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Cited by 470Sleep and Wakefulness ResearchSleep and related disordersSleep and Work-Related Fatigue

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

A model of human sleep homeostasis based on EEG slow-wave activity: Quantitative comparison of data and simulations

Achermann, Peter, Dijk, Derk-Jan, Brunner, Daniel P., Borbély, Alexander A.·1993·Brain Research Bulletin
DOI 10.1016/0361-9230(93)90016-5
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Abstract

EEG slow-wave activity (SWA; spectral power in the 0.75-4.5 Hz band) is a function of the duration of prior waking and, thereby, an indicator of sleep homeostasis. We present a model that accounts for both the declining trend of SWA during sleep and for its variation within the successive nonrapid eye movement (non-REM) sleep episodes. The values of the model parameters were estimated by an optimization procedure in which empirical SWA of baseline nights (16 subjects, 26 nights) served as a reference. A sensitivity analysis revealed the model to be quite robust to small changes (+/- 5%) of the parameter values. The estimated parameter values were used to simulate data sets from three different experimental protocols (sleep in the evening or sleep in the morning after prolonged waking, or extended sleep initiated at the habitual bedtime; n = 8 or 9). The timing of the REM trigger parameter was derived from the empirical data. A close fit was obtained between the simulated and empirical SWA data, and even the occasional late SWA peaks during extended sleep could be reproduced. Minor discrepancies suggest indirect or direct circadian influences on SWA. The simulations demonstrate that the concept of sleep homeostasis as proposed in the two-process model of sleep regulation can be refined to account in quantitative terms for empirical data and to predict the changes induced by the prolongation of waking or sleep.

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Crossref · 10.1016/0361-9230(93)90016-5

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Research works printed but not linked: 1

  1. Beersma, 1987, Sleep intensity and timing: A model for their circadian control, vol. 19, 39

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Metadata

Authors
Achermann, P., Dijk, D.-J., Brunner, D. P., & Borbély, A. A.
Affiliations
University of Zurich (CH)
Corresponding author
Achermann, Peter
ORCID
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
1993
Volume
31
Issue
1-2
Pages
97-113
ISSN
0361-9230 (ISSN-L)
DOI
10.1016/0361-9230(93)90016-5
OpenAlex
W1963859198
Cited by
470
References
59
Citations by year
2026: 12 · 2025: 15 · 2024: 22 · 2023: 18 · 2022: 23 · 2021: 12 · 2020: 15 · 2019: 21 · 2018: 24 · 2017: 16 · 2016: 15 · 2015: 20 · 2014: 15 · 2013: 25 · 2012: 14
FWCI
4.43
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research Bulletin (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders
National Institutes of Health (RRO1693)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
sleep homeostasis, EEG slow-wave activity, NREM sleep, REM sleep, sleep-wake cycle, parameter estimation
MeSH terms
Adult, Circadian Rhythm, Computer Simulation, Electroencephalography, Homeostasis, Humans, Male, Models, Biological, Sleep, Sleep Deprivation, Sleep Stages

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