other nuclei of the amygdala.
“Although cholinergic innervation of the medial amygdala is not as extensive as that of other nuclei of the amygdala [61]”
Cites
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Cholinergic projections from the basal forebrain of rat to the amygdala
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Muscarinic cholinergic influences in memory consolidation
Power, A. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00086-8 · Cited by 261 · see citing works
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Central blockade of muscarinic cholinergic receptors disrupts affective and attentional set‐shifting
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- Authors
- Heckers, S., & Mesulam, M.-M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Heckers, S.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1994-05
- Volume
- 60
- Issue
- 2
- Pages
- 383-397
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2093811993
- Cited by
- 105
- References
- 3
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns020285-15)
- National Institute of Neurological Disorders and Stroke (NS 20285)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- cholinergic projections, amygdala, choline acetyltransferase, p75 nerve growth factor receptor, 192 IgG-saporin, cholinergic neurons, basolateral amygdala, stria terminalis, acetylcholinesterase, rats
- MeSH terms
- Saporins, Amygdala, Animals, Immunotoxins, Brain, Choline O-Acetyltransferase, Immunoglobulin G, Immunohistochemistry, Male, Nerve Fibers, Neurons, N-Glycosyl Hydrolases, Plant Proteins, Gene Expression, Rats, Sprague-Dawley, Receptors, Nerve Growth Factor, Rats, Ribosome Inactivating Proteins, Type 1
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